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The map label for this gene is selB [H]

Identifier: 238024286

GI number: 238024286

Start: 1055286

End: 1057196

Strand: Direct

Name: selB [H]

Synonym: bglu_2g08690

Alternate gene names: 238024286

Gene position: 1055286-1057196 (Clockwise)

Preceding gene: 238024285

Following gene: 238024288

Centisome position: 37.32

GC content: 73.94

Gene sequence:

>1911_bases
ATGATCGTCGGCACCGCGGGCCACATCGATCACGGCAAGACCACGCTGGTGCGCGCGCTGACCGGCGTGGACACCGACCG
GCTGAAGGAGGAGAAGGCGCGCGGCATCTCGATCGAGCTCGGTTACGCCTACACGCCGCTCGACAACGGCGAGGTGCTCG
GCATGATCGACGTGCCCGGCCACGAGCGGCTCGTTCATACCATGGCCGCCGGCGCCTGCGGGATCGACGTCGCGCTGCTC
GTGATCGCCGCCGACGACGGCGTGATGCCGCAAACGCGCGAGCATCTCGCGATCCTCCAACTGCTGGGCGTCACGCATGG
CCTGGTCGCGCTGACCAAATGCGATCGCGTGGATGCCGCGCGCGTCGCGCACGCGCGCGACGAGATTCGCGCCGAGCTGG
CGGGCACCGCGCTGGCCGCGGCGCCGATCTTCGAGACCTGTGCCACGCGGGCCGGCGATGCCGGCGTGGCCGCGCTCGGC
GCCGCGCTGCGCGCGCTGGCCGCGCAATGGCGCGCGCGGCGCGACGACGGGCTGTTCCGGCTCGCCGTGGACCGCGTATT
CACGCTGAGCGGGCAGGGGACCGTGGTGACCGGGACCGCGCTCGCCGGGCGCGTGCGTGCCGGCGAGACGCTGACGGTCG
TGCGCTCGGGCGAGGTCGTGCGCGTGCGCGGGCTGCACGCGCAGAACCGTGCCGCCGAGCTTGGCCGTGCCGGCGAGCGC
TGTGCGCTGAACCTGGCCGGCATCGACAAGGCCGCGCTCGCGCGCGGCGACGTGGTGGCCGACGCGCGTCTGGCGAGCGT
GTCGCCGCGCATCGACGTCGAGCTGAGCTTGCTGGCCGAGGCGAGCCTCACGCTCAGGCACTGGGCGCCGCTGCACGTGC
ATCTCGGCACGCAGCATCAGGTGGCGCACGTCGTGCCGATCGACGTCGACGCGCTCGCGGCCGGACAGCGCGGCCGCGTG
CAGCTGGTGTTCGATGCGCCCGTGTTCGCGATGCCCGGCGACCGCTTCATCGTGCGCAACGCGCAGGCTACGCGCACCGT
GGGCGGGGGGCGCGTGCTCGATCCGTTCGGTCCCGCGCACAAGCGCCGGACCCTCGCGCGCCGCGCTTGGCTCGACGCGC
TGGCCGTGTGGCTCGATGCGGGGCAACTGGGGCCGCTGCTCGACGAGGCGCCGCTTGGCGTGCCGGTCGCCACGCTGGTG
CATCTGACCGGGCTGGCCGCCGAGGCGCTGCCGCTGCCCGAGAACGCGGCGGTGATGCCCGGCGCGGGCGGGCCGCGCGC
GATCGCGCCGCGTTATCGCGAGGCGCTGCGCCGGCGCGTGCTGGAGGCGCTGGCCGTGTTCCATGCGCGCACGCCCGACG
AGCCGGGGCCGGAGCTCGGGCGGCTGCGTCGCATCGCGCTGCCGCTCGCCGACGAGCCGCTGTGGCGGGCGCTGATCGAC
GCGATGGCTGGTGAAGGCAGCGTGGTGCGGCAGGGGCAGTGGGTCCACCTGCCGACTCATACGGCAAGCCTCGAGCCCGC
CGACGAGGCGCTCGCGCAGCGCCTGCTGCCGTTGCTGGCGGCGGGGCGCTTCGAGGCGCCGTGGGTACGCGATCTGGCGG
CGGCGACGGGTGCCGGCGAGGAGGCGGTACGCACGCTGCTGCGCAAGCTCGCGCGGCGCGGCGAGGTGCATCAGGTGGTG
CGCGACCTGTTCTATGGACGCGAGGCGGTGGCCGAACTCGCGCGGATCATCGCCGCGCTGGCGGCGCAAGGCGGCGGCTC
GGTGGACGCGGCGACCTTTCGCGACGCGACCGGCCTGGGCCGCAAGCGCGCGATCCAGATTCTCGAATTCTTCGACCGGG
TTGGGTATACTCGTTTTCATCGCGACCGCCACCTGTTGCGCGCGGAAAGCGCACTACGCGATCTCGCGTAG

