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The map label for this gene is panB [H]

Identifier: 238026303

GI number: 238026303

Start: 679604

End: 680419

Strand: Reverse

Name: panB [H]

Synonym: bglu_1g06370

Alternate gene names: 238026303

Gene position: 680419-679604 (Counterclockwise)

Preceding gene: 238026304

Following gene: 238026298

Centisome position: 17.42

GC content: 70.1

Gene sequence:

>816_bases
ATGACCTACCTCCAGGAATCGAGCCGCGCGGCCGTGACCGTGCCGAAACTGCAGGCGATGCGCGACGCGGGCGAAAAGAT
CGCGATGCTGACCTGCTACGACGCGAGCTTCGCGTCGCTGCTCGATCGCGCCGGCGTCGACGCGCTGCTGATCGGCGACT
CGCTCGGCAACGTGCTGCAAGGCCAGACCACCACGCTGCCGGTCACGCTCGACGAGATCGCCTACCACACCGCCTGCGTG
GCGCGCGCGCAGCCGCGCGCGCTGATCGTCGCCGACCTGCCGTTCGGCACCTACGGCACGCCGGCCGAGGCGTTCGCGAG
TTCGGTCAAGCTGATGCGCGCCGGCGCCCAGATGGTCAAGCTGGAAGGCGGCGAATGGCTCGCCGACACGGTGCGCTTCC
TGGTCGAGCGTGCCGTGCCGGTGTGTCCGCACCTCGGGCTCACGCCGCAGTCGGTGCATGCGCTCGGCGGCTTCAAGGTG
CAGGGCAAGACGGAGGCCGGCGCCGCGCAGCTGCTGCGCGACGCGCAGGCGCTGGAACAGGCCGGCGCGCAGCTGATGGT
GCTCGAAGCGGTGCCGACGCTGGTGGCCTCGGAGCTGACCGCGCAGATCCGCACGCCGACCATCGGCATCGGCGCCGGCA
TCAACTGCTCGGGCCAGGTGCTGGTGCTGCACGACATGCTCGGCATCTTCCCCGGCAAGCGGCCGCGCTTCGTGAAGGAT
TTCATGCAGGGCCAGCCGAGCATCTTCGCGGCTGTCGAAGCCTACGTGCGCGCCGTCAAGGACGGCAGCTTCCCCGGCCC
GGAGCATTCGTTCTGA

Upstream 100 bases:

>100_bases
GAGACGATGCGCGGGCGCAAGGAATCCTTCGTCAAGGGCGGCGTCGGCCGCTGAGGCGGTTCGCGGCGCCGCCTGTTTTC
TCCACGAAACCGGACCCCCC

Downstream 100 bases:

>100_bases
CGAGGCCGCGAGGCGCGCCGCCCGGACCTCAGCAGGCGCGCCGCAGCGTGGCCATGACGGCGCCGCGCAGCGCGTTGCAG
ACCATCAGCGCCTCGGCGCG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTYLQESSRAAVTVPKLQAMRDAGEKIAMLTCYDASFASLLDRAGVDALLIGDSLGNVLQGQTTTLPVTLDEIAYHTACV
ARAQPRALIVADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLADTVRFLVERAVPVCPHLGLTPQSVHALGGFKV
QGKTEAGAAQLLRDAQALEQAGAQLMVLEAVPTLVASELTAQIRTPTIGIGAGINCSGQVLVLHDMLGIFPGKRPRFVKD
FMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF

Sequences:

>Translated_271_residues
MTYLQESSRAAVTVPKLQAMRDAGEKIAMLTCYDASFASLLDRAGVDALLIGDSLGNVLQGQTTTLPVTLDEIAYHTACV
ARAQPRALIVADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLADTVRFLVERAVPVCPHLGLTPQSVHALGGFKV
QGKTEAGAAQLLRDAQALEQAGAQLMVLEAVPTLVASELTAQIRTPTIGIGAGINCSGQVLVLHDMLGIFPGKRPRFVKD
FMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF
>Mature_270_residues
TYLQESSRAAVTVPKLQAMRDAGEKIAMLTCYDASFASLLDRAGVDALLIGDSLGNVLQGQTTTLPVTLDEIAYHTACVA
RAQPRALIVADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLADTVRFLVERAVPVCPHLGLTPQSVHALGGFKVQ
GKTEAGAAQLLRDAQALEQAGAQLMVLEAVPTLVASELTAQIRTPTIGIGAGINCSGQVLVLHDMLGIFPGKRPRFVKDF
MQGQPSIFAAVEAYVRAVKDGSFPGPEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=259, Percent_Identity=52.8957528957529, Blast_Score=279, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6319653, Length=278, Percent_Identity=34.8920863309352, Blast_Score=172, Evalue=5e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28649; Mature: 28518

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLQESSRAAVTVPKLQAMRDAGEKIAMLTCYDASFASLLDRAGVDALLIGDSLGNVLQ
CCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCEEEECCHHHHHHC
GQTTTLPVTLDEIAYHTACVARAQPRALIVADLPFGTYGTPAEAFASSVKLMRAGAQMVK
CCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLADTVRFLVERAVPVCPHLGLTPQSVHALGGFKVQGKTEAGAAQLLRDAQALEQ
ECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
AGAQLMVLEAVPTLVASELTAQIRTPTIGIGAGINCSGQVLVLHDMLGIFPGKRPRFVKD
CCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEHHHHHHHCCCCCCHHHHH
FMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TYLQESSRAAVTVPKLQAMRDAGEKIAMLTCYDASFASLLDRAGVDALLIGDSLGNVLQ
CCCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCEEEECCHHHHHHC
GQTTTLPVTLDEIAYHTACVARAQPRALIVADLPFGTYGTPAEAFASSVKLMRAGAQMVK
CCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLADTVRFLVERAVPVCPHLGLTPQSVHALGGFKVQGKTEAGAAQLLRDAQALEQ
ECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
AGAQLMVLEAVPTLVASELTAQIRTPTIGIGAGINCSGQVLVLHDMLGIFPGKRPRFVKD
CCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEHHHHHHHCCCCCCHHHHH
FMQGQPSIFAAVEAYVRAVKDGSFPGPEHSF
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA