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The map label for this gene is rfbD [H]

Identifier: 238026394

GI number: 238026394

Start: 786883

End: 787788

Strand: Direct

Name: rfbD [H]

Synonym: bglu_1g07290

Alternate gene names: 238026394

Gene position: 786883-787788 (Clockwise)

Preceding gene: 238026393

Following gene: 238026395

Centisome position: 20.14

GC content: 68.1

Gene sequence:

>906_bases
ATGTCGATGATGCATGCCTCCCGTACCATCCTGCTGACGGGCGTGAACGGCCAGGTCGGCCACGAACTCGCGCGCAGCCT
GCAAGGGCTCGGGCGCGTCGTGGCGCTCGATCGCCAGGCGCTCGATCTCGCCGATCCTGATGCGATTCGTCGTGTGATGC
GCGAGCTCGTGCCGGCATTGGTTGTCAATCCGGCCGCCTATACGGCCGTCGATCAGGCGGAAACCGATGTGGCGGGCGCG
ACGTGCCTGAACGTCGATGCGCCGGCCGTGTTTGCCGAGGAAGCCAGGCGCGCGGGGGCCGCGCTGGTGCATTATTCGAC
CGATTACGTCTATGCCGGCGAGGGCGAGGCGCGTTATGCCGAAACCGACCCCACCGGGCCGCGCAATGTCTACGGCCGCA
CCAAGCTCGAGGGCGAGCAGGCCATCGCGGCCTCGGGCTGCCGGCACCTGATCCTGCGCACCAGCTGGGTCTATGGCATG
CGCGGGCGCAATTTCCTCAGGACGATGTTGCGTCTCGGCGCCGAGCGCAGCGAACTGAACGTGGTGGCCGACCAGATCGG
TGCGCCCACCTGGTCGCGCACGATCGCCGAGCTGACGGCGGCGATTCTCGCGCAGTCGGTTTCGCCCGGCGTCTCGGCCG
ACGATTGGTGGGCTGCCCATTCAGGCGTTTTCCATCTGGCAGCCGGCGGCGAGACTTCCTGGCACGGCTTTGCCGAGGCG
ATTTTCGAGCAGGCGGGCGGTGAGCGCCGGCCTGCCGTGCGGCCGATTCCGGCCGCGTCGTATCCGACCCCGGCGGCGCG
CCCGTCGAATTCGCGGCTGTCGATGGACAAGCTCGAACGGACCTTCGGGCTGACCGTACCACATTGGCGCGAAGCGCTGC
GCCTATGCATGACGGCGGCCGATTGA

Upstream 100 bases:

>100_bases
CCGAGATCGGCATCGAATGGCCGATCGACTTCGAGCCGAAGCTGGCCGCCAAGGATGCGGCCGGTACGCGCTTCGCGCAG
GCCGAAGTCTACGCCTGAGG

Downstream 100 bases:

>100_bases
GTGCGGTGCCGCCGGCCGCGGCAGGCGTCGGCGCGGTCGTTGTCTTCTACCATCCCGATGCCGACTGCGTGGCGCGCGCC
AACCGCCTGGCGGCCGCGCT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSMMHASRTILLTGVNGQVGHELARSLQGLGRVVALDRQALDLADPDAIRRVMRELVPALVVNPAAYTAVDQAETDVAGA
TCLNVDAPAVFAEEARRAGAALVHYSTDYVYAGEGEARYAETDPTGPRNVYGRTKLEGEQAIAASGCRHLILRTSWVYGM
RGRNFLRTMLRLGAERSELNVVADQIGAPTWSRTIAELTAAILAQSVSPGVSADDWWAAHSGVFHLAAGGETSWHGFAEA
IFEQAGGERRPAVRPIPAASYPTPAARPSNSRLSMDKLERTFGLTVPHWREALRLCMTAAD

Sequences:

>Translated_301_residues
MSMMHASRTILLTGVNGQVGHELARSLQGLGRVVALDRQALDLADPDAIRRVMRELVPALVVNPAAYTAVDQAETDVAGA
TCLNVDAPAVFAEEARRAGAALVHYSTDYVYAGEGEARYAETDPTGPRNVYGRTKLEGEQAIAASGCRHLILRTSWVYGM
RGRNFLRTMLRLGAERSELNVVADQIGAPTWSRTIAELTAAILAQSVSPGVSADDWWAAHSGVFHLAAGGETSWHGFAEA
IFEQAGGERRPAVRPIPAASYPTPAARPSNSRLSMDKLERTFGLTVPHWREALRLCMTAAD
>Mature_300_residues
SMMHASRTILLTGVNGQVGHELARSLQGLGRVVALDRQALDLADPDAIRRVMRELVPALVVNPAAYTAVDQAETDVAGAT
CLNVDAPAVFAEEARRAGAALVHYSTDYVYAGEGEARYAETDPTGPRNVYGRTKLEGEQAIAASGCRHLILRTSWVYGMR
GRNFLRTMLRLGAERSELNVVADQIGAPTWSRTIAELTAAILAQSVSPGVSADDWWAAHSGVFHLAAGGETSWHGFAEAI
FEQAGGERRPAVRPIPAASYPTPAARPSNSRLSMDKLERTFGLTVPHWREALRLCMTAAD

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=292, Percent_Identity=27.3972602739726, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI11034825, Length=292, Percent_Identity=27.3972602739726, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1788352, Length=295, Percent_Identity=42.0338983050847, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32419; Mature: 32288

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMMHASRTILLTGVNGQVGHELARSLQGLGRVVALDRQALDLADPDAIRRVMRELVPAL
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHH
VVNPAAYTAVDQAETDVAGATCLNVDAPAVFAEEARRAGAALVHYSTDYVYAGEGEARYA
HCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCEEECCCCCCEEC
ETDPTGPRNVYGRTKLEGEQAIAASGCRHLILRTSWVYGMRGRNFLRTMLRLGAERSELN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
VVADQIGAPTWSRTIAELTAAILAQSVSPGVSADDWWAAHSGVFHLAAGGETSWHGFAEA
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHH
IFEQAGGERRPAVRPIPAASYPTPAARPSNSRLSMDKLERTFGLTVPHWREALRLCMTAA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCC
D
C
>Mature Secondary Structure 
SMMHASRTILLTGVNGQVGHELARSLQGLGRVVALDRQALDLADPDAIRRVMRELVPAL
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHH
VVNPAAYTAVDQAETDVAGATCLNVDAPAVFAEEARRAGAALVHYSTDYVYAGEGEARYA
HCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCEEEEECCCEEECCCCCCEEC
ETDPTGPRNVYGRTKLEGEQAIAASGCRHLILRTSWVYGMRGRNFLRTMLRLGAERSELN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHH
VVADQIGAPTWSRTIAELTAAILAQSVSPGVSADDWWAAHSGVFHLAAGGETSWHGFAEA
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHH
IFEQAGGERRPAVRPIPAASYPTPAARPSNSRLSMDKLERTFGLTVPHWREALRLCMTAA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]