Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 238026305

GI number: 238026305

Start: 681146

End: 681679

Strand: Reverse

Name: folK [H]

Synonym: bglu_1g06390

Alternate gene names: 238026305

Gene position: 681679-681146 (Counterclockwise)

Preceding gene: 238026306

Following gene: 238026304

Centisome position: 17.45

GC content: 67.6

Gene sequence:

>534_bases
ATGACGGTTGCTTATCTCGGGCTGGGCGCGAATCTCGGCGATGCGCGCCAGGCGTTGAAGGACGCGGTGGTCTGCCTCGC
GCAGCAATGCACGTCGATCACCGTGATCGGCAAGTCGAGCCTGTACCGGACGGCCCCCGTGGATGCCGGCGGCGACGACT
ACTACAACTGCGCCGTCAAGGTCGACACGCGTTTGCCGGCCCGTGAATTGCTCCGGCTCTGCCAGCAGATCGAGCACCAT
TTCGGCCGCGAGCGGCCGTTCCCCAATGCGCCGCGTACGCTCGACATCGACATCCTGCTGTACGGCGACCATCTGATCGA
CGAGCCCGATCTGGTCGTGCCGCACCCGCGCCTGACCGCGCGCGCGTTCGTGCTGGTGCCGCTGCTCGAACTCGATCCGG
CGCTCATGATTCCCTCGCGGGGCGCCGCCCAGGCGTTCCTCGCCGCGGTGGCCGACCAGCGCATCGAGAAGGTGCAGACC
TGCCAGTGCCTGCTGGCGATGAAGAGCGCGAACGAGTCGCGCCGCTGCCGATGA

Upstream 100 bases:

>100_bases
GCGGCGCGCGCAACCGCAGGCCGGCCGACGGCACCGTGCAACAGGCCGACGCCCAGGACGCGCAGGACTGAGCCGTCGAA
CGACGTAGGATGTGGATGCC

Downstream 100 bases:

>100_bases
ACGCGACGCCGCTGACCGTCACGCCGCCCGACCCGCGCCCGCCCCACCGCTACCTCGCGATCGAGGGGCCGATCGGCGTC
GGCAAGACCTCGCTAGCCAC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTVAYLGLGANLGDARQALKDAVVCLAQQCTSITVIGKSSLYRTAPVDAGGDDYYNCAVKVDTRLPARELLRLCQQIEHH
FGRERPFPNAPRTLDIDILLYGDHLIDEPDLVVPHPRLTARAFVLVPLLELDPALMIPSRGAAQAFLAAVADQRIEKVQT
CQCLLAMKSANESRRCR

Sequences:

>Translated_177_residues
MTVAYLGLGANLGDARQALKDAVVCLAQQCTSITVIGKSSLYRTAPVDAGGDDYYNCAVKVDTRLPARELLRLCQQIEHH
FGRERPFPNAPRTLDIDILLYGDHLIDEPDLVVPHPRLTARAFVLVPLLELDPALMIPSRGAAQAFLAAVADQRIEKVQT
CQCLLAMKSANESRRCR
>Mature_176_residues
TVAYLGLGANLGDARQALKDAVVCLAQQCTSITVIGKSSLYRTAPVDAGGDDYYNCAVKVDTRLPARELLRLCQQIEHHF
GRERPFPNAPRTLDIDILLYGDHLIDEPDLVVPHPRLTARAFVLVPLLELDPALMIPSRGAAQAFLAAVADQRIEKVQTC
QCLLAMKSANESRRCR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=37.1069182389937, Blast_Score=94, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=37.037037037037, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19467; Mature: 19336

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYLGLGANLGDARQALKDAVVCLAQQCTSITVIGKSSLYRTAPVDAGGDDYYNCAVK
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEECCCCCCCCCEEEEEEE
VDTRLPARELLRLCQQIEHHFGRERPFPNAPRTLDIDILLYGDHLIDEPDLVVPHPRLTA
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCHHH
RAFVLVPLLELDPALMIPSRGAAQAFLAAVADQRIEKVQTCQCLLAMKSANESRRCR
HHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVAYLGLGANLGDARQALKDAVVCLAQQCTSITVIGKSSLYRTAPVDAGGDDYYNCAVK
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEECCCCCCCCCEEEEEEE
VDTRLPARELLRLCQQIEHHFGRERPFPNAPRTLDIDILLYGDHLIDEPDLVVPHPRLTA
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCHHH
RAFVLVPLLELDPALMIPSRGAAQAFLAAVADQRIEKVQTCQCLLAMKSANESRRCR
HHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]