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The map label for this gene is groL [H]

Identifier: 238026380

GI number: 238026380

Start: 773286

End: 774926

Strand: Direct

Name: groL [H]

Synonym: bglu_1g07150

Alternate gene names: 238026380

Gene position: 773286-774926 (Clockwise)

Preceding gene: 238026379

Following gene: 238026382

Centisome position: 19.79

GC content: 64.17

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTGTTCGGCGATTCCGCCCGTTCCAAGATGGTTGAAGGCGTGAACATTCTCGCCAATGCAGT
GAAGGTCACGCTGGGTCCGAAGGGCCGCAACGTGGTGCTCGAGCGTTCGTTCGGCGGCCCGACGGTCACCAAGGACGGCG
TGTCGGTCGCCAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCGCAAATGGTCAAGGAAGTGGCTTCCAAG
ACCAGCGACAACGCAGGCGACGGCACGACGACGGCAACCGTCCTCGCGCAATCGATCGTCCGCGAAGGCATGAAGTACGT
CGCATCGGGCATGAACCCGATGGACCTCAAGCGCGGCATCGACAAGGCCGTCACCGCTGCCGTGGAAGAGCTGAAGAAGA
TCAGCAAGCCCTGCACGACCAACAAGGAAATCGCCCAGGTCGGCGCGATCTCGGCGAACAGCGACGCATCGATCGGTGAC
CGCATCGCCGAGGCGATGGACAAGGTCGGCAAGGAAGGCGTGATCACCGTCGAAGACGGCAAGTCGCTGGCCGACGAACT
CGATGTCGTCGAAGGCATGCAATTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGACAAGCAAGTCGCCG
TCCTCGAAAACCCGTTCGTGCTGCTGCACGACAAGAAGGTGTCGAACATCCGTGATCTGCTGCCGGTGCTGGAGCAGGTC
GCGAAGGCCGGCCGTCCGCTGCTGATCATCGCCGAAGACGTCGAAGGCGAAGCGCTGGCCACGCTGGTGGTCAACAACAT
CCGCGGCATCCTGAAGACCGTCGCCGTCAAGGCACCGGGCTTCGGCGACCGTCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACGGGCGGTCAGGTCATCGCCGAGGAAACCGGCCTCACGCTCGAGAAGGCGACGCTGGCCGAACTGGGCCAAGCC
AAGCGCATCGAAGTGGGCAAGGAAAACACGACGATCATCGATGGCGCCGGCGAAGCCGTCAACATCGAAGCGCGTGTCAA
GCAGATCCGCACGCAGATCGAGGAAGCGACCTCGGACTACGACCGCGAAAAGCTGCAAGAGCGCGTGGCGAAGCTGGCCG
GCGGCGTGGCGGTGATCAAGGTCGGCGCTGCGACCGAAGTGGAAATGAAGGAAAAGAAGGCACGCGTCGAAGATGCGCTG
CACGCCACGCGTGCCGCCGTTGAAGAAGGCATCGTGCCGGGCGGCGGCGTCGCGCTGATCCGCGCTCGCACCGCGATCGC
TGGCCTCGTCGGCATCAACGCCGACCAGAACGCCGGCATCAAGATCGTGCTGCGCGCGATGGAAGAGCCGCTGCGCCAGA
TCGTCACGAACGGCGGCGAAGAAGCGAGCGTCGTGGTCGCGGCGGTGGCTGCCGGCCAAGGCAACTACGGCTACAACGCG
GCGACGGGCGAGTACGTCGACATGGTCGAAGCCGGCGTGGTCGATCCGACGAAGGTCACGCGCACCGCGCTGCAGAACGC
TGCTTCGGTCGCCGGCCTGCTGCTGACGACGGATGCCGCCGTTGCCGAACTGCCGAAGGAAGACGCACCGATGCCGGGCG
GCATGCCGGGCGGCATGGGCGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
GGAGCTGCTGGTGATGCGCGAAGAAGACATCATGGCCGTGGTCAACGCGAACTGAGCGTTTGCGCCAGTATCCATTCCCA
AGCATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TCGACTTCGGTCGATTGCATCGGCGGGGCGCGCAGCGATGCGCGTCCCGTCTGCCAAAAAAAACCCGCAAGCGATTGCGG
GTTTTTTGTCGTTTGCGGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVTAAVEELKKISKPCTTNKEIAQVGAISANSDASIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIAGLVGINADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGQGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVTAAVEELKKISKPCTTNKEIAQVGAISANSDASIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIAGLVGINADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGQGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVTAAVEELKKISKPCTTNKEIAQVGAISANSDASIGDR
IAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAK
RIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVPGGGVALIRARTAIAGLVGINADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGQGNYGYNAA
TGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.4090909090909, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.4090909090909, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI24307939, Length=382, Percent_Identity=23.5602094240838, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI5453607, Length=553, Percent_Identity=22.9656419529837, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=76.1814744801512, Blast_Score=797, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.930056710775, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=51.8348623853211, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI25144674, Length=548, Percent_Identity=22.0802919708029, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.2813688212928, Blast_Score=537, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322446, Length=565, Percent_Identity=22.1238938053097, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=574, Percent_Identity=21.9512195121951, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=567, Percent_Identity=22.5749559082892, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.1821631878558, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.1821631878558, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=43.8181818181818, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=37.218045112782, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=37.218045112782, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI17647245, Length=503, Percent_Identity=23.4592445328032, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57158; Mature: 57027

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVTAAVEELKKISKPCTTNKEIAQVGAISANSDASIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIAGLVGINADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGQGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVTAAVEELKKISKPCTTNKEIAQVGAISANSDASIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIAGLVGINADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGQGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA