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The map label for this gene is pyrC' [H]

Identifier: 238026388

GI number: 238026388

Start: 780911

End: 782188

Strand: Direct

Name: pyrC' [H]

Synonym: bglu_1g07230

Alternate gene names: 238026388

Gene position: 780911-782188 (Clockwise)

Preceding gene: 238026387

Following gene: 238026389

Centisome position: 19.99

GC content: 71.91

Gene sequence:

>1278_bases
ATGAAGATTCATATCAAGGGCGGCACGCTGGTCGATCCGGCCGCCGGCACGCAGCAAACGGCCGACGTCTATCTCGCGGC
CGGCAAGGTCGCCGCGATCGGGGCGGCGCCGGCCGATTTCCACGCGGCGAAGACGATCGACGCCGCCGGGCTGGTGGTCG
CGCCCGGTCTCGTCGATCTCTCCGCGCGGCTGCGCGAGCCCGGCAACGAGCACCGCGCCACGCTCGAGTCCGAGATGGCC
GCGGCGGTGGCGGGCGGCGTGACGAGCCTGGTCTGCCCGCCCGATACCGATCCCGTGCTCGACGAGCCGGGCCTCGTCGA
GATGCTCAAGTTTCGCGCGAGCAAGCTGCACCAGGCCCACGTCTATCCGCTCGGCGCGCTGACGGTGGGGCTCAGGGGCG
AGGTGATCACCGAGATGGTCGAGCTGACCGAGTCGGGCTGCATCGGCTTCACGCAGGCCAACGTGCCGATCCGCGACACG
CAGGTGCTGCTGCGCGCACTGCAGTACGCGAGCACCTACGGCTTCACGGTCTGGCTGCGCCCGCTCGACGCGTTCCTCGC
CAAGGGCGGGGTGGCCGCGAGCGGCGCGGTCGCGTCGCGGCTCGGGCTGTCGGGCGTGCCGGTGTCGGCCGAGACGATCG
CGCTGCACACGCTGTTCGAGCTGATGCGCGTGACGGGCGCGCGGGTCCACGTCGCACGGCTGTCGTCGGCGGCCGGCATC
GCGCTGGTGCGCGAGGCGAAAGCCGAAGGGCTGGCGGTGAGCTGCGACGTCAGCGCGAACCACCTGCACCTGATCGACGT
CGACATCGGCTACTTCGACGCGCAGTTCCGGCTCGATCCGCCGCTGCGCGCCGAGCGCGACCGCGAAGCGATCCGCGCCG
GGGTGGCCGACGGCACGATCGACGCGATCTGCTCGGACCACACGCCGGTGGACGACGATGAAAAGCTGCTGCCGTTCGCC
GAGGCGACGCCGGGCGCCACCGGCCTCGAACTGCTGCTGTCGTTGACGGTGAAGTGGGCCAACGAAGCGAACCTGCCGCT
CGCGCAGGCGCTGAGCCGCATCACCTCGGCGCCGGCCGACGTGCTGAAGCTGCCGGCCGGGCGCCTCGCGCCGGGCGCGG
TGGCCGACCTGGTGGTATTCGATCCGGCCGCGCACTGGCAGGTGGAGCCGCGCGCGCTGAAGAGCCAGGGCCACAACTCG
CCGTTCCTCGGCTACGAGCTGCCCGCCCAGGTGCGCGTGACGATCGTCGCCGGCCAGCTCGCCTTCGAACGTCGCTGA

Upstream 100 bases:

>100_bases
ATGGGCATCGTCGCCGGCACCAGCGACTGATCGCGGCGCTGGGCGGCATACGTCGCCCGGCCATCGAACTCAACGCATCC
AACGCATTCACAGGCAGCGC

Downstream 100 bases:

>100_bases
GCGGGGGCGCATCGTGAACCTGTTGCGCAAGCTGCGCCTGATCCTGCACCTGTTGCGCGGAATGGCGACCATCGCCCTGC
ATTTCGGCCGGGCCACGCCG

Product: dihydroorotase

Products: Allantoate; H+ [C]

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKIHIKGGTLVDPAAGTQQTADVYLAAGKVAAIGAAPADFHAAKTIDAAGLVVAPGLVDLSARLREPGNEHRATLESEMA
AAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRASKLHQAHVYPLGALTVGLRGEVITEMVELTESGCIGFTQANVPIRDT
QVLLRALQYASTYGFTVWLRPLDAFLAKGGVAASGAVASRLGLSGVPVSAETIALHTLFELMRVTGARVHVARLSSAAGI
ALVREAKAEGLAVSCDVSANHLHLIDVDIGYFDAQFRLDPPLRAERDREAIRAGVADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELLLSLTVKWANEANLPLAQALSRITSAPADVLKLPAGRLAPGAVADLVVFDPAAHWQVEPRALKSQGHNS
PFLGYELPAQVRVTIVAGQLAFERR

