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The map label for this gene is degS [H]

Identifier: 238025566

GI number: 238025566

Start: 2806559

End: 2807956

Strand: Direct

Name: degS [H]

Synonym: bglu_2g22630

Alternate gene names: 238025566

Gene position: 2806559-2807956 (Clockwise)

Preceding gene: 238025564

Following gene: 238025567

Centisome position: 99.27

GC content: 70.74

Gene sequence:

>1398_bases
ATGAAACTCAAGGCGAAGATATTCCTGCTCGCGATCGTGCCGTTCCTGGCTGCGATCGCGGGCATCGGCTTCGGCGTGCG
TCAGCAGGCCACCGCACTGGCGCGCGCGCAGCACGAGACGATCGAGGCCGCCTACCTGTCGAGCAAGGAGCTCGAGCTCA
AGCATTACGTCGAACTCGCCACCAGCGCCATCGCGCCGCTCTACGAAGCCTCGCGCGACGGCGCGCCCGGCAACGACGCG
CGCCGCGCCCAGGCGCTCGAGATCCTGCGCAAGATGGACTTCGGCCCCGACGGCTATTTCTTCGTCTACGACATGCAGGG
CGACTCACTGATGCACCCGCGCGAGCCGGAGCGCGTGGGCCGCAACTTCTGGGCGATGCGCGACCCGCAGGGCGCGCCCA
CCATGCAGCATCTGCTCGCCGCCGCCTCGCACGGCCAGGGCTACGTCCGCTATCTGTGGCAACGGCCCACCACCGGCAAG
GTCGAGCCGAAGCTCGGCTACGTGGTCGGGCTCGACCGCTGGGGCTGGATGCTCGGCACCGGCATCTACCTCGACGACGT
CGATCGCGCGCTCGCGCGCATCGACGCGCGCGCCTCGGCCGAAATCGACAGCACCATGAAGGGCCTCGCTGCGATCGCAC
TGGCCGGCGCCGCGGCGATCGCGCTCTGCGCGCTGGTGCTCAACGTCAGCGAATCGCGGCACGCCGATGCGCGCCTGAAG
GCGCTCGCGCAGCGCGTGGTGGAATCGCAGGAAGACGAGCGCGCGCGCCTGTCGCGCGAGCTGCACGACGGCATCAGCCA
GATGATGGTATCGGTGAAATTGATGCTCGAATCGGCACTCGAGCGCTTCGAGCGCAGCCCGGCTCGCGACGCGGCCGCCG
AGGGCGTGCTCGCCAAGAGCGTCGCGCGGCTCGGCGACGTGCTGCGCGAGGTGCGCCGCATCTCGCATGCGCTGCGCCCC
GCGATGCTCGACGATCTCGGGCTGGCCGCCGCGCTCGACCAGCTGGTCCGCGAGCTGGGCAGCGAGACCGGCGTGGAGCT
CGGCTACACGCAGATCGTGCACTCGGGCTCGCGGCCGCTGCCGGCCGCCGTCAACACCGCGCTGTTCCGGATCGCGCAGG
AAGCCCTGACCAACCTGGTCCGCCATGCGCAGGCCACGCGCGGCGCGGTCTCGCTGGAGATCGCCGCGCACTCGGTGGCG
CTGGCCGTCGCCGACAACGGCTGCGGCTTCGACGTCGAGCGCATTCAGGCCGATCCGCACGGCGGCGTGGGCCTGCGCAA
CATGCGCGAACGGATCGACGCGATCGGCGGCACGCTGGCGATCCGCTCGCAGCCAGGCCATACCGTCGTTTCCGTGCGCG
TGCCGCTGCCCGCCACCCAGACAGGAGCCCGACGATGA

Upstream 100 bases:

>100_bases
GTGCGTCGCGGCGGCCGGAAATCGCCGACAATAGCGGACCCTGGCGCTCCGGCGCGCGTCGCGCGGCGGGTGCGCCGCCG
CGTGTTTGCGTCGATCGACC

Downstream 100 bases:

>100_bases
CCCTTGCCTCTCCCGGCGCCAGTCCGCCGCCCCGACAGCCGGCCCAGCCCGGACCGTGCGCCCGCCTGCTGCTGGTGGAC
GACCACCCGCTGGTGCGCGA

Product: Sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKLKAKIFLLAIVPFLAAIAGIGFGVRQQATALARAQHETIEAAYLSSKELELKHYVELATSAIAPLYEASRDGAPGNDA
RRAQALEILRKMDFGPDGYFFVYDMQGDSLMHPREPERVGRNFWAMRDPQGAPTMQHLLAAASHGQGYVRYLWQRPTTGK
VEPKLGYVVGLDRWGWMLGTGIYLDDVDRALARIDARASAEIDSTMKGLAAIALAGAAAIALCALVLNVSESRHADARLK
ALAQRVVESQEDERARLSRELHDGISQMMVSVKLMLESALERFERSPARDAAAEGVLAKSVARLGDVLREVRRISHALRP
AMLDDLGLAAALDQLVRELGSETGVELGYTQIVHSGSRPLPAAVNTALFRIAQEALTNLVRHAQATRGAVSLEIAAHSVA
LAVADNGCGFDVERIQADPHGGVGLRNMRERIDAIGGTLAIRSQPGHTVVSVRVPLPATQTGARR

