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The map label for this gene is hsaA [H]

Identifier: 238024335

GI number: 238024335

Start: 1143056

End: 1144339

Strand: Direct

Name: hsaA [H]

Synonym: bglu_2g09230

Alternate gene names: 238024335

Gene position: 1143056-1144339 (Clockwise)

Preceding gene: 238024334

Following gene: 238024336

Centisome position: 40.43

GC content: 65.42

Gene sequence:

>1284_bases
TTGAGCACGATACAGAACTCGCAGTGCACGACTCGTGAAATGACAGATGAACGCATCTTGCAGGAAGGGAATTCGGCTGG
ACATGACGCCATTGTGCTCGATGAATCGGTGGTCGAGCATGAGGCATTGATCGCGAAGGCGGCAGAAGTCGCCAGCGTGC
TCGCGGAAGAATCGCGCGCTGCCGATGCCGGGCGCCGCCTGACCGAGCGTGCCGTCACCGCGCTGACCGATGCCGGGCTG
ATGCGGCTTTTCACGCCGCGCCGGCTCGGCGGTTACGAAGCGGGTCCCGCCACGCTGTTCGACGTCTGCTACGAACTGGG
GCGCGGTTGCTGCTCGGCGGCGTGGGTCACGAGCGTGCTCAACATGGGCAACTACATGATCGCCCACTTCCCCGAGAGGA
CGCAGGACGACGTGTGGGGCGGCAACCGCGACACGCGCACCGCGCTCATCATTGCGCCTTCGCGCGCCCAGGTCGAACGC
GTCGACGGCGGTGTGGTGGTGACGGGAGAGTGGGCTTATGCATCGGGCAGCCTGCATGCCGAATGGATCGGCGCGCTGAT
CCCGAAAGGCGTCGATGCCGACGACGAGACGATCAACTTGGTCCTCATGCCGATGAACGAGCTCGAAGTCCGCGACTCCT
GGCATATCACGGGCATGCGCGGCACCGGCAGCAACACGGTCGTGGCGAACCGGCTGTTCATTCCGCGCCATCGCGTGACG
CCTTACGCGCCCATCGTGCAGGGCCGGTCGCGCCTGCCGTCGGAACGGCACCGTTTATATAGCGGCGCGTTCTCGGGCTT
GCTGTCGATCGGTCTGCTCGGACCGCAACTCGGGGCGCTCGTCACCGCGCTGGAACTCGTGCGCGATCAGGCCCACGAGC
GCCGTGTCGCCTCGTCCACGTTCAAGAGCCAGGCTGTTTCGCCGGCGTTCCAGACCGATCTCGCCGAAGCTTCGATGATG
ATCGACGGCGCGCAGCTGCACGCCCGCCGCATCGTCGAAACGGTCGAGCACCACGCACTGGCCGGCGTCCTGCCCGACGA
AGTGACGCGTTCGCGTTTTCGGATGGAATCGACGCGCGTCACGCGCCTGTGCCGCGAGGCCATCGATCGCCTCATGACGG
CCTACGGCAGCGCCGCCTTCATGGAATCCAATCCGCTGCAGTTGATCTGGCGCGATCTGAACGTGGCGAGCCGCCACGCG
GGCTTCGGGATGGGCATTCCGCAACTTGTCTACGGCCGCGCGCTCGTCGGCCTCGATCCGCGCGAAATCAGCTACCTCGT
TTAA

Upstream 100 bases:

>100_bases
TTGCTTCGATTTCCTGGTTGATTGATGGTCAAATTTCTCACAAACATTATTGTTTTGAATTTTTAAACAATAAAGATTGT
AAGTTTCTTCTGGAGACGCC

Downstream 100 bases:

>100_bases
TCCCACGCGGCCTCCCGGCGGGTGGCCCTCTTTGACTTCAGGAGCTTGCATGTCAGACGTCGAATCCCTCGAAAACCGAC
CGGAAAATCACGCGCACGCC

Product: acyl-CoA dehydrogenase-like protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSTIQNSQCTTREMTDERILQEGNSAGHDAIVLDESVVEHEALIAKAAEVASVLAEESRAADAGRRLTERAVTALTDAGL
MRLFTPRRLGGYEAGPATLFDVCYELGRGCCSAAWVTSVLNMGNYMIAHFPERTQDDVWGGNRDTRTALIIAPSRAQVER
VDGGVVVTGEWAYASGSLHAEWIGALIPKGVDADDETINLVLMPMNELEVRDSWHITGMRGTGSNTVVANRLFIPRHRVT
PYAPIVQGRSRLPSERHRLYSGAFSGLLSIGLLGPQLGALVTALELVRDQAHERRVASSTFKSQAVSPAFQTDLAEASMM
IDGAQLHARRIVETVEHHALAGVLPDEVTRSRFRMESTRVTRLCREAIDRLMTAYGSAAFMESNPLQLIWRDLNVASRHA
GFGMGIPQLVYGRALVGLDPREISYLV

