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The map label for this gene is fumC [H]

Identifier: 238026578

GI number: 238026578

Start: 998871

End: 1000265

Strand: Reverse

Name: fumC [H]

Synonym: bglu_1g09220

Alternate gene names: 238026578

Gene position: 1000265-998871 (Counterclockwise)

Preceding gene: 238026579

Following gene: 238026575

Centisome position: 25.61

GC content: 67.74

Gene sequence:

>1395_bases
ATGAGCGAAGCAGTACGGATGGAACGCGACACGTTCGGCGAAATCGCGGTGCCGGACGCCCGCCTGTGGGGTGCCCAGAC
GCAGCGTTCGCTGCAGAACTTCCGGATCTCAACGGAAAAGCAGTCGCCCGAGCTGATCCATGCGCTCGCGCTGATCAAGC
GCGCGGCGGCCAGCGTCAACCGTGAGCTCGGCGTGCTGCCGGAGGACAAGGCGAACGCGATCGTGGCGGCAGCCGACGAA
ATCATCGCCGGCAGGCACCCGGACGAGTTCCCGCTCGCGGTCTGGCAGACCGGCTCGGGCACGCAAACCAACATGAACCT
CAACGAGGTGATCGCGAACCGCGCGAGCGAGCTGCTGGGCGGGGTGCGCGGCGAGTCGCGCAAGGTCCACCCGAACGACG
ACGTGAACCGCGGCCAGTCGTCGAACGACGTGTTCCCGACGGCGATGCACATCGCCGCCGCGCTCGCGATCCACGCCCGG
CTGCTGCCGGCGTTGAAGCGCCTGCGCGCGACGCTCGACGAGAAGTCGAAGGCGTTCGCCGCGATCGTCAAGATCGGCCG
CACGCACCTGCAGGACGCCACGCCGCTCACGCTCGGCCAGGAGTTCTCGGGCTACGTGGCGCAGCTCGACCAGGGCATCC
GCCACGTCGAATCGACGCTGCCGCATCTGTACGAACTCGCGCAGGGCGGCACCGCGGTCGGCACCGGCCTCAACGCACAT
CCGCAGTTCGCGGCGGCGGTGGCCGACGAAATCGGCCGGCTCACCCAGTTGCCGTTCGTCACGGCACCAAACAAGTTCGA
GGTCATGGCCGCGGCCGACGCGCTGGTGTTCGCGCACGGCGCGCTGAAGACGGTCGCCGCGAGCCTGATGAAGATCGCCA
ACGACGTGCGCTGGCTCGCCAGCGGCCCGCGCTGCGGTCTCGGCGAGCTGTCGATCCCGGAAAACGAGCCGGGCAGCTCG
ATCATGCCGGGCAAGGTGAACCCGACCCAGTCCGAGGCGGTGACGATGCTGTGCTGCCAGGTGTTCGGCAACGACGTGGC
GGTGAATTTCGGCGGCGCGAGCGGCAACTTCGAGTTGAACGTGTTCCGTCCGATGATCGCGCACAACGTGCTGCAGTCGG
TGCGGCTGCTGGCCGACGGCGCGCTCAGCTTCAACGACCACTGCGCGGTCGGCATCGAGCCGAACCGTTCACGCATCGAC
ACGCTGCTCAATGAATCGCTGATGCTGGTGACGGCGCTCAATCCGCACATCGGCTACGACAAGGCCGCCCAGATCGCGAA
GAAGGCGCACAAGGACGGCACCACGCTGAAGGCCGCCGCGCTCGCGCTCGGCTACGTGAGCGAGGCGCAATTCGACGAGT
GGGTCAAGCCGGCCGAGATGATCGGCAAGCCCTGA

Upstream 100 bases:

>100_bases
GCCTCCGGACGCCGTCGCCAGAACGGTGCCCGTCCCCACTTGCGCTTTCATGCCGTGCGCCGCGCGGCATGGTCCCTTTC
TCAGTGACGGAGTCATCAAG

Downstream 100 bases:

>100_bases
GCGGCACGGCCGGCGCCGCCGCGATGCCCGGCAGGCCCGGGCGGTGGGGCGGACGCGCCGGCCGGCATCACTGCCGGGTC
CGGGCTCGCGCATCGTCCGT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSEAVRMERDTFGEIAVPDARLWGAQTQRSLQNFRISTEKQSPELIHALALIKRAAASVNRELGVLPEDKANAIVAAADE
IIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGVRGESRKVHPNDDVNRGQSSNDVFPTAMHIAAALAIHAR
LLPALKRLRATLDEKSKAFAAIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESTLPHLYELAQGGTAVGTGLNAH
PQFAAAVADEIGRLTQLPFVTAPNKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGALSFNDHCAVGIEPNRSRID
TLLNESLMLVTALNPHIGYDKAAQIAKKAHKDGTTLKAAALALGYVSEAQFDEWVKPAEMIGKP

Sequences:

>Translated_464_residues
MSEAVRMERDTFGEIAVPDARLWGAQTQRSLQNFRISTEKQSPELIHALALIKRAAASVNRELGVLPEDKANAIVAAADE
IIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGVRGESRKVHPNDDVNRGQSSNDVFPTAMHIAAALAIHAR
LLPALKRLRATLDEKSKAFAAIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESTLPHLYELAQGGTAVGTGLNAH
PQFAAAVADEIGRLTQLPFVTAPNKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGALSFNDHCAVGIEPNRSRID
TLLNESLMLVTALNPHIGYDKAAQIAKKAHKDGTTLKAAALALGYVSEAQFDEWVKPAEMIGKP
>Mature_463_residues
SEAVRMERDTFGEIAVPDARLWGAQTQRSLQNFRISTEKQSPELIHALALIKRAAASVNRELGVLPEDKANAIVAAADEI
IAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGVRGESRKVHPNDDVNRGQSSNDVFPTAMHIAAALAIHARL
LPALKRLRATLDEKSKAFAAIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESTLPHLYELAQGGTAVGTGLNAHP
QFAAAVADEIGRLTQLPFVTAPNKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSSI
MPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGALSFNDHCAVGIEPNRSRIDT
LLNESLMLVTALNPHIGYDKAAQIAKKAHKDGTTLKAAALALGYVSEAQFDEWVKPAEMIGKP

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.9067245119306, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=46.7532467532467, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=75.9825327510917, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=39.0350877192982, Blast_Score=342, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=63.4782608695652, Blast_Score=597, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=67.5925925925926, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=59.051724137931, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=60.3448275862069, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=60.3448275862069, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=59.2190889370933, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=59.6529284164859, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=52.7114967462039, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49623; Mature: 49492

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAVRMERDTFGEIAVPDARLWGAQTQRSLQNFRISTEKQSPELIHALALIKRAAASVN
CCCCHHCCHHCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RELGVLPEDKANAIVAAADEIIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
HHCCCCCCCCCCEEEEEHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GVRGESRKVHPNDDVNRGQSSNDVFPTAMHIAAALAIHARLLPALKRLRATLDEKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESTLPHLYELAQGGTAVGTGLNAH
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PQFAAAVADEIGRLTQLPFVTAPNKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLA
HHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGALSFNDHCAVGIEPNRSRIDTLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKDGTTLKAAALALGYVSEAQFDEWVKPAEMIGKP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
>Mature Secondary Structure 
SEAVRMERDTFGEIAVPDARLWGAQTQRSLQNFRISTEKQSPELIHALALIKRAAASVN
CCCHHCCHHCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RELGVLPEDKANAIVAAADEIIAGRHPDEFPLAVWQTGSGTQTNMNLNEVIANRASELLG
HHCCCCCCCCCCEEEEEHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GVRGESRKVHPNDDVNRGQSSNDVFPTAMHIAAALAIHARLLPALKRLRATLDEKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESTLPHLYELAQGGTAVGTGLNAH
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
PQFAAAVADEIGRLTQLPFVTAPNKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLA
HHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGALSFNDHCAVGIEPNRSRIDTLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCH
KAAQIAKKAHKDGTTLKAAALALGYVSEAQFDEWVKPAEMIGKP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]