Sequences:

>Translated_425_residues
MKIHIKGGTLVDPAAGTQQTADVYLAAGKVAAIGAAPADFHAAKTIDAAGLVVAPGLVDLSARLREPGNEHRATLESEMA
AAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRASKLHQAHVYPLGALTVGLRGEVITEMVELTESGCIGFTQANVPIRDT
QVLLRALQYASTYGFTVWLRPLDAFLAKGGVAASGAVASRLGLSGVPVSAETIALHTLFELMRVTGARVHVARLSSAAGI
ALVREAKAEGLAVSCDVSANHLHLIDVDIGYFDAQFRLDPPLRAERDREAIRAGVADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELLLSLTVKWANEANLPLAQALSRITSAPADVLKLPAGRLAPGAVADLVVFDPAAHWQVEPRALKSQGHNS
PFLGYELPAQVRVTIVAGQLAFERR
>Mature_425_residues
MKIHIKGGTLVDPAAGTQQTADVYLAAGKVAAIGAAPADFHAAKTIDAAGLVVAPGLVDLSARLREPGNEHRATLESEMA
AAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRASKLHQAHVYPLGALTVGLRGEVITEMVELTESGCIGFTQANVPIRDT
QVLLRALQYASTYGFTVWLRPLDAFLAKGGVAASGAVASRLGLSGVPVSAETIALHTLFELMRVTGARVHVARLSSAAGI
ALVREAKAEGLAVSCDVSANHLHLIDVDIGYFDAQFRLDPPLRAERDREAIRAGVADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELLLSLTVKWANEANLPLAQALSRITSAPADVLKLPAGRLAPGAVADLVVFDPAAHWQVEPRALKSQGHNS
PFLGYELPAQVRVTIVAGQLAFERR

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=395, Percent_Identity=26.3291139240506, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=24.4493392070485, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786722, Length=457, Percent_Identity=28.4463894967177, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082175, Length=441, Percent_Identity=25.3968253968254, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=389, Percent_Identity=23.9074550128535, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24642586, Length=393, Percent_Identity=24.9363867684478, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18859883, Length=215, Percent_Identity=30.6976744186047, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.5 [C]

Molecular weight: Translated: 44549; Mature: 44549

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHIKGGTLVDPAAGTQQTADVYLAAGKVAAIGAAPADFHAAKTIDAAGLVVAPGLVDL
CEEEECCCCEECCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHCCCCCEEEECCHHHH
SARLREPGNEHRATLESEMAAAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRASKLHQAH
HHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHE
VYPLGALTVGLRGEVITEMVELTESGCIGFTQANVPIRDTQVLLRALQYASTYGFTVWLR
EEEEEHEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEH
PLDAFLAKGGVAASGAVASRLGLSGVPVSAETIALHTLFELMRVTGARVHVARLSSAAGI
HHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCC
ALVREAKAEGLAVSCDVSANHLHLIDVDIGYFDAQFRLDPPLRAERDREAIRAGVADGTI
CEEEHHCCCCEEEEEECCCCEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLELLLSLTVKWANEANLPLAQALSRITSAPAD
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHH
VLKLPAGRLAPGAVADLVVFDPAAHWQVEPRALKSQGHNSPFLGYELPAQVRVTIVAGQL
HHHCCCCCCCCCCCEEEEEECCCCCCEECHHHHHCCCCCCCCCCEECCCEEEEEEEEECE
AFERR
ECCCC
>Mature Secondary Structure
MKIHIKGGTLVDPAAGTQQTADVYLAAGKVAAIGAAPADFHAAKTIDAAGLVVAPGLVDL
CEEEECCCCEECCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHCCCCCEEEECCHHHH
SARLREPGNEHRATLESEMAAAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRASKLHQAH
HHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHE
VYPLGALTVGLRGEVITEMVELTESGCIGFTQANVPIRDTQVLLRALQYASTYGFTVWLR
EEEEEHEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEH
PLDAFLAKGGVAASGAVASRLGLSGVPVSAETIALHTLFELMRVTGARVHVARLSSAAGI
HHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCC
ALVREAKAEGLAVSCDVSANHLHLIDVDIGYFDAQFRLDPPLRAERDREAIRAGVADGTI
CEEEHHCCCCEEEEEECCCCEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLELLLSLTVKWANEANLPLAQALSRITSAPAD
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHH
VLKLPAGRLAPGAVADLVVFDPAAHWQVEPRALKSQGHNSPFLGYELPAQVRVTIVAGQL
HHHCCCCCCCCCCCEEEEEECCCCCCEECHHHHHCCCCCCCCCCEECCCEEEEEEEEECE
AFERR
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Allantoin; H2O [C]

Specific reaction: Allantoin + H2O --> Allantoate + H+ [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: Dithiothreitol; p-Chloromercuribenzene-sulphonic acid [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]