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The map label for this gene is glyA1 [H]

Identifier: 238023788

GI number: 238023788

Start: 383885

End: 385147

Strand: Direct

Name: glyA1 [H]

Synonym: bglu_2g03230

Alternate gene names: 238023788

Gene position: 383885-385147 (Clockwise)

Preceding gene: 238023787

Following gene: 238023790

Centisome position: 13.58

GC content: 66.43

Gene sequence:

>1263_bases
ATGTTCAACTATTCCACCAGCACCATCGAAGCAGTCGATCCTGACCTCTGGCAGGCGATCCAGCAGGAGAACCAGCGCCA
GGAAGATCACATCGAGCTGATCGCCTCCGAGAACTACACGAGCCCGGCGGTGATGGCCGCGCAGGGCTCGCAGCTGACCA
ACAAGTATGCCGAGGGCTATCCCGGCAAGCGCTACTACGGCGGCTGCGAATACGTGGACGTGGTCGAGCAACTGGCGATC
GACCGGGTCAAGGCGCTGTTCGGCGCGCAAGCGGCCAACGTGCAGCCGAACTCGGGCTCGCAGGCCAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTGGCGCACGGCGGGCACCTCACGCACGGCTCGCCGG
TGAACATGTCGGGCAAGTGGTTCAACGTGGTGAGCTACGGCCTGGACGAAAGCGAGGACATCGACTACGAGGCGGCCGAT
CGGCTCGCGCAGGAGCACAAGCCGAAGATGATCGTGGCGGGGGCCTCGGCATTCGCGCTGAAGATCGACTTCGAGCGCCT
GGCGAAGATCGCGAAGTCGGTGGGCGCGTACCTGATGGTGGACATGGCGCACTACGCGGGGCTGATCGCGGCTGGGGTGT
ATCCGAACCCGGTGCCGCACGCGGACTTCGTGACGACGACCACGCACAAGAGCCTGCGCGGGCCGCGCGGCGGCGTGATT
CTGATGAAGTCGGAGTACGAGAAGCCGATCAACTCGGCGATTTTCCCCGGGATTCAGGGCGGCCCGCTGATGCACGTGAT
CGCGGCGAAGGCGGTGGCGTTCAAGGAAGCGGGCTCGGCGGAATTCAAGGCGTACCAGCAGCAGGTGGTGGAGAACGCGC
GGGTGCTGGCGCAGACGCTGGTCAAGCGCGGGCTGCGGATCGTGTCCGGGCGCACGGAAAGCCACGTGATGCTGGTGGAC
CTGCAGGCGAAGAAGATCACGGGCAAGGCGGCGGAAGCGGCGCTGGGCGCGGCGCACATCACGGTGAACAAGAACGCGAT
CCCGAACGACCCGGAGAAGCCGTTCGTGACGAGCGGGATTCGTCTGGGCTCGCCGGCGATGACGACGCGCGGGTTCGGCA
CGAAGGAGGCGGAGATCGTGGGCAACCTGATCGCGGACGTGCTGGACAATCCGGAGGACGCGGCCACGCTGGAGCGCGTG
CGCGCGCAGGTGGCCGAGCTGACCCGGCAGTTCCCGGTGTACGGCGGCCGTTCGGGCGCCTGA

Upstream 100 bases:

>100_bases
TTGAATAGCGCTGCCACGTATCAGGCAATCGGTTCGAAGCGCCGGGGGCCGCCGCGCGCGGCGCAGGGTAGGTTTTTTGA
TGACGGACGTCGGGAAAATC

Downstream 100 bases:

>100_bases
GCGATCGAGGCGCCGCCGGGTGCGCAGCCGTCGCCGCGCGTGAGGGCTCCACCGGCACGGGGGCGCTTGTCCTCCCGGCC
CGAGGCCGCGCCGGGCGGAT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFNYSTSTIEAVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYGGRSGA

Sequences:

>Translated_420_residues
MFNYSTSTIEAVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYGGRSGA
>Mature_420_residues
MFNYSTSTIEAVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAAD
RLAQEHKPKMIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERV
RAQVAELTRQFPVYGGRSGA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI261862350, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI261862348, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI19923315, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=40.625, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI22547186, Length=424, Percent_Identity=41.7452830188679, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI22547189, Length=382, Percent_Identity=41.8848167539267, Blast_Score=272, Evalue=5e-73,
Organism=Escherichia coli, GI1788902, Length=410, Percent_Identity=63.6585365853659, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25144732, Length=406, Percent_Identity=44.8275862068966, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI25144729, Length=406, Percent_Identity=44.8275862068966, Blast_Score=341, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=46.2287104622871, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=434, Percent_Identity=42.6267281105991, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24640005, Length=450, Percent_Identity=42, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI221329721, Length=450, Percent_Identity=42, Blast_Score=347, Evalue=8e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45136; Mature: 45136

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNYSTSTIEAVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAADRLAQEHKPKMIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTL
EECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERVRAQVAELTRQFPVYGGRSGA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFNYSTSTIEAVDPDLWQAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKALFGAQAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLDESEDIDYEAADRLAQEHKPKMIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEAGSAEFKAYQQQVVENARVLAQTL
EECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLQAKKITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGTKEAEIVGNLIADVLDNPEDAATLERVRAQVAELTRQFPVYGGRSGA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA