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The map label for this gene is guaD [H]

Identifier: 238026502

GI number: 238026502

Start: 914403

End: 915716

Strand: Reverse

Name: guaD [H]

Synonym: bglu_1g08460

Alternate gene names: 238026502

Gene position: 915716-914403 (Counterclockwise)

Preceding gene: 238026503

Following gene: 238026500

Centisome position: 23.44

GC content: 72.68

Gene sequence:

>1314_bases
ATGACCCAATCCGCGTTTCGCGCCCGGCTGCTGACGTTTCGCGGCGACCCCGCGCACACCGACGAGGCCGCCGTCTTCGA
GGAGGACGGCCTGCTGATCGTCGATGCGGCGGGCCGGGTGGTCGCGGCCGGCGCCCACGCGGCGCTGGCCGGCCGCCTCG
CGCCCGATGCGCAGGTCACCACGCTCGGCGACAAGCTGATCGTGCCCGGCTTCATCGACGCGCACGTCCACTATCCGCAG
ACCGACATGATCGCCTCGCCGGCGCCGGGCCTGCTGCCGTGGCTCGACACCTACACGTTCCCGACCGAGCGGCGCTTCGC
GGACCCCGAGCATGCGCGCGAGGTGGCCTCGTTCTTCATCGACACGCTGCTGGCGAGCGGCACCACCACCGCGCTCGTCT
ACTGCACGGTCCACCGGCAGTCGGCCGAGGCGCTGTTCGAGGCGAGCGAGGCGAAGAACCTGCGGATGGCCGCGGGCAAG
GTGCTGATGGACCGCAACTGCCCCGAGTTCCTGCGCGACACGGCGCAGTCGGGCCACGACGACAGCGCCGCGCTGATCGA
GCGCTGGCACGGCCGCGGCCGGCAGATGTACGCGCTCACGCCGCGCTTCGCGCCGACCTCGACGCCGGCCCAGCTCGAGG
CCTGCGCCGCGCTCGCGCGCCGTCATCCCGACGTGTTCGTGCAGAGCCACGTGGCCGAGAACGTCGACGAGGTGAAGTGG
GCCGCCGAGCTGTTCCCCGGACACCGCAGCTATCTCGACATCTACGATCGCCACGGCCTGCTGCGCCCGCGTGCCGTCTA
CGGCCACTGCATCCACCTCGACGACGAGGACCGGCGCCGGATCGCCGAGACCGGCACGGTGATCGCGCATTGCCCGACCT
CGAACTTGTTCCTGGGCAGCGGCCTGTTCGATTTCGACCGCGCCACCGCGCAGCGCGTGCAGTTGTCGCTCGCCACCGAT
GTCGGCGGCGGCACCTCGTTCTCGATGCTGCAGACCATGAACGAGGCGCACAAGATCGCGCGGCTGTCAGGCCATCACCT
CAGCGCGACGCGGATGTTCTGGCTCGCCACGGCGGGCGCCGCGCGCGCGCTCGCGCTCGACGCGCAGGTCGGCACCCTCG
CGCCGCGCGCCGAGGCCGACTTCGTGGTGCTCGACCCGCGCGCCACGCCGCTGCTCGCGCGCCGCACCGCGCGCGCCGCC
TCGCTGGAGGAACTGCTGTTCGCGTTCGCGATGCTTGGCGACGACCGCGCGGTCCACAGCACCTGGTCGGCCGGCCGCTG
CGTGCATCGGCGCGGCGAGGCCGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
AAGCCGGCGATGTGGATCGTCGCCGCGCTTTCGGGCGTGCTGCTCGCGCAGCTTTGAGGCCGCCGGTGCGCCCCGTTCAT
CTGTCGCAGGAGTTTCGCCC

Downstream 100 bases:

>100_bases
GCCGCGGCGCAACGGCGCCGGCAACGGCGCAGCCGCGTCCGGACATGAGAAAGGCCCGCTGCGATCCCTCGCACCGGGCC
TTTCTCATGGGTTGCCGCCG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTQSAFRARLLTFRGDPAHTDEAAVFEEDGLLIVDAAGRVVAAGAHAALAGRLAPDAQVTTLGDKLIVPGFIDAHVHYPQ
TDMIASPAPGLLPWLDTYTFPTERRFADPEHAREVASFFIDTLLASGTTTALVYCTVHRQSAEALFEASEAKNLRMAAGK
VLMDRNCPEFLRDTAQSGHDDSAALIERWHGRGRQMYALTPRFAPTSTPAQLEACAALARRHPDVFVQSHVAENVDEVKW
AAELFPGHRSYLDIYDRHGLLRPRAVYGHCIHLDDEDRRRIAETGTVIAHCPTSNLFLGSGLFDFDRATAQRVQLSLATD
VGGGTSFSMLQTMNEAHKIARLSGHHLSATRMFWLATAGAARALALDAQVGTLAPRAEADFVVLDPRATPLLARRTARAA
SLEELLFAFAMLGDDRAVHSTWSAGRCVHRRGEAAAA

Sequences:

