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The map label for this gene is pntAA [H]

Identifier: 238026257

GI number: 238026257

Start: 620282

End: 621427

Strand: Direct

Name: pntAA [H]

Synonym: bglu_1g05900

Alternate gene names: 238026257

Gene position: 620282-621427 (Clockwise)

Preceding gene: 238026253

Following gene: 238026258

Centisome position: 15.88

GC content: 74.43

Gene sequence:

>1146_bases
ATGCTGATCGGAGTGCCCGCCGAGACGAGGGCGAACGAGGCGCGCGTTGCCGCGACGCCGGAAACCATCAAGAAATACGT
GGCGGCCGGCCACGCCGTGACGGTCGAACGCGGCGCCGGCGCCGCCGCCAGTTACCCCGACGAGGCCTATGCCGCGGCCG
GGGCGACGCTCGGCGAGCGCGCGGCCGCGTTCGGTGCCGAGATCGTGCTGAAGGTGCAGGCGCCGGAGCCGGCCGAGCTG
CCGCTGCTCAAGCGCGGCGCCGTGCTGGTCGGCATGCTCGAGCCGTTCGACGCCGCCCAGGCCCAGCGGCTCGCGGCGGC
CGGCGTGACGGGCTTCGCGCTCGAGGCCGCGCCGCGCACCACGCGCGCGCAGAGCCTCGACGTGCTGTCCTCGCAGGCCA
ACATCGCCGGCTACAGGGCGGTGCTGGTGGCGGCCTCGCTCTACCCGCGCTTCCTGCCGATGCTGATGACCGCCGCAGGC
ACCGTCAAGGCCGCCCGCGTGCTGGTGCTGGGCGCTGGCGTGGCGGGGCTGCAGGCGATCGCCACCGCCAAGCGGCTGGG
CGCCGTGATCGAGGCGTCCGACGTGCGGCCGGCCGTGAAGGAGCAGATCGAATCGCTCGGCGCGAAGTTCCTCGACGTGC
CGTTCGAGACCGACGAGGAGCGCGAGGCCGCGCAGGGCACCGGCGGCTACGCGCGGCCGATGCCGCCTTCATGGCTGGCG
CGCCAGGCCGCGCTCGTGCACGAGCGCGCCAAGCAGGCCGACATCGTGATCACCACCGCGCTGATTCCGGGGCGCCCGGC
GCCCACGCTGATCGCTGCCGAGACGGTGGCGGCCATGAAGCCGGGCGCGGTGCTGGTCGATCTGGCCGCCGGCCGCGGCG
CCGAGGTGGACGGCACCGGCCGGCGCGGCGGCAACTGCCCGCTCACCGTCGCCGACCAGGTGGTGGTCGCGCACGGCGTG
ACGATCGCCGGCCACACCAATCTCGCCGCCCAGGTGCCGGCCGACGCCTCGGCGCTCTACGCGCGCAATCTGGCCGACTT
CCTGAAGCTCATCATCGGCCCGGACGGCGCGCTGCGGATCGACCCGGCCGACGACATCGTCGCCGCGACGCTGCTCTGCC
GCGACGGCGAAGTGCTGCGCAAATAA

Upstream 100 bases:

>100_bases
TTGGCGCGTGGAACACGCCGTTGCTTTCGGGCCGGTTGCCGCTTTCCGGCTCGCCATCACAATCGAAATCAATAACAGAG
CGCAAGCTGGAGGGATCACG

Downstream 100 bases:

>100_bases
TCGAGGAGACCCATGGAAATCATCAATCACACCGTGATCAACGTGATCATCTTCGTGCTGGCCGTCTACGTCGGCTACCA
CGTGGTCTGGAACGTCACCC

Product: Alanine dehydrogenase/PNT domain-containing protein

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MLIGVPAETRANEARVAATPETIKKYVAAGHAVTVERGAGAAASYPDEAYAAAGATLGERAAAFGAEIVLKVQAPEPAEL
PLLKRGAVLVGMLEPFDAAQAQRLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYRAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGTGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLIAAETVAAMKPGAVLVDLAAGRGAEVDGTGRRGGNCPLTVADQVVVAHGV
TIAGHTNLAAQVPADASALYARNLADFLKLIIGPDGALRIDPADDIVAATLLCRDGEVLRK

Sequences:

>Translated_381_residues
MLIGVPAETRANEARVAATPETIKKYVAAGHAVTVERGAGAAASYPDEAYAAAGATLGERAAAFGAEIVLKVQAPEPAEL
PLLKRGAVLVGMLEPFDAAQAQRLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYRAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGTGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLIAAETVAAMKPGAVLVDLAAGRGAEVDGTGRRGGNCPLTVADQVVVAHGV
TIAGHTNLAAQVPADASALYARNLADFLKLIIGPDGALRIDPADDIVAATLLCRDGEVLRK
>Mature_381_residues
MLIGVPAETRANEARVAATPETIKKYVAAGHAVTVERGAGAAASYPDEAYAAAGATLGERAAAFGAEIVLKVQAPEPAEL
PLLKRGAVLVGMLEPFDAAQAQRLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYRAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGTGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLIAAETVAAMKPGAVLVDLAAGRGAEVDGTGRRGGNCPLTVADQVVVAHGV
TIAGHTNLAAQVPADASALYARNLADFLKLIIGPDGALRIDPADDIVAATLLCRDGEVLRK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=394, Percent_Identity=36.5482233502538, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI122939153, Length=394, Percent_Identity=36.5482233502538, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1787887, Length=381, Percent_Identity=44.0944881889764, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=377, Percent_Identity=41.6445623342175, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38999; Mature: 38999

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGVPAETRANEARVAATPETIKKYVAAGHAVTVERGAGAAASYPDEAYAAAGATLGER
CEECCCCCCCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHHH
AAAFGAEIVLKVQAPEPAELPLLKRGAVLVGMLEPFDAAQAQRLAAAGVTGFALEAAPRT
HHHCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYRAVLVAASLYPRFLPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGTGGYARPMPPSWLA
HHHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLIAAETVAAMKPGAVLVDLAAGRGAEVDGTG
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHCCCCEEEEEECCCCCCCCCCCC
RRGGNCPLTVADQVVVAHGVTIAGHTNLAAQVPADASALYARNLADFLKLIIGPDGALRI
CCCCCCCEEHHCCEEECCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEE
DPADDIVAATLLCRDGEVLRK
CCCHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure
MLIGVPAETRANEARVAATPETIKKYVAAGHAVTVERGAGAAASYPDEAYAAAGATLGER
CEECCCCCCCCCCCEEEECHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCHHHHH
AAAFGAEIVLKVQAPEPAELPLLKRGAVLVGMLEPFDAAQAQRLAAAGVTGFALEAAPRT
HHHCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYRAVLVAASLYPRFLPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGTGGYARPMPPSWLA
HHHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLIAAETVAAMKPGAVLVDLAAGRGAEVDGTG
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHCCCCEEEEEECCCCCCCCCCCC
RRGGNCPLTVADQVVVAHGVTIAGHTNLAAQVPADASALYARNLADFLKLIIGPDGALRI
CCCCCCCEEHHCCEEECCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEE
DPADDIVAATLLCRDGEVLRK
CCCHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]