| Definition | Burkholderia glumae BGR1 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_012724 |
| Length | 3,906,507 |
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The map label for this gene is dkgB [H]
Identifier: 238027381
GI number: 238027381
Start: 1949834
End: 1950667
Strand: Reverse
Name: dkgB [H]
Synonym: bglu_1g17770
Alternate gene names: 238027381
Gene position: 1950667-1949834 (Counterclockwise)
Preceding gene: 238027382
Following gene: 238027380
Centisome position: 49.93
GC content: 58.87
Gene sequence:
>834_bases ATGCAAAGCGTCGTGATTGACTCTCACCAAATGAACATGCCTAAGCTGGGCTTGGGAACGTGGCCGATGGTGGGCGAGGA ATGCACGCGGGCCGTTGCGCTGGCTCTGGAACTCGGCTATCGGCACGTCGATACCGCAGCGGCCTACAACAACGAGGAAG CAGTCGGTCGTGCGCTGGCCGAATCCAGTGTGTCGCGCGATGATATTTATCTGACCAGCAAGGTGTGGTGGGACAAACTA TCCCCGGCGGATATGCAGCAATCGCTCGACAACTCGCGGCGGTCGTTGCGGACCGACTATTTGGATTTGTTCCTGATCCA TTGGCCGAGCAAGGACTGGGATCTCGAACGCACGATCGACACGCTGATTTCGTTTAAGGAACGTGGGTACGCCCGTAACA TAGGGGTGGCGAACTTCCCGTTGCCCTTGCTCCGCCAAGTGGTGGTGGAGATGGGCGCCCCGATCGCTGCGCATCAAGTG GAATACCATGTCACGCTTGGCCAGAGCAAGCTGCTGCAGTTCGCGATCGAGCATGATATTGCGCTGGTTGCCTATAGTCC GCTGGCGCGCAACCGGGCGGCCGAGATCCCGGAGATTCGTCGTATCGCAGAGAAGCACGGCGTGCTTCCGACTCAGGTGG CGCTCAAATGGCTGCTCGACCAGCCGAATGTCGCTGCCATTCCCAAGGCTGCCAGCCGTGTCAATCAGTCGAGCAATCTC GAATCCTTCAAGGTCCAGCTTGACGACGAGGACCGCGCGCTCATTGCTGCCCTTCCAAAAAATCAACGAGTGGTGAGCCC GGAATTCGCCCCCCAATGGGATCCGGCCGAATGA
Upstream 100 bases:
>100_bases ACTACCGGCGAGGGTGTCGGAGCACGGCGCACCGCCGCCGCCCCTTTCCGAGCGCCGCCAATTGGCAATATTGATATTTG AACAGCAAGGAAAAACCGAA
Downstream 100 bases:
>100_bases CGGCGCCGCAACAGGCGGCTTTCGAAGAAGGGGAGCAAGCCGCGCCGACAGCATGATTTTCGAAAGTGTCGTCGGCAGAC GAGGCAGGCGGCGATTTTCA
Product: aldo/keto reductase
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 277; Mature: 277
Protein sequence:
>277_residues MQSVVIDSHQMNMPKLGLGTWPMVGEECTRAVALALELGYRHVDTAAAYNNEEAVGRALAESSVSRDDIYLTSKVWWDKL SPADMQQSLDNSRRSLRTDYLDLFLIHWPSKDWDLERTIDTLISFKERGYARNIGVANFPLPLLRQVVVEMGAPIAAHQV EYHVTLGQSKLLQFAIEHDIALVAYSPLARNRAAEIPEIRRIAEKHGVLPTQVALKWLLDQPNVAAIPKAASRVNQSSNL ESFKVQLDDEDRALIAALPKNQRVVSPEFAPQWDPAE
Sequences:
>Translated_277_residues MQSVVIDSHQMNMPKLGLGTWPMVGEECTRAVALALELGYRHVDTAAAYNNEEAVGRALAESSVSRDDIYLTSKVWWDKL SPADMQQSLDNSRRSLRTDYLDLFLIHWPSKDWDLERTIDTLISFKERGYARNIGVANFPLPLLRQVVVEMGAPIAAHQV EYHVTLGQSKLLQFAIEHDIALVAYSPLARNRAAEIPEIRRIAEKHGVLPTQVALKWLLDQPNVAAIPKAASRVNQSSNL ESFKVQLDDEDRALIAALPKNQRVVSPEFAPQWDPAE >Mature_277_residues MQSVVIDSHQMNMPKLGLGTWPMVGEECTRAVALALELGYRHVDTAAAYNNEEAVGRALAESSVSRDDIYLTSKVWWDKL SPADMQQSLDNSRRSLRTDYLDLFLIHWPSKDWDLERTIDTLISFKERGYARNIGVANFPLPLLRQVVVEMGAPIAAHQV EYHVTLGQSKLLQFAIEHDIALVAYSPLARNRAAEIPEIRRIAEKHGVLPTQVALKWLLDQPNVAAIPKAASRVNQSSNL ESFKVQLDDEDRALIAALPKNQRVVSPEFAPQWDPAE
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=35.3535353535354, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=35.2727272727273, Blast_Score=147, Evalue=8e-36, Organism=Homo sapiens, GI310109920, Length=294, Percent_Identity=34.3537414965986, Blast_Score=143, Evalue=2e-34, Organism=Homo sapiens, GI45446745, Length=294, Percent_Identity=34.3537414965986, Blast_Score=142, Evalue=2e-34, Organism=Homo sapiens, GI4503285, Length=294, Percent_Identity=34.3537414965986, Blast_Score=142, Evalue=2e-34, Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=34.0136054421769, Blast_Score=140, Evalue=8e-34, Organism=Homo sapiens, GI24497577, Length=299, Percent_Identity=31.1036789297659, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI5174391, Length=299, Percent_Identity=31.1036789297659, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI24497583, Length=289, Percent_Identity=34.2560553633218, Blast_Score=133, Evalue=2e-31, Organism=Homo sapiens, GI223468663, Length=303, Percent_Identity=30.3630363036304, Blast_Score=132, Evalue=4e-31, Organism=Homo sapiens, GI93277124, Length=301, Percent_Identity=27.2425249169435, Blast_Score=124, Evalue=1e-28, Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=29.6296296296296, Blast_Score=120, Evalue=1e-27, Organism=Homo sapiens, GI291291012, Length=269, Percent_Identity=29.7397769516729, Blast_Score=114, Evalue=8e-26, Organism=Homo sapiens, GI4502049, Length=301, Percent_Identity=29.2358803986711, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=29.7101449275362, Blast_Score=108, Evalue=5e-24, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=28.9377289377289, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI207028673, Length=104, Percent_Identity=43.2692307692308, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI310109926, Length=104, Percent_Identity=43.2692307692308, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=32.9032258064516, Blast_Score=69, Evalue=6e-12, Organism=Escherichia coli, GI1786400, Length=268, Percent_Identity=42.5373134328358, Blast_Score=208, Evalue=3e-55, Organism=Escherichia coli, GI87082198, Length=255, Percent_Identity=34.9019607843137, Blast_Score=162, Evalue=2e-41, Organism=Escherichia coli, GI1788081, Length=277, Percent_Identity=31.4079422382672, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI87081735, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=8e-16, Organism=Escherichia coli, GI1787674, Length=270, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=3e-15, Organism=Escherichia coli, GI1789375, Length=296, Percent_Identity=25, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1788070, Length=322, Percent_Identity=22.6708074534161, Blast_Score=64, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17537077, Length=299, Percent_Identity=32.1070234113712, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17552492, Length=282, Percent_Identity=30.1418439716312, Blast_Score=127, Evalue=4e-30, Organism=Caenorhabditis elegans, GI17537075, Length=301, Percent_Identity=30.5647840531561, Blast_Score=127, Evalue=4e-30, Organism=Caenorhabditis elegans, GI17561298, Length=271, Percent_Identity=31.3653136531365, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17566692, Length=282, Percent_Identity=28.7234042553192, Blast_Score=124, Evalue=4e-29, Organism=Caenorhabditis elegans, GI17550248, Length=294, Percent_Identity=28.2312925170068, Blast_Score=123, Evalue=1e-28, Organism=Caenorhabditis elegans, GI71998625, Length=276, Percent_Identity=29.3478260869565, Blast_Score=118, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17561300, Length=275, Percent_Identity=31.2727272727273, Blast_Score=116, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=28.0645161290323, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17537079, Length=296, Percent_Identity=29.7297297297297, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17538386, Length=264, Percent_Identity=28.7878787878788, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562292, Length=282, Percent_Identity=27.3049645390071, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17550246, Length=72, Percent_Identity=44.4444444444444, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324694, Length=291, Percent_Identity=31.2714776632302, Blast_Score=145, Evalue=1e-35, Organism=Saccharomyces