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The map label for this gene is gmd [H]

Identifier: 238026321

GI number: 238026321

Start: 704648

End: 705682

Strand: Direct

Name: gmd [H]

Synonym: bglu_1g06550

Alternate gene names: 238026321

Gene position: 704648-705682 (Clockwise)

Preceding gene: 238026320

Following gene: 238026322

Centisome position: 18.04

GC content: 60.77

Gene sequence:

>1035_bases
GTGAAAAAAGCGATCATTACCGGCATCACCGGCCAGGACGGCGCTTATCTCGCCCAGCTGCTGCTGGAGAAGGGCTATAC
CGTCTATGGTACGTATCGCCGAACCAGTTCGGTCAACTTCTGGCGTATCGCCGAAATCGGTGTCGAGCATCATCCGAACC
TGCACCTCGTCGAGTACGATCTCACCGACCTGAGCTCGAGTATCCGCCTGTTGCAAAGCACGGGTGCCACGGAAGTCTAT
AACCTCGCGGCGCAGAGCTTCGTCGGTGTCTCGTTCGACCAGCCGGTGACGACCGCGGAAATCACCGGCATCGGCCCCCT
GAACCTGCTCGAAGCCATTCGCATCGTCAATCCCGCGATTCGCTTCTATCAGGCCAGCACGTCGGAAATGTTCGGCAAGG
TGCAAACGATCCCGCAGGTCGAAAGCACGCCCTTCTATCCGCGTAGCCCGTATGGCGTGGCGAAGCTGTATGCCCACTGG
ATGACGATCAATTACCGCGAAAGCTACGATATCTTCGGCTGCAGCGGCATCCTGTTCAACCATGAATCGCCGCTGCGCGG
TCGCGAGTTCGTGACGCGCAAGATCACCGACACCATCGCCAAGATCCGGCTCGGCAAGGCCGACGTGCTGGAACTCGGCA
ATCTCGATGCCAAGCGCGACTGGGGCTACGCCAAGGAGTACGTGGAAGGCATGTGGCGGATGCTGCAGGCAGACCGGGCC
GATACCTATGTGCTTGCCACCAATCGGACCGAGACGGTGCGGGATTTCGTTGCGATGGCCGCACGCGCGGCCGGCTTCGA
GCTCGCCTGGCAAGGCAGCGGCCTGCAGGAGGTCGGTGTCGATACGGCCAGCGGCAAGGCGATCGTGAAGATCAATCCGA
AGTTCCATCGCCCGGCCGAGGTCGACCTGCTGATCGGCGATCCGGCCAAGGCGCGAGCCGAACTTGGCTGGGAGCCCGCG
ACCACGCTGGAAGCCCTTTGCCAGATGATGGTGGAAGCGGATATTCGCCGCAATGAAACCGGATTTTCATTCTGA

Upstream 100 bases:

>100_bases
CCTATATTGCCCTCAAGCGAGAGCGCGAGGATGCGCGCGGCGCGCATGAAACTACCGAATCCGCCGTCAAAGTTTAATTT
TCATTCGAGGAAGGAAGTTC

Downstream 100 bases:

>100_bases
CCGATGACGAAAGTACTCATCACGGGAATCGGCGGATTCACCGGCCGCCATCTCGCGCGTGAGCTGGAAGGGCGCGGCTG
CGAGGTGGAGGGGCTGGTCC

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKKAIITGITGQDGAYLAQLLLEKGYTVYGTYRRTSSVNFWRIAEIGVEHHPNLHLVEYDLTDLSSSIRLLQSTGATEVY
NLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQTIPQVESTPFYPRSPYGVAKLYAHW
MTINYRESYDIFGCSGILFNHESPLRGREFVTRKITDTIAKIRLGKADVLELGNLDAKRDWGYAKEYVEGMWRMLQADRA
DTYVLATNRTETVRDFVAMAARAAGFELAWQGSGLQEVGVDTASGKAIVKINPKFHRPAEVDLLIGDPAKARAELGWEPA
TTLEALCQMMVEADIRRNETGFSF

Sequences:

>Translated_344_residues
MKKAIITGITGQDGAYLAQLLLEKGYTVYGTYRRTSSVNFWRIAEIGVEHHPNLHLVEYDLTDLSSSIRLLQSTGATEVY
NLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQTIPQVESTPFYPRSPYGVAKLYAHW
MTINYRESYDIFGCSGILFNHESPLRGREFVTRKITDTIAKIRLGKADVLELGNLDAKRDWGYAKEYVEGMWRMLQADRA
DTYVLATNRTETVRDFVAMAARAAGFELAWQGSGLQEVGVDTASGKAIVKINPKFHRPAEVDLLIGDPAKARAELGWEPA
TTLEALCQMMVEADIRRNETGFSF
>Mature_344_residues
MKKAIITGITGQDGAYLAQLLLEKGYTVYGTYRRTSSVNFWRIAEIGVEHHPNLHLVEYDLTDLSSSIRLLQSTGATEVY
NLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQTIPQVESTPFYPRSPYGVAKLYAHW
MTINYRESYDIFGCSGILFNHESPLRGREFVTRKITDTIAKIRLGKADVLELGNLDAKRDWGYAKEYVEGMWRMLQADRA
DTYVLATNRTETVRDFVAMAARAAGFELAWQGSGLQEVGVDTASGKAIVKINPKFHRPAEVDLLIGDPAKARAELGWEPA
TTLEALCQMMVEADIRRNETGFSF

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=341, Percent_Identity=50.4398826979472, Blast_Score=353, Evalue=9e-98,
Organism=Escherichia coli, GI1788366, Length=349, Percent_Identity=51.0028653295129, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=24.5664739884393, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=54.5454545454545, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=53.3724340175953, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=53.3724340175953, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=53.3724340175953, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=53.3724340175953, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=53.3724340175953, Blast_Score=366, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24158427, Length=340, Percent_Identity=52.0588235294118, Blast_Score=358, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38337; Mature: 38337

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIITGITGQDGAYLAQLLLEKGYTVYGTYRRTSSVNFWRIAEIGVEHHPNLHLVEYD
CCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCCCCEEEEEEC
LTDLSSSIRLLQSTGATEVYNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RFYQASTSEMFGKVQTIPQVESTPFYPRSPYGVAKLYAHWMTINYRESYDIFGCSGILFN
HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCEEEECEEEEC
HESPLRGREFVTRKITDTIAKIRLGKADVLELGNLDAKRDWGYAKEYVEGMWRMLQADRA
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
DTYVLATNRTETVRDFVAMAARAAGFELAWQGSGLQEVGVDTASGKAIVKINPKFHRPAE
CEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCE
VDLLIGDPAKARAELGWEPATTLEALCQMMVEADIRRNETGFSF
EEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKAIITGITGQDGAYLAQLLLEKGYTVYGTYRRTSSVNFWRIAEIGVEHHPNLHLVEYD
CCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCCCCEEEEEEC
LTDLSSSIRLLQSTGATEVYNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RFYQASTSEMFGKVQTIPQVESTPFYPRSPYGVAKLYAHWMTINYRESYDIFGCSGILFN
HHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCEEEECEEEEC
HESPLRGREFVTRKITDTIAKIRLGKADVLELGNLDAKRDWGYAKEYVEGMWRMLQADRA
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
DTYVLATNRTETVRDFVAMAARAAGFELAWQGSGLQEVGVDTASGKAIVKINPKFHRPAE
CEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCE
VDLLIGDPAKARAELGWEPATTLEALCQMMVEADIRRNETGFSF
EEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]