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The map label for this gene is ghrB [H]

Identifier: 238027239

GI number: 238027239

Start: 1782823

End: 1783791

Strand: Direct

Name: ghrB [H]

Synonym: bglu_1g16250

Alternate gene names: 238027239

Gene position: 1782823-1783791 (Clockwise)

Preceding gene: 238027238

Following gene: 238027240

Centisome position: 45.64

GC content: 71.21

Gene sequence:

>969_bases
ATGACTTATCGTATCGTTGCGTACAAGACGCTGCCCGATGAGGTGCTTGCCTATCTGCGCGAGCACGCCGAGGTGATCCA
GGCCGACGGCGCCGCGGCGCTGACCGAGGCGCTTGCCGGGGCCGACGGCGCGATCGGCGCGAGCGTGCCGGTCACCGCCG
AGATGCTCGATCGTGCGCCGAAGCTGCGCGCATGGTCGACCATCTCGGTCGGCTACGACCAGTTCGACGTCGCCGACCTG
ACGCGGCGCGGCATCGTGCTCGCCCACACCCCCGACGTGCTGACCGAATCGACCGCCGATACGGTGTTCGCGCTGATGCT
CGCCAGCGCGCGCCGCGTGGTGGAGCTGGCCGAGTTCGTCAAGGCGGGCGAGTGGAAAGAGAGCATCGGCGAGCGGTACT
ACGGCACCGACGTCCAGGGCAAGACGCTCGGCATCGTCGGGCTCGGCCGGATCGGCGCGGCGGTGGCGCGGCGCGCGGCG
CTCGGCTTCCGGATGCGCGTGCTGTACACCAACCGCCACCCCAACGAGCAGGCCGAGGCGCAGTTCGGCGCGCGCCGCGT
GCCGCTCGACGAACTGCTCGCCACCGCCGATTTCGTCTGCCTGCAGGTGCCGCTGACCGAGGCGACGCGGCACCTGATCG
GCGCGCCCCAGTTCGCGAGGATGAAGCGCAGCGCGATCCTGATCAATGCCGCGCGCGGGCCGGTGGTGGACGAAGCCGCG
CTGATCGAGGCACTGCGCGCCGGCACGATTCGCGGCGCCGGCCTCGACGTGTTCGAGCAGGAGCCGCTGGCGGCCGATTC
GCCGCTGCTCGCGATGAAGAACGTGGTGGCGCTGCCGCACATCGGCTCGGCGACGGGCGAGACGCGCCGCGCGATGGCGC
GCAACGCGGCCGAGAACCTGATCGGCGCGCTCGACGGCACGCTGCGCGAGAACATCGTCAATCGCGACGTGCTGAACGGG
CGCCGCTGA

Upstream 100 bases:

>100_bases
TGAGCGCGGCGCTGGTGGCCTCGGTGGTGCTGACGCTGATCGTCAGGCCCCAGCCGGACGCGCCGCCGCTCGCACACTCC
ACCACCGGGAAATGAATCGC

Downstream 100 bases:

>100_bases
GGCCGGCCGCTTGCGGACGCAAGCGTGCGGACGATCCCCGGCCGCGCCGCCACGCCGGTCACCGCGCGCCGTCGAGCGCC
GGGCCTGGCGACGCAGCCGG

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTYRIVAYKTLPDEVLAYLREHAEVIQADGAAALTEALAGADGAIGASVPVTAEMLDRAPKLRAWSTISVGYDQFDVADL
TRRGIVLAHTPDVLTESTADTVFALMLASARRVVELAEFVKAGEWKESIGERYYGTDVQGKTLGIVGLGRIGAAVARRAA
LGFRMRVLYTNRHPNEQAEAQFGARRVPLDELLATADFVCLQVPLTEATRHLIGAPQFARMKRSAILINAARGPVVDEAA
LIEALRAGTIRGAGLDVFEQEPLAADSPLLAMKNVVALPHIGSATGETRRAMARNAAENLIGALDGTLRENIVNRDVLNG
RR

Sequences:

>Translated_322_residues
MTYRIVAYKTLPDEVLAYLREHAEVIQADGAAALTEALAGADGAIGASVPVTAEMLDRAPKLRAWSTISVGYDQFDVADL
TRRGIVLAHTPDVLTESTADTVFALMLASARRVVELAEFVKAGEWKESIGERYYGTDVQGKTLGIVGLGRIGAAVARRAA
LGFRMRVLYTNRHPNEQAEAQFGARRVPLDELLATADFVCLQVPLTEATRHLIGAPQFARMKRSAILINAARGPVVDEAA
LIEALRAGTIRGAGLDVFEQEPLAADSPLLAMKNVVALPHIGSATGETRRAMARNAAENLIGALDGTLRENIVNRDVLNG
RR
>Mature_321_residues
TYRIVAYKTLPDEVLAYLREHAEVIQADGAAALTEALAGADGAIGASVPVTAEMLDRAPKLRAWSTISVGYDQFDVADLT
RRGIVLAHTPDVLTESTADTVFALMLASARRVVELAEFVKAGEWKESIGERYYGTDVQGKTLGIVGLGRIGAAVARRAAL
GFRMRVLYTNRHPNEQAEAQFGARRVPLDELLATADFVCLQVPLTEATRHLIGAPQFARMKRSAILINAARGPVVDEAAL
IEALRAGTIRGAGLDVFEQEPLAADSPLLAMKNVVALPHIGSATGETRRAMARNAAENLIGALDGTLRENIVNRDVLNGR
R

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=291, Percent_Identity=42.2680412371134, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=33.5820895522388, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI61743967, Length=290, Percent_Identity=36.2068965517241, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=290, Percent_Identity=36.2068965517241, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580578, Length=290, Percent_Identity=35.8620689655172, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI4557499, Length=290, Percent_Identity=35.8620689655172, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI145580575, Length=290, Percent_Identity=35.8620689655172, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=58.3850931677019, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=32.9501915708812, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787645, Length=248, Percent_Identity=28.2258064516129, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=32.6388888888889, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=320, Percent_Identity=33.125, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=301, Percent_Identity=27.5747508305648, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=41.2017167381974, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=256, Percent_Identity=35.9375, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=256, Percent_Identity=34.765625, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325144, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=241, Percent_Identity=29.045643153527, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=162, Percent_Identity=30.8641975308642, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=154, Percent_Identity=31.1688311688312, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552429, Length=310, Percent_Identity=40.3225806451613, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI45551003, Length=310, Percent_Identity=40.3225806451613, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24585514, Length=310, Percent_Identity=40.3225806451613, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI28574282, Length=310, Percent_Identity=40.3225806451613, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI28574284, Length=310, Percent_Identity=40.3225806451613, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI28574286, Length=311, Percent_Identity=37.620578778135, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI28571528, Length=277, Percent_Identity=42.9602888086643, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24585516, Length=309, Percent_Identity=33.9805825242718, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19921140, Length=294, Percent_Identity=32.6530612244898, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646446, Length=291, Percent_Identity=35.3951890034364, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=291, Percent_Identity=35.3951890034364, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=291, Percent_Identity=35.3951890034364, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=291, Percent_Identity=35.3951890034364, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472511, Length=291, Percent_Identity=35.3951890034364, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34590; Mature: 34459

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRIVAYKTLPDEVLAYLREHAEVIQADGAAALTEALAGADGAIGASVPVTAEMLDRAP
CCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC
KLRAWSTISVGYDQFDVADLTRRGIVLAHTPDVLTESTADTVFALMLASARRVVELAEFV
CCCCCEEEECCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGEWKESIGERYYGTDVQGKTLGIVGLGRIGAAVARRAALGFRMRVLYTNRHPNEQAEA
HCCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHH
QFGARRVPLDELLATADFVCLQVPLTEATRHLIGAPQFARMKRSAILINAARGPVVDEAA
HHCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHCCCHHHHHHHCEEEEECCCCCCCHHHH
LIEALRAGTIRGAGLDVFEQEPLAADSPLLAMKNVVALPHIGSATGETRRAMARNAAENL
HHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
IGALDGTLRENIVNRDVLNGRR
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TYRIVAYKTLPDEVLAYLREHAEVIQADGAAALTEALAGADGAIGASVPVTAEMLDRAP
CEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC
KLRAWSTISVGYDQFDVADLTRRGIVLAHTPDVLTESTADTVFALMLASARRVVELAEFV
CCCCCEEEECCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGEWKESIGERYYGTDVQGKTLGIVGLGRIGAAVARRAALGFRMRVLYTNRHPNEQAEA
HCCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHH
QFGARRVPLDELLATADFVCLQVPLTEATRHLIGAPQFARMKRSAILINAARGPVVDEAA
HHCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHCCCHHHHHHHCEEEEECCCCCCCHHHH
LIEALRAGTIRGAGLDVFEQEPLAADSPLLAMKNVVALPHIGSATGETRRAMARNAAENL
HHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
IGALDGTLRENIVNRDVLNGRR
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA