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The map label for this gene is accC [H]

Identifier: 238026175

GI number: 238026175

Start: 533833

End: 535200

Strand: Reverse

Name: accC [H]

Synonym: bglu_1g05060

Alternate gene names: 238026175

Gene position: 535200-533833 (Counterclockwise)

Preceding gene: 238026176

Following gene: 238026174

Centisome position: 13.7

GC content: 64.91

Gene sequence:

>1368_bases
ATGTTTGAAAAAATCCTCATTGCCAATCGCGGCGAGATCGCATTGCGCATTCAGCGCGCATGCCGCGAGTTGGGCGTCAA
GACGGTCGTCGTATACTCGGAAGCCGACAAGGAAGCCAAGTACGTGAAGCTGGCGGACGAGGCGGTCTGCATCGGCCCCG
CTCCGTCGAACCTCAGCTATCTGAACATGCCGGCGCTGATCAGCGCGGCCGAAGTCACCGATGCCCAGGCGATCCACCCG
GGCTACGGCTTCCTGTCCGAGAACGCCGATTTCGCCGAGCGCGTCGAGCAGTCAGGCTTCACGTTCATCGGCCCGCGCCC
GGACACGATCCGCCTGATGGGTGACAAGGTCACCGCCAAGCAGACCATGATCCGCACCGGCGTGCCGTGCGTGCCGGGCT
CGGAAGGCGCGCTGCCCGACGATCCGAAGGAAATCGTGAAGATCGCGCGCGCGATCGGCTATCCGGTCATCATCAAGGCC
TCGGGCGGCGGCGGTGGCCGCGGCATGCGCGTCGTGCATACCGAGGCGGCGCTCGTCAACGCCGTCAACATGACGCGCGA
GGAGGCCGGCCGGGCGTTCGGCAACCCGCAGGTGTACATGGAGAAGTATCTCGAGAATCCGCGTCACATCGAGATCCAGG
TGCTGGCCGACGCGCACAAGAACGCGCTCTGGCTCGGCGAACGCGACTGCTCGATGCAGCGCCGCCACCAGAAGGTGATC
GAGGAAGCGCCGGCGCCCGGCATCGCGCGCCGCCTGATCGACCGGATCGGCGACCGCTGCGCCGACGCCTGCAAGAAGAT
GGGCTATCTGGGCGCGGGCACCTTCGAGTTCCTCTACGAGAACAACGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCACCCGGTCACCGAGCTGATCACGGGCATCGACATCGTGCAGGAACAGATCAAGATCGCCGCCGGCGAGAAG
CTCGCGATCCGCCAGCGCGACATCCAGTTCCGCGGCCACGCGATCGAATGCCGGATCAACGCCGAGGATCCGTTCAAGTT
CACGCCGTCGCCGGGCCGGATCACGTCGTGGCACACGCCGGGCGGCCCTGGCGTGCGTGTCGATTCGCATGCCTACAACG
GCTATTTCGTGCCGCCGAACTACGATTCGATGATCGGCAAGCTGATCGCCTATGGCGCGACGCGCGAGCAGGCCATCCAG
CGCATGCGCATCGCGCTGTCGGAAATGGTGGTCGAGGGCATCCAGACCAACATCCCGCTGCATCGGGAACTGATGCTCGA
TTCGAAGTTCGTCGAGGGCGGCACCAGCATCCATTACCTCGAAGGCCGGCTCGCCGCGAAGCAGCAGGTCGCGCCGGAAG
AGGCCTGA

Upstream 100 bases:

>100_bases
GGCCAGGCGGTCGAATACGGCCAGCCGCTGTTCGTGGTCGGCTAAAGCCGAACGCGACGCCTCGCGCCAGAGCGCGTCAC
CGAAAAGACGAATATCCGCT

Downstream 100 bases:

>100_bases
GCATGAGCTATCGGGAACTCGTCGCCGAGCTGGCGCGCGAACATGCGGAAGCGCTGTCCGACGCGCTGATCGAACTCGGC
GCGCTGTCCGTGTCGGTGGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRLMGDKVTAKQTMIRTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
SGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADAHKNALWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGIDIVQEQIKIAAGEK
LAIRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIQ
RMRIALSEMVVEGIQTNIPLHRELMLDSKFVEGGTSIHYLEGRLAAKQQVAPEEA

Sequences:

>Translated_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRLMGDKVTAKQTMIRTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
SGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADAHKNALWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGIDIVQEQIKIAAGEK
LAIRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIQ
RMRIALSEMVVEGIQTNIPLHRELMLDSKFVEGGTSIHYLEGRLAAKQQVAPEEA
>Mature_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAQAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRLMGDKVTAKQTMIRTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
SGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADAHKNALWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGIDIVQEQIKIAAGEK
LAIRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIQ
RMRIALSEMVVEGIQTNIPLHRELMLDSKFVEGGTSIHYLEGRLAAKQQVAPEEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.9841986455982, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.9841986455982, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.9841986455982, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.7272727272727, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=43.7219730941704, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=43.7219730941704, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=43.7219730941704, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI38679971, Length=519, Percent_Identity=31.7919075144509, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679960, Length=519, Percent_Identity=31.7919075144509, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679977, Length=519, Percent_Identity=31.7919075144509, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679967, Length=519, Percent_Identity=31.7919075144509, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=519, Percent_Identity=31.7919075144509, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=31.5384615384615, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=66.815144766147, Blast_Score=605, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.1783295711061, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=45.3514739229025, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=42.9530201342282, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.6370967741936, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=28.5992217898833, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=28.5992217898833, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=40.4063205417607, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=459, Percent_Identity=44.6623093681917, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=459, Percent_Identity=45.0980392156863, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=32.8260869565217, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=523, Percent_Identity=29.8279158699809, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24651757, Length=433, Percent_Identity=45.9584295612009, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=44.8198198198198, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=44.8198198198198, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=44.8198198198198, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=44.8198198198198, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=44.8198198198198, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=44.8198198198198, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=44.8198198198198, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=44.8198198198198, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=44.8198198198198, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=44.8198198198198, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24651759, Length=396, Percent_Identity=44.9494949494949, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24586458, Length=513, Percent_Identity=29.6296296296296, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI161076407, Length=513, Percent_Identity=29.6296296296296, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24586460, Length=513, Percent_Identity=29.6296296296296, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI161076409, Length=513, Percent_Identity=29.6296296296296, Blast_Score=212, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50291; Mature: 50291

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCE
LNMPALISAAEVTDAQAIHPGYGFLSENADFAERVEQSGFTFIGPRPDTIRLMGDKVTAK
ECCCHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QTMIRTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKASGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHHHHHH
AVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADAHKNALWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGIDIVQEQIKIAAGEKLAIRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEEECEEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIQRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMLDSKFVEGGTSIHYLEGRLAAKQQVAPEEA
HHHHHHCCHHHCCCCEEEEECCHHHHHHCCCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCE
LNMPALISAAEVTDAQAIHPGYGFLSENADFAERVEQSGFTFIGPRPDTIRLMGDKVTAK
ECCCHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QTMIRTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKASGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHHHHHH
AVNMTREEAGRAFGNPQVYMEKYLENPRHIEIQVLADAHKNALWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGIDIVQEQIKIAAGEKLAIRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEEECEEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIQRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMLDSKFVEGGTSIHYLEGRLAAKQQVAPEEA
HHHHHHCCHHHCCCCEEEEECCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]