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The map label for this gene is uxuB [H]

Identifier: 238023668

GI number: 238023668

Start: 216499

End: 217971

Strand: Reverse

Name: uxuB [H]

Synonym: bglu_2g01890

Alternate gene names: 238023668

Gene position: 217971-216499 (Counterclockwise)

Preceding gene: 238023672

Following gene: 238023667

Centisome position: 7.71

GC content: 73.52

Gene sequence:

>1473_bases
ATGGCGAAACTCCTGAGCACCGCTGCGCTGTCGGCGCTGGCCCCGACCACACGACGGCCAACCTATGCGCGCGACCGGCT
GCGCCGCGGCATCGTCCATCTCGGGCTCGGCGCGTTCCATCGCGCGCATCAGGCGCTCTACACGGAGGCGCTGCTCGAGC
GCGGCGACGCACGCTGGGGCACGCTCGGCATCCATCTGCGCGAGCGCCGCATGGCCGACCGGCTCGCCGCGCAGGACACG
CTTTACTCGGTGACCGAAAGCGACGGCGAGGCCGCGCACAGTCGCGTGATCGGCGGCCTGCTCGGCGCGCTGCATGCGCC
CTCGGCGCTGTCCAGCGTGCTCGACGCGATCGCCGATCCCGGCGTCGCGATCATCAGCCTGACCGTAACCGAAAAGGGCT
ACTGCATCGCGCCCGCCAGCGGCCAACTCGACGAGCACGATCCCGACCTCCGGCGCGACATGCTCGCGCCCGACGCGCCG
CGCACCACGCTCGGCGTACTCGCCGCAGGCCTGCGCCGCCGCGCCGCCGCCGCGCCGCTGACGATCCTCTGTTGCGACAA
CATGACCGCCAACGGCGATACGCTGCGCCGGCTGCTGATGCAGTACGCAGGGCTCACCGACGCCGCGCTCGCGCGCCGGA
TCGGCGACACCATCGCGTTTCCGAACACCATGGTGGACCGCATCGTGCCGGCCGCGACGCCGGCCTCGCTCGCCGCGGCC
GAGGCACGCCTGGGGCTGCGCGACGAGGCCGCGATCGTCTGCGAACCGTTTACGCAATGGGTCGTCGAGGACCGCTTCAG
CGGTCCTCGGCCGGCCTGGGAGGACGCGGGCGCGCTGCTCACCGCGGACGTCCATCCCTACGAGGCGATGAAGCTGCGGC
TGCTCAACGGCTCGCATTCGGCGATCGCCTATCTCGGGCAGCTGCGCGGGCTCGCCACCGTGGCCGACGCGATGGCCGAC
CCGGCGCTGGCCGGCTTCGTGCATGGCCTGATGACCGAGGATCTGCTCGCCACGGTGGCCGTACCGGCCGGCTTCGACAT
CGGTGCCTATTGCCGCGACCTGCTCGCCCGCTTTCGCAATCCCACGCTCGCGCACGAGACGCGCCAGATCGCCACCGACG
GCACCCGGAAGGTGCCCATGCGCTGGCTGCCGGCCCTGCGCGAGAGCCTGGCCGCCGGCGTCGAGCGGCCACGGCTCGAA
CGCGCGCTGGCCGCCTGGCTGCATTTCCTGGATACGGCGCGCAGCGACGCGGGCGAGCCGCTCGTGCTCGGCGATCCCGG
TGCGGAGGCGCTGGCGGCCCGCCTGCAGTCGAGCGCCGCGCCGCTCGACAAGGCGCGGGCCGCGCTCGGCCACGCCAGCG
TGTTCGGCAGCGTGCCATGGCCGGAGGCGTTCGTCACGCGGCTCGCGGGGCATCTCGACACGCTGCGCCGCGCCGGCACC
GGCGCGCTGCTCGCCGTGCCCGGCCACCGCTGA

Upstream 100 bases:

>100_bases
ATACGGGCAATTCCTAGCGTTTACACCGATAAAATCGGCGATACATGACGCCTATGCTTGGCTCATCACCAAATCTACCA
TGGTAAATGCCAGTCCCACG

Downstream 100 bases:

>100_bases
GCGCCGCGGCACCGTTTACCGCGGCGCCCGGCCCGCGGGCCGGCGCCGCCTGCCCCGGCACGCGCGACACCGGGGACGGC
CCGCCGGCCGGACGCGCGAC

Product: mannitol dehydrogenase family protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MAKLLSTAALSALAPTTRRPTYARDRLRRGIVHLGLGAFHRAHQALYTEALLERGDARWGTLGIHLRERRMADRLAAQDT
LYSVTESDGEAAHSRVIGGLLGALHAPSALSSVLDAIADPGVAIISLTVTEKGYCIAPASGQLDEHDPDLRRDMLAPDAP
RTTLGVLAAGLRRRAAAAPLTILCCDNMTANGDTLRRLLMQYAGLTDAALARRIGDTIAFPNTMVDRIVPAATPASLAAA
EARLGLRDEAAIVCEPFTQWVVEDRFSGPRPAWEDAGALLTADVHPYEAMKLRLLNGSHSAIAYLGQLRGLATVADAMAD
PALAGFVHGLMTEDLLATVAVPAGFDIGAYCRDLLARFRNPTLAHETRQIATDGTRKVPMRWLPALRESLAAGVERPRLE
RALAAWLHFLDTARSDAGEPLVLGDPGAEALAARLQSSAAPLDKARAALGHASVFGSVPWPEAFVTRLAGHLDTLRRAGT
GALLAVPGHR