Upstream 100 bases:

>100_bases
TCGACCTGCGCTGCCTCGAGGCCGCCGACGAGGCCGCGCTGATCGCGCAGTGCATGGCCGCTGGTGCCGCGGCGCTGGGC
GAGCCGGGAGGCGCGCGCGC

Downstream 100 bases:

>100_bases
CGGCGGTGGTGGCGCGCGGCACGCTCGCGGAAGGCATTCGTATCCGGTGGTGCGGCCAGGCTTCAAACCTGGTTGGGGAC
GTCAATCGTTCCCGGGTTGG

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLDNGEVLGMIDVPGHERLVHTMAAGACGIDVALL
VIAADDGVMPQTREHLAILQLLGVTHGLVALTKCDRVDAARVAHARDEIRAELAGTALAAAPIFETCATRAGDAGVAALG
AALRALAAQWRARRDDGLFRLAVDRVFTLSGQGTVVTGTALAGRVRAGETLTVVRSGEVVRVRGLHAQNRAAELGRAGER
CALNLAGIDKAALARGDVVADARLASVSPRIDVELSLLAEASLTLRHWAPLHVHLGTQHQVAHVVPIDVDALAAGQRGRV
QLVFDAPVFAMPGDRFIVRNAQATRTVGGGRVLDPFGPAHKRRTLARRAWLDALAVWLDAGQLGPLLDEAPLGVPVATLV
HLTGLAAEALPLPENAAVMPGAGGPRAIAPRYREALRRRVLEALAVFHARTPDEPGPELGRLRRIALPLADEPLWRALID
AMAGEGSVVRQGQWVHLPTHTASLEPADEALAQRLLPLLAAGRFEAPWVRDLAAATGAGEEAVRTLLRKLARRGEVHQVV
RDLFYGREAVAELARIIAALAAQGGGSVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDRHLLRAESALRDLA

Sequences:

>Translated_636_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLDNGEVLGMIDVPGHERLVHTMAAGACGIDVALL
VIAADDGVMPQTREHLAILQLLGVTHGLVALTKCDRVDAARVAHARDEIRAELAGTALAAAPIFETCATRAGDAGVAALG
AALRALAAQWRARRDDGLFRLAVDRVFTLSGQGTVVTGTALAGRVRAGETLTVVRSGEVVRVRGLHAQNRAAELGRAGER
CALNLAGIDKAALARGDVVADARLASVSPRIDVELSLLAEASLTLRHWAPLHVHLGTQHQVAHVVPIDVDALAAGQRGRV
QLVFDAPVFAMPGDRFIVRNAQATRTVGGGRVLDPFGPAHKRRTLARRAWLDALAVWLDAGQLGPLLDEAPLGVPVATLV
HLTGLAAEALPLPENAAVMPGAGGPRAIAPRYREALRRRVLEALAVFHARTPDEPGPELGRLRRIALPLADEPLWRALID
AMAGEGSVVRQGQWVHLPTHTASLEPADEALAQRLLPLLAAGRFEAPWVRDLAAATGAGEEAVRTLLRKLARRGEVHQVV
RDLFYGREAVAELARIIAALAAQGGGSVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDRHLLRAESALRDLA
>Mature_636_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLDNGEVLGMIDVPGHERLVHTMAAGACGIDVALL
VIAADDGVMPQTREHLAILQLLGVTHGLVALTKCDRVDAARVAHARDEIRAELAGTALAAAPIFETCATRAGDAGVAALG
AALRALAAQWRARRDDGLFRLAVDRVFTLSGQGTVVTGTALAGRVRAGETLTVVRSGEVVRVRGLHAQNRAAELGRAGER
CALNLAGIDKAALARGDVVADARLASVSPRIDVELSLLAEASLTLRHWAPLHVHLGTQHQVAHVVPIDVDALAAGQRGRV
QLVFDAPVFAMPGDRFIVRNAQATRTVGGGRVLDPFGPAHKRRTLARRAWLDALAVWLDAGQLGPLLDEAPLGVPVATLV
HLTGLAAEALPLPENAAVMPGAGGPRAIAPRYREALRRRVLEALAVFHARTPDEPGPELGRLRRIALPLADEPLWRALID
AMAGEGSVVRQGQWVHLPTHTASLEPADEALAQRLLPLLAAGRFEAPWVRDLAAATGAGEEAVRTLLRKLARRGEVHQVV
RDLFYGREAVAELARIIAALAAQGGGSVDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDRHLLRAESALRDLA

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=405, Percent_Identity=28.1481481481481, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI54607086, Length=307, Percent_Identity=27.6872964169381, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI53729339, Length=226, Percent_Identity=30.5309734513274, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI53729337, Length=226, Percent_Identity=30.5309734513274, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI2367247, Length=631, Percent_Identity=42.6307448494453, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1790412, Length=391, Percent_Identity=30.690537084399, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI1789737, Length=391, Percent_Identity=30.690537084399, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1789108, Length=369, Percent_Identity=28.4552845528455, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789559, Length=93, Percent_Identity=39.7849462365591, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=396, Percent_Identity=29.7979797979798, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25141371, Length=383, Percent_Identity=29.7650130548303, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17506081, Length=260, Percent_Identity=27.3076923076923, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17565438, Length=329, Percent_Identity=22.7963525835866, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115532065, Length=319, Percent_Identity=26.0188087774295, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532067, Length=319, Percent_Identity=24.7648902821317, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=118, Percent_Identity=35.5932203389831, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=304, Percent_Identity=31.5789473684211, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281363316, Length=388, Percent_Identity=27.8350515463918, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17864358, Length=388, Percent_Identity=27.8350515463918, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19921738, Length=379, Percent_Identity=28.4960422163588, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922690, Length=320, Percent_Identity=29.0625, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24647046, Length=259, Percent_Identity=29.3436293436293, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647048, Length=259, Percent_Identity=29.3436293436293, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137380, Length=350, Percent_Identity=26, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28572034, Length=118, Percent_Identity=40.6779661016949, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 67699; Mature: 67699

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLDNGEVLGMIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HERLVHTMAAGACGIDVALLVIAADDGVMPQTREHLAILQLLGVTHGLVALTKCDRVDAA
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RVAHARDEIRAELAGTALAAAPIFETCATRAGDAGVAALGAALRALAAQWRARRDDGLFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
LAVDRVFTLSGQGTVVTGTALAGRVRAGETLTVVRSGEVVRVRGLHAQNRAAELGRAGER
EEEHHEEEECCCCEEEECHHHHCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHCCCCCC
CALNLAGIDKAALARGDVVADARLASVSPRIDVELSLLAEASLTLRHWAPLHVHLGTQHQ
EEEEECCCCHHHHHCCCEEECCHHHCCCCCCCEEEEEHHHHHHHHEECCEEEEEECCCCC
VAHVVPIDVDALAAGQRGRVQLVFDAPVFAMPGDRFIVRNAQATRTVGGGRVLDPFGPAH
EEEEEECCHHHHCCCCCCCEEEEECCCEEECCCCEEEEECCCHHEECCCCEEECCCCCHH
KRRTLARRAWLDALAVWLDAGQLGPLLDEAPLGVPVATLVHLTGLAAEALPLPENAAVMP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECC
GAGGPRAIAPRYREALRRRVLEALAVFHARTPDEPGPELGRLRRIALPLADEPLWRALID
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
AMAGEGSVVRQGQWVHLPTHTASLEPADEALAQRLLPLLAAGRFEAPWVRDLAAATGAGE
HHCCCCCEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
EAVRTLLRKLARRGEVHQVVRDLFYGREAVAELARIIAALAAQGGGSVDAATFRDATGLG
HHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
RKRAIQILEFFDRVGYTRFHRDRHLLRAESALRDLA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLDNGEVLGMIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HERLVHTMAAGACGIDVALLVIAADDGVMPQTREHLAILQLLGVTHGLVALTKCDRVDAA
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RVAHARDEIRAELAGTALAAAPIFETCATRAGDAGVAALGAALRALAAQWRARRDDGLFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
LAVDRVFTLSGQGTVVTGTALAGRVRAGETLTVVRSGEVVRVRGLHAQNRAAELGRAGER
EEEHHEEEECCCCEEEECHHHHCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHCCCCCC
CALNLAGIDKAALARGDVVADARLASVSPRIDVELSLLAEASLTLRHWAPLHVHLGTQHQ
EEEEECCCCHHHHHCCCEEECCHHHCCCCCCCEEEEEHHHHHHHHEECCEEEEEECCCCC
VAHVVPIDVDALAAGQRGRVQLVFDAPVFAMPGDRFIVRNAQATRTVGGGRVLDPFGPAH
EEEEEECCHHHHCCCCCCCEEEEECCCEEECCCCEEEEECCCHHEECCCCEEECCCCCHH
KRRTLARRAWLDALAVWLDAGQLGPLLDEAPLGVPVATLVHLTGLAAEALPLPENAAVMP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECC
GAGGPRAIAPRYREALRRRVLEALAVFHARTPDEPGPELGRLRRIALPLADEPLWRALID
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
AMAGEGSVVRQGQWVHLPTHTASLEPADEALAQRLLPLLAAGRFEAPWVRDLAAATGAGE
HHCCCCCEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
EAVRTLLRKLARRGEVHQVVRDLFYGREAVAELARIIAALAAQGGGSVDAATFRDATGLG
HHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
RKRAIQILEFFDRVGYTRFHRDRHLLRAESALRDLA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]