>Translated_437_residues
MTQSAFRARLLTFRGDPAHTDEAAVFEEDGLLIVDAAGRVVAAGAHAALAGRLAPDAQVTTLGDKLIVPGFIDAHVHYPQ
TDMIASPAPGLLPWLDTYTFPTERRFADPEHAREVASFFIDTLLASGTTTALVYCTVHRQSAEALFEASEAKNLRMAAGK
VLMDRNCPEFLRDTAQSGHDDSAALIERWHGRGRQMYALTPRFAPTSTPAQLEACAALARRHPDVFVQSHVAENVDEVKW
AAELFPGHRSYLDIYDRHGLLRPRAVYGHCIHLDDEDRRRIAETGTVIAHCPTSNLFLGSGLFDFDRATAQRVQLSLATD
VGGGTSFSMLQTMNEAHKIARLSGHHLSATRMFWLATAGAARALALDAQVGTLAPRAEADFVVLDPRATPLLARRTARAA
SLEELLFAFAMLGDDRAVHSTWSAGRCVHRRGEAAAA
>Mature_436_residues
TQSAFRARLLTFRGDPAHTDEAAVFEEDGLLIVDAAGRVVAAGAHAALAGRLAPDAQVTTLGDKLIVPGFIDAHVHYPQT
DMIASPAPGLLPWLDTYTFPTERRFADPEHAREVASFFIDTLLASGTTTALVYCTVHRQSAEALFEASEAKNLRMAAGKV
LMDRNCPEFLRDTAQSGHDDSAALIERWHGRGRQMYALTPRFAPTSTPAQLEACAALARRHPDVFVQSHVAENVDEVKWA
AELFPGHRSYLDIYDRHGLLRPRAVYGHCIHLDDEDRRRIAETGTVIAHCPTSNLFLGSGLFDFDRATAQRVQLSLATDV
GGGTSFSMLQTMNEAHKIARLSGHHLSATRMFWLATAGAARALALDAQVGTLAPRAEADFVVLDPRATPLLARRTARAAS
LEELLFAFAMLGDDRAVHSTWSAGRCVHRRGEAAAA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=439, Percent_Identity=30.5239179954442, Blast_Score=203, Evalue=3e-52,
Organism=Escherichia coli, GI1789249, Length=417, Percent_Identity=48.2014388489209, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319963, Length=417, Percent_Identity=30.6954436450839, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24643849, Length=448, Percent_Identity=32.3660714285714, Blast_Score=211, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 47549; Mature: 47418

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSAFRARLLTFRGDPAHTDEAAVFEEDGLLIVDAAGRVVAAGAHAALAGRLAPDAQVT
CCCHHHHHEEEEECCCCCCCCCCEEEECCCEEEEECCCCEEECCCHHHHHCCCCCCCEEE
TLGDKLIVPGFIDAHVHYPQTDMIASPAPGLLPWLDTYTFPTERRFADPEHAREVASFFI
ECCCCEECCCEEECEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
DTLLASGTTTALVYCTVHRQSAEALFEASEAKNLRMAAGKVLMDRNCPEFLRDTAQSGHD
HHHHHCCCCEEEEEEEEECHHHHHHHHHHHHCCHHHHHCHHEECCCCHHHHHHHHHCCCC
DSAALIERWHGRGRQMYALTPRFAPTSTPAQLEACAALARRHPDVFVQSHVAENVDEVKW
CHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH
AAELFPGHRSYLDIYDRHGLLRPRAVYGHCIHLDDEDRRRIAETGTVIAHCPTSNLFLGS
HHHHCCCCCHHHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHCCCEEEECCCCCEEEEC
GLFDFDRATAQRVQLSLATDVGGGTSFSMLQTMNEAHKIARLSGHHLSATRMFWLATAGA
CCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCC
ARALALDAQVGTLAPRAEADFVVLDPRATPLLARRTARAASLEELLFAFAMLGDDRAVHS
CEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
TWSAGRCVHRRGEAAAA
CCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TQSAFRARLLTFRGDPAHTDEAAVFEEDGLLIVDAAGRVVAAGAHAALAGRLAPDAQVT
CCHHHHHEEEEECCCCCCCCCCEEEECCCEEEEECCCCEEECCCHHHHHCCCCCCCEEE
TLGDKLIVPGFIDAHVHYPQTDMIASPAPGLLPWLDTYTFPTERRFADPEHAREVASFFI
ECCCCEECCCEEECEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
DTLLASGTTTALVYCTVHRQSAEALFEASEAKNLRMAAGKVLMDRNCPEFLRDTAQSGHD
HHHHHCCCCEEEEEEEEECHHHHHHHHHHHHCCHHHHHCHHEECCCCHHHHHHHHHCCCC
DSAALIERWHGRGRQMYALTPRFAPTSTPAQLEACAALARRHPDVFVQSHVAENVDEVKW
CHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH
AAELFPGHRSYLDIYDRHGLLRPRAVYGHCIHLDDEDRRRIAETGTVIAHCPTSNLFLGS
HHHHCCCCCHHHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHCCCEEEECCCCCEEEEC
GLFDFDRATAQRVQLSLATDVGGGTSFSMLQTMNEAHKIARLSGHHLSATRMFWLATAGA
CCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCC
ARALALDAQVGTLAPRAEADFVVLDPRATPLLARRTARAASLEELLFAFAMLGDDRAVHS
CEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
TWSAGRCVHRRGEAAAA
CCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]