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The map label for this gene is folC [H]

Identifier: 238024263

GI number: 238024263

Start: 1024935

End: 1026245

Strand: Direct

Name: folC [H]

Synonym: bglu_2g08460

Alternate gene names: 238024263

Gene position: 1024935-1026245 (Clockwise)

Preceding gene: 238024262

Following gene: 238024264

Centisome position: 36.25

GC content: 68.04

Gene sequence:

>1311_bases
ATGAGCACATTTCCCACTCTCGATGCCTGGCTTTCGCACCTCGAAACCGCGCATCCGGTCGGCATCGACATGGGCCTCGC
CCGCGTCACCAAGGTCAAGGAGGCGCTCGGGCTCGAGTTCGCCTGCCCGGTCATCACGGTGGGCGGCACCAACGGCAAGG
GCTCGACCTGCGCGTTGCTCGAGACGATCCTGCTGAAGGCTGGCTATCGCGTCGGCTGCCATACCTCGCCGCACCTGCTG
GCGTTCAACGAGCGCGCGCGGATCGGCGGCGCGAACGTCGACGACGCGGCGCTGCTGCCGCATTTCGAGGCGGTGGAGGC
GGCCCGCCTGAGCCTGGCCGAGCCGGTCACGCTGACCTATTTCGAATTCACGACGCTGGTGATCCTGCGCCTGTTCGCGG
CCAGCCAACTCGACGCGGTGATCCTCGAGGTGGGGCTGGGCGGGCGGCTCGACGCGATGAACATGCTCGACGCCGACTGC
GCGGTCGTCACCAGCATCGACATCGACCACACCGAATACCTCGGCGACACGCGCGAGCAGATCGGCTTCGAGAAGGCCGG
CATCTTCCGCCCCGGCAAGCCGGCCGTGTGCGGCGATCCCGCGCCGCCGCAGACGCTGATCGATCACGCGAACGCGATCG
GCGCGGACCTCTGGCTGGTCGGACGCGACTTCCGCTACGAGACGCAGCCCGGCAACGAGCGCCAGCAGTGGAGCTACCTG
GGCCGCGACAAGCGCTATCCGGCGCTCGCCTATCCGGCGCTGCGCGGCGCGAACCAGCTGATCAACGCGTCGGCCGCGCT
GGCCGCGCTCGAATCGCTGCGCGCCCGGCTGCCGGTGTCGGCCCAGGACATCCGGCTCGGCCTTGCCAACGTCGAGCTGC
CCGGGCGCTTCCAGGTGCTGCCCGGCAAGCCCGCGATCGTGCTCGATGTCGCGCACAACCCGCACGCGTCGGCGGTGCTC
GCGCAAAATCTCGGCAACATGGGCTTCTTTCCGTACACTTACGCGGTGTTCGGCGCGATGCGCGACAAGGACATCGCGGG
CGTGCTGCGGCAGCTGAAGGGCGAGATCGATCACTGGTGCGTGACCGATCTGCCGCTGCCGCGCGCCGCTTCGGCCGAGA
CGCTCGAGGCCGCCTTGCGCGAGGCCGGCGTCGAGGACGGCCCCGACAGCAGCGTGACGCGCTACGCGTCGCCTGCCGAG
GCATTTCGAGATACGCTGAAGCGGGCCTCGGAGAATGATAGAATCGTGGTCTTTGGTAGCTTTTATACGGTAGCCGGCGT
GATGGCCTATCGTAAATCGCAGCAACACTGA

Upstream 100 bases:

>100_bases
GCGCGGCATCCGCCGACGCGTCGTCCGGCCCGGCCGGGCGGCGCGTTTTCGTTTTTCCGGGCAGGCCCGTGCGCGGGCCT
GCCGCTTCGCAGTGGTACAG

Downstream 100 bases:

>100_bases
CGGGCAGTCCGGATCAGCCATACATGGGAATCTTCTCGTTCGGCAAGAAGAAAGACGACGACGCGCCGCCCCGGCGCGGG
TCACGGTCCGGGTCTCGCCC

Product: Folylpolyglutamate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSTFPTLDAWLSHLETAHPVGIDMGLARVTKVKEALGLEFACPVITVGGTNGKGSTCALLETILLKAGYRVGCHTSPHLL
AFNERARIGGANVDDAALLPHFEAVEAARLSLAEPVTLTYFEFTTLVILRLFAASQLDAVILEVGLGGRLDAMNMLDADC
AVVTSIDIDHTEYLGDTREQIGFEKAGIFRPGKPAVCGDPAPPQTLIDHANAIGADLWLVGRDFRYETQPGNERQQWSYL
GRDKRYPALAYPALRGANQLINASAALAALESLRARLPVSAQDIRLGLANVELPGRFQVLPGKPAIVLDVAHNPHASAVL
AQNLGNMGFFPYTYAVFGAMRDKDIAGVLRQLKGEIDHWCVTDLPLPRAASAETLEAALREAGVEDGPDSSVTRYASPAE
AFRDTLKRASENDRIVVFGSFYTVAGVMAYRKSQQH

Sequences:

>Translated_436_residues
MSTFPTLDAWLSHLETAHPVGIDMGLARVTKVKEALGLEFACPVITVGGTNGKGSTCALLETILLKAGYRVGCHTSPHLL
AFNERARIGGANVDDAALLPHFEAVEAARLSLAEPVTLTYFEFTTLVILRLFAASQLDAVILEVGLGGRLDAMNMLDADC
AVVTSIDIDHTEYLGDTREQIGFEKAGIFRPGKPAVCGDPAPPQTLIDHANAIGADLWLVGRDFRYETQPGNERQQWSYL
GRDKRYPALAYPALRGANQLINASAALAALESLRARLPVSAQDIRLGLANVELPGRFQVLPGKPAIVLDVAHNPHASAVL
AQNLGNMGFFPYTYAVFGAMRDKDIAGVLRQLKGEIDHWCVTDLPLPRAASAETLEAALREAGVEDGPDSSVTRYASPAE
AFRDTLKRASENDRIVVFGSFYTVAGVMAYRKSQQH
>Mature_435_residues
STFPTLDAWLSHLETAHPVGIDMGLARVTKVKEALGLEFACPVITVGGTNGKGSTCALLETILLKAGYRVGCHTSPHLLA
FNERARIGGANVDDAALLPHFEAVEAARLSLAEPVTLTYFEFTTLVILRLFAASQLDAVILEVGLGGRLDAMNMLDADCA
VVTSIDIDHTEYLGDTREQIGFEKAGIFRPGKPAVCGDPAPPQTLIDHANAIGADLWLVGRDFRYETQPGNERQQWSYLG
RDKRYPALAYPALRGANQLINASAALAALESLRARLPVSAQDIRLGLANVELPGRFQVLPGKPAIVLDVAHNPHASAVLA
QNLGNMGFFPYTYAVFGAMRDKDIAGVLRQLKGEIDHWCVTDLPLPRAASAETLEAALREAGVEDGPDSSVTRYASPAEA
FRDTLKRASENDRIVVFGSFYTVAGVMAYRKSQQH

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=292, Percent_Identity=33.5616438356164, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI66932984, Length=292, Percent_Identity=33.5616438356164, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1788654, Length=423, Percent_Identity=42.789598108747, Blast_Score=297, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI71984923, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17553150, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17553148, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323760, Length=367, Percent_Identity=29.1553133514986, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324815, Length=298, Percent_Identity=28.8590604026846, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641571, Length=154, Percent_Identity=40.2597402597403, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24581568, Length=152, Percent_Identity=34.2105263157895, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 47032; Mature: 46901

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFPTLDAWLSHLETAHPVGIDMGLARVTKVKEALGLEFACPVITVGGTNGKGSTCALL
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEECCEEEECCCCCCCCHHHHH
ETILLKAGYRVGCHTSPHLLAFNERARIGGANVDDAALLPHFEAVEAARLSLAEPVTLTY
HHHHHHCCCEECCCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCEEEH
FEFTTLVILRLFAASQLDAVILEVGLGGRLDAMNMLDADCAVVTSIDIDHTEYLGDTREQ
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHCCCCEEEEEEECCCHHHHHCCHHHH
IGFEKAGIFRPGKPAVCGDPAPPQTLIDHANAIGADLWLVGRDFRYETQPGNERQQWSYL
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECCCCCCCHHHHHHH
GRDKRYPALAYPALRGANQLINASAALAALESLRARLPVSAQDIRLGLANVELPGRFQVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCCEEEC
PGKPAIVLDVAHNPHASAVLAQNLGNMGFFPYTYAVFGAMRDKDIAGVLRQLKGEIDHWC
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEE
VTDLPLPRAASAETLEAALREAGVEDGPDSSVTRYASPAEAFRDTLKRASENDRIVVFGS
ECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEC
FYTVAGVMAYRKSQQH
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STFPTLDAWLSHLETAHPVGIDMGLARVTKVKEALGLEFACPVITVGGTNGKGSTCALL
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEECCEEEECCCCCCCCHHHHH
ETILLKAGYRVGCHTSPHLLAFNERARIGGANVDDAALLPHFEAVEAARLSLAEPVTLTY
HHHHHHCCCEECCCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCEEEH
FEFTTLVILRLFAASQLDAVILEVGLGGRLDAMNMLDADCAVVTSIDIDHTEYLGDTREQ
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHCCCCEEEEEEECCCHHHHHCCHHHH
IGFEKAGIFRPGKPAVCGDPAPPQTLIDHANAIGADLWLVGRDFRYETQPGNERQQWSYL
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECCCCCCCHHHHHHH
GRDKRYPALAYPALRGANQLINASAALAALESLRARLPVSAQDIRLGLANVELPGRFQVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCCEEEC
PGKPAIVLDVAHNPHASAVLAQNLGNMGFFPYTYAVFGAMRDKDIAGVLRQLKGEIDHWC
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEE
VTDLPLPRAASAETLEAALREAGVEDGPDSSVTRYASPAEAFRDTLKRASENDRIVVFGS
ECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEC
FYTVAGVMAYRKSQQH
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]