Sequences:

>Translated_427_residues
MSTIQNSQCTTREMTDERILQEGNSAGHDAIVLDESVVEHEALIAKAAEVASVLAEESRAADAGRRLTERAVTALTDAGL
MRLFTPRRLGGYEAGPATLFDVCYELGRGCCSAAWVTSVLNMGNYMIAHFPERTQDDVWGGNRDTRTALIIAPSRAQVER
VDGGVVVTGEWAYASGSLHAEWIGALIPKGVDADDETINLVLMPMNELEVRDSWHITGMRGTGSNTVVANRLFIPRHRVT
PYAPIVQGRSRLPSERHRLYSGAFSGLLSIGLLGPQLGALVTALELVRDQAHERRVASSTFKSQAVSPAFQTDLAEASMM
IDGAQLHARRIVETVEHHALAGVLPDEVTRSRFRMESTRVTRLCREAIDRLMTAYGSAAFMESNPLQLIWRDLNVASRHA
GFGMGIPQLVYGRALVGLDPREISYLV
>Mature_426_residues
STIQNSQCTTREMTDERILQEGNSAGHDAIVLDESVVEHEALIAKAAEVASVLAEESRAADAGRRLTERAVTALTDAGLM
RLFTPRRLGGYEAGPATLFDVCYELGRGCCSAAWVTSVLNMGNYMIAHFPERTQDDVWGGNRDTRTALIIAPSRAQVERV
DGGVVVTGEWAYASGSLHAEWIGALIPKGVDADDETINLVLMPMNELEVRDSWHITGMRGTGSNTVVANRLFIPRHRVTP
YAPIVQGRSRLPSERHRLYSGAFSGLLSIGLLGPQLGALVTALELVRDQAHERRVASSTFKSQAVSPAFQTDLAEASMMI
DGAQLHARRIVETVEHHALAGVLPDEVTRSRFRMESTRVTRLCREAIDRLMTAYGSAAFMESNPLQLIWRDLNVASRHAG
FGMGIPQLVYGRALVGLDPREISYLV

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 46692; Mature: 46561

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIQNSQCTTREMTDERILQEGNSAGHDAIVLDESVVEHEALIAKAAEVASVLAEESRA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAGRRLTERAVTALTDAGLMRLFTPRRLGGYEAGPATLFDVCYELGRGCCSAAWVTSVL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
NMGNYMIAHFPERTQDDVWGGNRDTRTALIIAPSRAQVERVDGGVVVTGEWAYASGSLHA
HCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEECCEECCCCCHH
EWIGALIPKGVDADDETINLVLMPMNELEVRDSWHITGMRGTGSNTVVANRLFIPRHRVT
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCC
PYAPIVQGRSRLPSERHRLYSGAFSGLLSIGLLGPQLGALVTALELVRDQAHERRVASST
CCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSQAVSPAFQTDLAEASMMIDGAQLHARRIVETVEHHALAGVLPDEVTRSRFRMESTRV
HHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TRLCREAIDRLMTAYGSAAFMESNPLQLIWRDLNVASRHAGFGMGIPQLVYGRALVGLDP
HHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHCCCCH
REISYLV
HHHCCCC
>Mature Secondary Structure 
STIQNSQCTTREMTDERILQEGNSAGHDAIVLDESVVEHEALIAKAAEVASVLAEESRA
CCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAGRRLTERAVTALTDAGLMRLFTPRRLGGYEAGPATLFDVCYELGRGCCSAAWVTSVL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
NMGNYMIAHFPERTQDDVWGGNRDTRTALIIAPSRAQVERVDGGVVVTGEWAYASGSLHA
HCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEECCEECCCCCHH
EWIGALIPKGVDADDETINLVLMPMNELEVRDSWHITGMRGTGSNTVVANRLFIPRHRVT
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCC
PYAPIVQGRSRLPSERHRLYSGAFSGLLSIGLLGPQLGALVTALELVRDQAHERRVASST
CCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSQAVSPAFQTDLAEASMMIDGAQLHARRIVETVEHHALAGVLPDEVTRSRFRMESTRV
HHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TRLCREAIDRLMTAYGSAAFMESNPLQLIWRDLNVASRHAGFGMGIPQLVYGRALVGLDP
HHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHCCCCH
REISYLV
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]