Sequences:

>Translated_465_residues
MKLKAKIFLLAIVPFLAAIAGIGFGVRQQATALARAQHETIEAAYLSSKELELKHYVELATSAIAPLYEASRDGAPGNDA
RRAQALEILRKMDFGPDGYFFVYDMQGDSLMHPREPERVGRNFWAMRDPQGAPTMQHLLAAASHGQGYVRYLWQRPTTGK
VEPKLGYVVGLDRWGWMLGTGIYLDDVDRALARIDARASAEIDSTMKGLAAIALAGAAAIALCALVLNVSESRHADARLK
ALAQRVVESQEDERARLSRELHDGISQMMVSVKLMLESALERFERSPARDAAAEGVLAKSVARLGDVLREVRRISHALRP
AMLDDLGLAAALDQLVRELGSETGVELGYTQIVHSGSRPLPAAVNTALFRIAQEALTNLVRHAQATRGAVSLEIAAHSVA
LAVADNGCGFDVERIQADPHGGVGLRNMRERIDAIGGTLAIRSQPGHTVVSVRVPLPATQTGARR
>Mature_465_residues
MKLKAKIFLLAIVPFLAAIAGIGFGVRQQATALARAQHETIEAAYLSSKELELKHYVELATSAIAPLYEASRDGAPGNDA
RRAQALEILRKMDFGPDGYFFVYDMQGDSLMHPREPERVGRNFWAMRDPQGAPTMQHLLAAASHGQGYVRYLWQRPTTGK
VEPKLGYVVGLDRWGWMLGTGIYLDDVDRALARIDARASAEIDSTMKGLAAIALAGAAAIALCALVLNVSESRHADARLK
ALAQRVVESQEDERARLSRELHDGISQMMVSVKLMLESALERFERSPARDAAAEGVLAKSVARLGDVLREVRRISHALRP
AMLDDLGLAAALDQLVRELGSETGVELGYTQIVHSGSRPLPAAVNTALFRIAQEALTNLVRHAQATRGAVSLEIAAHSVA
LAVADNGCGFDVERIQADPHGGVGLRNMRERIDAIGGTLAIRSQPGHTVVSVRVPLPATQTGARR

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=33.0097087378641, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082311, Length=227, Percent_Identity=35.2422907488987, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787474, Length=208, Percent_Identity=28.8461538461538, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50286; Mature: 50286

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKAKIFLLAIVPFLAAIAGIGFGVRQQATALARAQHETIEAAYLSSKELELKHYVELA
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TSAIAPLYEASRDGAPGNDARRAQALEILRKMDFGPDGYFFVYDMQGDSLMHPREPERVG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHC
RNFWAMRDPQGAPTMQHLLAAASHGQGYVRYLWQRPTTGKVEPKLGYVVGLDRWGWMLGT
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHCC
GIYLDDVDRALARIDARASAEIDSTMKGLAAIALAGAAAIALCALVLNVSESRHADARLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALAQRVVESQEDERARLSRELHDGISQMMVSVKLMLESALERFERSPARDAAAEGVLAKS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VARLGDVLREVRRISHALRPAMLDDLGLAAALDQLVRELGSETGVELGYTQIVHSGSRPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCC
PAAVNTALFRIAQEALTNLVRHAQATRGAVSLEIAAHSVALAVADNGCGFDVERIQADPH
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHEEEEEEECCCCCCCHHHHCCCCC
GGVGLRNMRERIDAIGGTLAIRSQPGHTVVSVRVPLPATQTGARR
CCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKLKAKIFLLAIVPFLAAIAGIGFGVRQQATALARAQHETIEAAYLSSKELELKHYVELA
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TSAIAPLYEASRDGAPGNDARRAQALEILRKMDFGPDGYFFVYDMQGDSLMHPREPERVG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHC
RNFWAMRDPQGAPTMQHLLAAASHGQGYVRYLWQRPTTGKVEPKLGYVVGLDRWGWMLGT
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHCC
GIYLDDVDRALARIDARASAEIDSTMKGLAAIALAGAAAIALCALVLNVSESRHADARLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALAQRVVESQEDERARLSRELHDGISQMMVSVKLMLESALERFERSPARDAAAEGVLAKS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VARLGDVLREVRRISHALRPAMLDDLGLAAALDQLVRELGSETGVELGYTQIVHSGSRPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCC
PAAVNTALFRIAQEALTNLVRHAQATRGAVSLEIAAHSVALAVADNGCGFDVERIQADPH
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHEEEEEEECCCCCCCHHHHCCCCC
GGVGLRNMRERIDAIGGTLAIRSQPGHTVVSVRVPLPATQTGARR
CCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]