cerevisiae, GI6320576, Length=289, Percent_Identity=31.4878892733564, Blast_Score=139, Evalue=7e-34, Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=29.746835443038, Blast_Score=125, Evalue=8e-30, Organism=Saccharomyces cerevisiae, GI6319625, Length=284, Percent_Identity=32.7464788732394, Blast_Score=120, Evalue=2e-28, Organism=Saccharomyces cerevisiae, GI6320079, Length=245, Percent_Identity=28.9795918367347, Blast_Score=84, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6322556, Length=263, Percent_Identity=24.7148288973384, Blast_Score=84, Evalue=3e-17, Organism=Drosophila melanogaster, GI24644950, Length=298, Percent_Identity=31.5436241610738, Blast_Score=152, Evalue=2e-37, Organism=Drosophila melanogaster, GI221378297, Length=318, Percent_Identity=29.559748427673, Blast_Score=144, Evalue=4e-35, Organism=Drosophila melanogaster, GI21356425, Length=282, Percent_Identity=29.4326241134752, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI45553081, Length=283, Percent_Identity=31.095406360424, Blast_Score=139, Evalue=3e-33, Organism=Drosophila melanogaster, GI24657054, Length=281, Percent_Identity=28.8256227758007, Blast_Score=132, Evalue=3e-31, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=31.2280701754386, Blast_Score=128, Evalue=5e-30, Organism=Drosophila melanogaster, GI20129731, Length=280, Percent_Identity=30, Blast_Score=124, Evalue=5e-29, Organism=Drosophila melanogaster, GI24662789, Length=280, Percent_Identity=30.3571428571429, Blast_Score=118, Evalue=4e-27, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=29.0697674418605, Blast_Score=114, Evalue=8e-26, Organism=Drosophila melanogaster, GI24662781, Length=286, Percent_Identity=33.2167832167832, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=32.5423728813559, Blast_Score=110, Evalue=7e-25,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31100; Mature: 31100
Theoretical pI: Translated: 5.63; Mature: 5.63
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQSVVIDSHQMNMPKLGLGTWPMVGEECTRAVALALELGYRHVDTAAAYNNEEAVGRALA CCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHH ESSVSRDDIYLTSKVWWDKLSPADMQQSLDNSRRSLRTDYLDLFLIHWPSKDWDLERTID HHCCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHH TLISFKERGYARNIGVANFPLPLLRQVVVEMGAPIAAHQVEYHVTLGQSKLLQFAIEHDI HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHEEEEEEEEECHHHHHHHHHHCCE ALVAYSPLARNRAAEIPEIRRIAEKHGVLPTQVALKWLLDQPNVAAIPKAASRVNQSSNL EEEEECCHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC ESFKVQLDDEDRALIAALPKNQRVVSPEFAPQWDPAE CEEEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCC >Mature Secondary Structure MQSVVIDSHQMNMPKLGLGTWPMVGEECTRAVALALELGYRHVDTAAAYNNEEAVGRALA CCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHH ESSVSRDDIYLTSKVWWDKLSPADMQQSLDNSRRSLRTDYLDLFLIHWPSKDWDLERTID HHCCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHH TLISFKERGYARNIGVANFPLPLLRQVVVEMGAPIAAHQVEYHVTLGQSKLLQFAIEHDI HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHEEEEEEEEECHHHHHHHHHHCCE ALVAYSPLARNRAAEIPEIRRIAEKHGVLPTQVALKWLLDQPNVAAIPKAASRVNQSSNL EEEEECCHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC ESFKVQLDDEDRALIAALPKNQRVVSPEFAPQWDPAE CEEEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796; 11108008 [H]