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The map label for this gene is galE [H]

Identifier: 238026322

GI number: 238026322

Start: 705686

End: 706579

Strand: Direct

Name: galE [H]

Synonym: bglu_1g06560

Alternate gene names: 238026322

Gene position: 705686-706579 (Clockwise)

Preceding gene: 238026321

Following gene: 238026323

Centisome position: 18.06

GC content: 63.2

Gene sequence:

>894_bases
ATGACGAAAGTACTCATCACGGGAATCGGCGGATTCACCGGCCGCCATCTCGCGCGTGAGCTGGAAGGGCGCGGCTGCGA
GGTGGAGGGGCTGGTCCATCGGCCGGTTGCCGGATTGGCATGGCCGGCCCATGTCTGCGATCTACTCGATCGCGAAGCCA
TGGGCGCGCTGATGGCGGCATGCCGTCCGGACGTGGTGATTCATCTGGCTGCGATCGCCTTCGTCGCGCATGGTGACGTC
GGGGCGGTCTACCAGACGAACATCATGGGGACGCGCAACCTGCTCGATGCGATCACATCGGCCGGCTGCCAGCCGCGTGC
GGTGCTGGTCGCCAGCAGCGCCAACGTCTATGGCAACACCGATCGCGGCGTGATCGACGAGTCGGTGCCGCCGAATCCCG
CAAACGACTACGCCATCAGCAAACTTGCGACGGAGCGCGTGGCGGCGCTCTGGAGCGATCGTTTGCCGATCACGATCGTG
CGCCCGTTCAATTACACCGGGCCAGGACAGGCCGCCAATTTTGTGCTGCCGAAGATCGTCGAGGGCTTCCGTAGCCGTTC
GCCGGTGCTCGAGCTCGGAAACCTGAACGTGATCCGCGATTTCTCCGATGTTCGGATGGTGGTGCGGGCCTACGCCGACC
TGATTGCCGGCACCTGGGCGGGCGAAACCTTCAATGTTTGTTCGGGCAACGGGTATTCGCTGCAGGATATTCTGCAGATG
ATGCGGTCACTCACGCAGCACGATCCCGAGATCCGCGTGAATCCGAATTTCGTGCGGGCCAATGAGGTCCATCGCTTGAT
CGGCGACAATCGTCGCCTTACCGCGGCGATTGGCTGCCTCGATATCGTGCCCTTGCAGGAGACCCTGGCTTGGATGCTGG
AGAGCGGGCGGTGA

Upstream 100 bases:

>100_bases
CGAACTTGGCTGGGAGCCCGCGACCACGCTGGAAGCCCTTTGCCAGATGATGGTGGAAGCGGATATTCGCCGCAATGAAA
CCGGATTTTCATTCTGACCG

Downstream 100 bases:

>100_bases
AAGTCGCGTTTGCGGTTGACGCGATCGTGCCGCCTTTGACTGGAATCGGGCGCTACGCCTGGGAGCTTGCCTGGCATTTC
ACGCACTTCGACGAGCCCTT

Product: GDP-6-deoxy-D-lyxo-4-hexulose reductase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTKVLITGIGGFTGRHLARELEGRGCEVEGLVHRPVAGLAWPAHVCDLLDREAMGALMAACRPDVVIHLAAIAFVAHGDV
GAVYQTNIMGTRNLLDAITSAGCQPRAVLVASSANVYGNTDRGVIDESVPPNPANDYAISKLATERVAALWSDRLPITIV
RPFNYTGPGQAANFVLPKIVEGFRSRSPVLELGNLNVIRDFSDVRMVVRAYADLIAGTWAGETFNVCSGNGYSLQDILQM
MRSLTQHDPEIRVNPNFVRANEVHRLIGDNRRLTAAIGCLDIVPLQETLAWMLESGR

Sequences:

>Translated_297_residues
MTKVLITGIGGFTGRHLARELEGRGCEVEGLVHRPVAGLAWPAHVCDLLDREAMGALMAACRPDVVIHLAAIAFVAHGDV
GAVYQTNIMGTRNLLDAITSAGCQPRAVLVASSANVYGNTDRGVIDESVPPNPANDYAISKLATERVAALWSDRLPITIV
RPFNYTGPGQAANFVLPKIVEGFRSRSPVLELGNLNVIRDFSDVRMVVRAYADLIAGTWAGETFNVCSGNGYSLQDILQM
MRSLTQHDPEIRVNPNFVRANEVHRLIGDNRRLTAAIGCLDIVPLQETLAWMLESGR
>Mature_296_residues
TKVLITGIGGFTGRHLARELEGRGCEVEGLVHRPVAGLAWPAHVCDLLDREAMGALMAACRPDVVIHLAAIAFVAHGDVG
AVYQTNIMGTRNLLDAITSAGCQPRAVLVASSANVYGNTDRGVIDESVPPNPANDYAISKLATERVAALWSDRLPITIVR
PFNYTGPGQAANFVLPKIVEGFRSRSPVLELGNLNVIRDFSDVRMVVRAYADLIAGTWAGETFNVCSGNGYSLQDILQMM
RSLTQHDPEIRVNPNFVRANEVHRLIGDNRRLTAAIGCLDIVPLQETLAWMLESGR

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788366, Length=348, Percent_Identity=25.2873563218391, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI48994969, Length=271, Percent_Identity=25.830258302583, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=336, Percent_Identity=23.2142857142857, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=336, Percent_Identity=23.2142857142857, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=336, Percent_Identity=23.2142857142857, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=336, Percent_Identity=23.2142857142857, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=336, Percent_Identity=23.2142857142857, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=336, Percent_Identity=22.0238095238095, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 32180; Mature: 32049

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLITGIGGFTGRHLARELEGRGCEVEGLVHRPVAGLAWPAHVCDLLDREAMGALMAA
CCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHCCCCHHCCCHHHHHHHHHHHHHHHHHHH
CRPDVVIHLAAIAFVAHGDVGAVYQTNIMGTRNLLDAITSAGCQPRAVLVASSANVYGNT
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
DRGVIDESVPPNPANDYAISKLATERVAALWSDRLPITIVRPFNYTGPGQAANFVLPKIV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHH
EGFRSRSPVLELGNLNVIRDFSDVRMVVRAYADLIAGTWAGETFNVCSGNGYSLQDILQM
HHHHCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
MRSLTQHDPEIRVNPNFVRANEVHRLIGDNRRLTAAIGCLDIVPLQETLAWMLESGR
HHHHHHCCCCEEECCCEECHHHHHHHHCCCCEEEEEHHHHHEEEHHHHHHHHHHCCC
>Mature Secondary Structure 
TKVLITGIGGFTGRHLARELEGRGCEVEGLVHRPVAGLAWPAHVCDLLDREAMGALMAA
CEEEEECCCCHHHHHHHHHHCCCCCCCCCHHCCCCHHCCCHHHHHHHHHHHHHHHHHHH
CRPDVVIHLAAIAFVAHGDVGAVYQTNIMGTRNLLDAITSAGCQPRAVLVASSANVYGNT
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
DRGVIDESVPPNPANDYAISKLATERVAALWSDRLPITIVRPFNYTGPGQAANFVLPKIV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHH
EGFRSRSPVLELGNLNVIRDFSDVRMVVRAYADLIAGTWAGETFNVCSGNGYSLQDILQM
HHHHCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHH
MRSLTQHDPEIRVNPNFVRANEVHRLIGDNRRLTAAIGCLDIVPLQETLAWMLESGR
HHHHHHCCCCEEECCCEECHHHHHHHHCCCCEEEEEHHHHHEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]