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The map label for this gene is qor [C]

Identifier: 238027212

GI number: 238027212

Start: 1748132

End: 1749148

Strand: Direct

Name: qor [C]

Synonym: bglu_1g15980

Alternate gene names: 238027212

Gene position: 1748132-1749148 (Clockwise)

Preceding gene: 238027209

Following gene: 238027213

Centisome position: 44.75

GC content: 70.5

Gene sequence:

>1017_bases
ATGAAAGCCGTAGGTCTGACCCGCTACCTGCCGATCGACCATCCCGAGGCGCTGCTCGACGTCGAGTTGCCGACGCCCGA
GCCCGCAGGACGCGACCTGCTCGTCAAGATCGAGGCGATTTCGGTCAACCCGGTCGACACCAAGGTGCGCGCGCCGCAGG
ACAAGGTCGAGGACAGCCCGCGCGTGCTGGGCTGGGACGCGGCCGGCACGGTGGCCGCCGTCGGCCCGGACGTGACGCTG
TTTCGCGTCGGCGATCCGGTCTACTACGCCGGCAGCATCACGCGCGCCGGCGCCAACAGCGAGTTCCATCTGGTGGACGA
GCGGATCGCGGCGCTCAAGCCCGCGTCGCTCGATTTCGCCGCGGCGGCGGCGCTGCCGCTCACGTCGATCACCGCCTGGG
AGGCGCTGTTCGACCGCCTCAAGGTGTCGCCGCAGGGGCGCGACGCGGGCCAGTCGGTGCTCGTGATCGGCGGCGCGGGC
GGGGTCGGCTCGATCGGCATCCAGCTCGCGAAGCAACTCGGACAGCTGACGGTGATCGCCACGGCGTCGCGGCCGGAATC
GGCGCAATGGGTGCGCCGGCTCGGCGCCGACCAGGTGGTCGATCACTTCGGCGATCTGCCCGCGCAGGTCCGCGCCGCCG
GCTTCGAGGCGGTCGACTACGTGCTGGTGTTCAACGACACCGACCGTCATTTCCCGGCCGCGGCCGAGCTCGTCAAGCCG
CAGGGCGGGATCTGCACCATCGTCGAGAATGCGCGGCCGGTGCCCGTCGAGCAGCTGAAGGCAAAGAGCGCCGCATTCCA
CTGGGAGTTCATGTTCACGCGCTCGATGTTCGGCACGCCGGACATGATCGAGCAGCACAAGCTGCTGACCGAGGTCGCGC
GGCTGGTGGACGCCGGCACGCTGCGCGGCACGGTGGGCCAGCACCTCGGCACGATCAACGCGGCCAACCTGCGCGAGGCG
CACCGCCTGCTCGAAGCCGGCCGCGCGATCGGCAAGCTCGTGCTGAGCGGGTTCTGA

Upstream 100 bases:

>100_bases
CCAAAAAATGTTTCCGGGATTATGTCGCTTTTTCTTCAGGATCGGGCCGCTTACGATCGGACCCGTCACCAACCCCGATT
GCCCCCGAAGGAGCCAAGCC

Downstream 100 bases:

>100_bases
CGCGCCGCATGGGGCCGGTGCCGATGAGGGCGCGATTGCCTGCCGGAGCCGGGCCGGCAGGCAATCGGCACGGCCGGCAA
CCACGGCTGCCGCGGGCCAG

Product: NADPH:quinone reductase and related Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVGLTRYLPIDHPEALLDVELPTPEPAGRDLLVKIEAISVNPVDTKVRAPQDKVEDSPRVLGWDAAGTVAAVGPDVTL
FRVGDPVYYAGSITRAGANSEFHLVDERIAALKPASLDFAAAAALPLTSITAWEALFDRLKVSPQGRDAGQSVLVIGGAG
GVGSIGIQLAKQLGQLTVIATASRPESAQWVRRLGADQVVDHFGDLPAQVRAAGFEAVDYVLVFNDTDRHFPAAAELVKP
QGGICTIVENARPVPVEQLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDAGTLRGTVGQHLGTINAANLREA
HRLLEAGRAIGKLVLSGF

Sequences:

>Translated_338_residues
MKAVGLTRYLPIDHPEALLDVELPTPEPAGRDLLVKIEAISVNPVDTKVRAPQDKVEDSPRVLGWDAAGTVAAVGPDVTL
FRVGDPVYYAGSITRAGANSEFHLVDERIAALKPASLDFAAAAALPLTSITAWEALFDRLKVSPQGRDAGQSVLVIGGAG
GVGSIGIQLAKQLGQLTVIATASRPESAQWVRRLGADQVVDHFGDLPAQVRAAGFEAVDYVLVFNDTDRHFPAAAELVKP
QGGICTIVENARPVPVEQLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDAGTLRGTVGQHLGTINAANLREA
HRLLEAGRAIGKLVLSGF
>Mature_338_residues
MKAVGLTRYLPIDHPEALLDVELPTPEPAGRDLLVKIEAISVNPVDTKVRAPQDKVEDSPRVLGWDAAGTVAAVGPDVTL
FRVGDPVYYAGSITRAGANSEFHLVDERIAALKPASLDFAAAAALPLTSITAWEALFDRLKVSPQGRDAGQSVLVIGGAG
GVGSIGIQLAKQLGQLTVIATASRPESAQWVRRLGADQVVDHFGDLPAQVRAAGFEAVDYVLVFNDTDRHFPAAAELVKP
QGGICTIVENARPVPVEQLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDAGTLRGTVGQHLGTINAANLREA
HRLLEAGRAIGKLVLSGF

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=339, Percent_Identity=28.9085545722714, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194239674, Length=204, Percent_Identity=33.8235294117647, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI13236495, Length=204, Percent_Identity=33.8235294117647, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI194239676, Length=204, Percent_Identity=33.8235294117647, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI24308257, Length=327, Percent_Identity=25.9938837920489, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI18379349, Length=247, Percent_Identity=29.9595141700405, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790485, Length=188, Percent_Identity=35.1063829787234, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=182, Percent_Identity=34.6153846153846, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=189, Percent_Identity=34.3915343915344, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319945, Length=238, Percent_Identity=28.9915966386555, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324195, Length=227, Percent_Identity=27.7533039647577, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36026; Mature: 36026

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGLTRYLPIDHPEALLDVELPTPEPAGRDLLVKIEAISVNPVDTKVRAPQDKVEDSP
CCCCCCEEECCCCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCCC
RVLGWDAAGTVAAVGPDVTLFRVGDPVYYAGSITRAGANSEFHLVDERIAALKPASLDFA
CEEEECCCCCEEECCCCEEEEEECCCEEEECCEEECCCCCCEEEHHHHHHHCCCCCCCHH
AAAALPLTSITAWEALFDRLKVSPQGRDAGQSVLVIGGAGGVGSIGIQLAKQLGQLTVIA
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
TASRPESAQWVRRLGADQVVDHFGDLPAQVRAAGFEAVDYVLVFNDTDRHFPAAAELVKP
ECCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCC
QGGICTIVENARPVPVEQLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDAGT
CCCEEEEECCCCCCCHHHHHHHHHEEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCC
LRGTVGQHLGTINAANLREAHRLLEAGRAIGKLVLSGF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAVGLTRYLPIDHPEALLDVELPTPEPAGRDLLVKIEAISVNPVDTKVRAPQDKVEDSP
CCCCCCEEECCCCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHCCCCC
RVLGWDAAGTVAAVGPDVTLFRVGDPVYYAGSITRAGANSEFHLVDERIAALKPASLDFA
CEEEECCCCCEEECCCCEEEEEECCCEEEECCEEECCCCCCEEEHHHHHHHCCCCCCCHH
AAAALPLTSITAWEALFDRLKVSPQGRDAGQSVLVIGGAGGVGSIGIQLAKQLGQLTVIA
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
TASRPESAQWVRRLGADQVVDHFGDLPAQVRAAGFEAVDYVLVFNDTDRHFPAAAELVKP
ECCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCC
QGGICTIVENARPVPVEQLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDAGT
CCCEEEEECCCCCCCHHHHHHHHHEEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCC
LRGTVGQHLGTINAANLREAHRLLEAGRAIGKLVLSGF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]