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The map label for this gene is hemB [H]

Identifier: 238025962

GI number: 238025962

Start: 301905

End: 302903

Strand: Reverse

Name: hemB [H]

Synonym: bglu_1g02880

Alternate gene names: 238025962

Gene position: 302903-301905 (Counterclockwise)

Preceding gene: 238025963

Following gene: 238025915

Centisome position: 7.75

GC content: 66.87

Gene sequence:

>999_bases
ATGAGCCTCCATCCCTTGCATCGCCCGCGCAGAATGCGCCGCGACGATTTCTCGCGTCGCCTGATGCGCGAAAACCTCCT
CACCACCAACGATCTGATCCTGCCCGTATTCGTGGTCGAAGGCACCAACGTGCGCCAGGGCGTGGCCTCGATGCCGGGCG
TCGAGCGCGTCTCGGTGGACCTGTTGATGGGCGTCGCCGAGCAGTGCGTCGAGCTCGGCGTGCCGGTACTGTCGCTGTTC
CCGGCGATCGAGCCGGCGCTGAAGACGCCCGACGGCCACGAGGCCGGCAACCCCGAGGGGCTGATTCCGCGTGCGGTGCG
TGAGCTCAAGCGCCGCTTCCCCGAGCTCGGCGTGCTGACCGACGTGGCGCTCGATCCGTACACGAGCCATGGCCAGGACG
GCGTGCTCGACGAACACGGCTACGTGATCAACGACGCGACCATCGAGATCCTGCTCGAGCAGGCGCGCGCGCAGGCCGAG
GCCGGCGTCGACATCGTCGCGCCGTCGGACATGATGGACGGCCGGATCGGCTCGATCCGCGAGATGCTGGAAAGCGACGG
CCATATCCACACGCGCATCATGGCGTACTCGGCGAAGTACGCATCGGCGTTCTACGGCCCGTTCCGCGACGCGGTCGGCT
CGGCCGCGAATCTCGGCAAGAGCAACAAGATGACGTACCAGATGGATCCGGCGAATTCCGACGAGGCGCTGCGCGAGATC
CGGCTCGACATCGACGAAGGCGCCGACATGGTGATGGTCAAGCCCGGCATGCCCTACCTCGACATCGTGCGCCGCGTGAA
GGACGAGTTCCGCTTTCCGACCTACGTCTACCAGGTCAGCGGCGAATACGCGATGCTGAAGGCCGCCGCGCTGAACGGCT
GGCTCGACCACGACAAGGTGGTGCTCGAATCCCTGCTCGCGTTCAAGCGCGCGGGCGCCGACGGCGTGCTCACCTACTTC
GCGCTCGAGGCCGCGCGCCTGCTGCGCGACCAGAAGTAA

Upstream 100 bases:

>100_bases
GCCTTGGCACGGCACTCGCTCGCTATCATATACCATTGTCTCGAAAATTCCCCGAAGGGTTCCGTAAGGGTTCCTTCAGA
CCGATTCCAGCGATTTCGTC

Downstream 100 bases:

>100_bases
GCCGGCGCGCCCGTGCGGGCATGCCAACGAAAACGGCGCAGCGCCTCAGGCGCCTCGCCGTTTTTTCATGGCGAATCCGT
CGGGGTTCAGGCCGAGGGCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSLHPLHRPRRMRRDDFSRRLMRENLLTTNDLILPVFVVEGTNVRQGVASMPGVERVSVDLLMGVAEQCVELGVPVLSLF
PAIEPALKTPDGHEAGNPEGLIPRAVRELKRRFPELGVLTDVALDPYTSHGQDGVLDEHGYVINDATIEILLEQARAQAE
AGVDIVAPSDMMDGRIGSIREMLESDGHIHTRIMAYSAKYASAFYGPFRDAVGSAANLGKSNKMTYQMDPANSDEALREI
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAALNGWLDHDKVVLESLLAFKRAGADGVLTYF
ALEAARLLRDQK

Sequences:

>Translated_332_residues
MSLHPLHRPRRMRRDDFSRRLMRENLLTTNDLILPVFVVEGTNVRQGVASMPGVERVSVDLLMGVAEQCVELGVPVLSLF
PAIEPALKTPDGHEAGNPEGLIPRAVRELKRRFPELGVLTDVALDPYTSHGQDGVLDEHGYVINDATIEILLEQARAQAE
AGVDIVAPSDMMDGRIGSIREMLESDGHIHTRIMAYSAKYASAFYGPFRDAVGSAANLGKSNKMTYQMDPANSDEALREI
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAALNGWLDHDKVVLESLLAFKRAGADGVLTYF
ALEAARLLRDQK
>Mature_331_residues
SLHPLHRPRRMRRDDFSRRLMRENLLTTNDLILPVFVVEGTNVRQGVASMPGVERVSVDLLMGVAEQCVELGVPVLSLFP
AIEPALKTPDGHEAGNPEGLIPRAVRELKRRFPELGVLTDVALDPYTSHGQDGVLDEHGYVINDATIEILLEQARAQAEA
GVDIVAPSDMMDGRIGSIREMLESDGHIHTRIMAYSAKYASAFYGPFRDAVGSAANLGKSNKMTYQMDPANSDEALREIR
LDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAALNGWLDHDKVVLESLLAFKRAGADGVLTYFA
LEAARLLRDQK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=43.3224755700326, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI87081728, Length=326, Percent_Identity=46.319018404908, Blast_Score=260, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6321398, Length=309, Percent_Identity=38.8349514563107, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=42.3728813559322, Blast_Score=227, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36839; Mature: 36708

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLHPLHRPRRMRRDDFSRRLMRENLLTTNDLILPVFVVEGTNVRQGVASMPGVERVSVD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCCHHHHHH
LLMGVAEQCVELGVPVLSLFPAIEPALKTPDGHEAGNPEGLIPRAVRELKRRFPELGVLT
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
DVALDPYTSHGQDGVLDEHGYVINDATIEILLEQARAQAEAGVDIVAPSDMMDGRIGSIR
HHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCHHHHH
EMLESDGHIHTRIMAYSAKYASAFYGPFRDAVGSAANLGKSNKMTYQMDPANSDEALREI
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAALNGWLDHDKV
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHH
VLESLLAFKRAGADGVLTYFALEAARLLRDQK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLHPLHRPRRMRRDDFSRRLMRENLLTTNDLILPVFVVEGTNVRQGVASMPGVERVSVD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCCHHHHHH
LLMGVAEQCVELGVPVLSLFPAIEPALKTPDGHEAGNPEGLIPRAVRELKRRFPELGVLT
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
DVALDPYTSHGQDGVLDEHGYVINDATIEILLEQARAQAEAGVDIVAPSDMMDGRIGSIR
HHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCHHHHH
EMLESDGHIHTRIMAYSAKYASAFYGPFRDAVGSAANLGKSNKMTYQMDPANSDEALREI
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAALNGWLDHDKV
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHH
VLESLLAFKRAGADGVLTYFALEAARLLRDQK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]