Sequences:

>Translated_490_residues
MAKLLSTAALSALAPTTRRPTYARDRLRRGIVHLGLGAFHRAHQALYTEALLERGDARWGTLGIHLRERRMADRLAAQDT
LYSVTESDGEAAHSRVIGGLLGALHAPSALSSVLDAIADPGVAIISLTVTEKGYCIAPASGQLDEHDPDLRRDMLAPDAP
RTTLGVLAAGLRRRAAAAPLTILCCDNMTANGDTLRRLLMQYAGLTDAALARRIGDTIAFPNTMVDRIVPAATPASLAAA
EARLGLRDEAAIVCEPFTQWVVEDRFSGPRPAWEDAGALLTADVHPYEAMKLRLLNGSHSAIAYLGQLRGLATVADAMAD
PALAGFVHGLMTEDLLATVAVPAGFDIGAYCRDLLARFRNPTLAHETRQIATDGTRKVPMRWLPALRESLAAGVERPRLE
RALAAWLHFLDTARSDAGEPLVLGDPGAEALAARLQSSAAPLDKARAALGHASVFGSVPWPEAFVTRLAGHLDTLRRAGT
GALLAVPGHR
>Mature_489_residues
AKLLSTAALSALAPTTRRPTYARDRLRRGIVHLGLGAFHRAHQALYTEALLERGDARWGTLGIHLRERRMADRLAAQDTL
YSVTESDGEAAHSRVIGGLLGALHAPSALSSVLDAIADPGVAIISLTVTEKGYCIAPASGQLDEHDPDLRRDMLAPDAPR
TTLGVLAAGLRRRAAAAPLTILCCDNMTANGDTLRRLLMQYAGLTDAALARRIGDTIAFPNTMVDRIVPAATPASLAAAE
ARLGLRDEAAIVCEPFTQWVVEDRFSGPRPAWEDAGALLTADVHPYEAMKLRLLNGSHSAIAYLGQLRGLATVADAMADP
ALAGFVHGLMTEDLLATVAVPAGFDIGAYCRDLLARFRNPTLAHETRQIATDGTRKVPMRWLPALRESLAAGVERPRLER
ALAAWLHFLDTARSDAGEPLVLGDPGAEALAARLQSSAAPLDKARAALGHASVFGSVPWPEAFVTRLAGHLDTLRRAGTG
ALLAVPGHR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=444, Percent_Identity=42.1171171171171, Blast_Score=342, Evalue=5e-95,
Organism=Escherichia coli, GI1787823, Length=472, Percent_Identity=41.3135593220339, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788497, Length=456, Percent_Identity=39.2543859649123, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994885, Length=408, Percent_Identity=26.4705882352941, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790028, Length=268, Percent_Identity=29.8507462686567, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=487, Percent_Identity=34.0862422997947, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6320765, Length=487, Percent_Identity=34.0862422997947, Blast_Score=283, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 52128; Mature: 51997

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLSTAALSALAPTTRRPTYARDRLRRGIVHLGLGAFHRAHQALYTEALLERGDARWG
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TLGIHLRERRMADRLAAQDTLYSVTESDGEAAHSRVIGGLLGALHAPSALSSVLDAIADP
EEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GVAIISLTVTEKGYCIAPASGQLDEHDPDLRRDMLAPDAPRTTLGVLAAGLRRRAAAAPL
CEEEEEEEEECCCEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCE
TILCCDNMTANGDTLRRLLMQYAGLTDAALARRIGDTIAFPNTMVDRIVPAATPASLAAA
EEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCHHHHHHHCCCCCCHHHHHH
EARLGLRDEAAIVCEPFTQWVVEDRFSGPRPAWEDAGALLTADVHPYEAMKLRLLNGSHS
HHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCHHHHEEEEECCCHH
AIAYLGQLRGLATVADAMADPALAGFVHGLMTEDLLATVAVPAGFDIGAYCRDLLARFRN
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PTLAHETRQIATDGTRKVPMRWLPALRESLAAGVERPRLERALAAWLHFLDTARSDAGEP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCE
LVLGDPGAEALAARLQSSAAPLDKARAALGHASVFGSVPWPEAFVTRLAGHLDTLRRAGT
EEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
GALLAVPGHR
CCEEECCCCC
>Mature Secondary Structure 
AKLLSTAALSALAPTTRRPTYARDRLRRGIVHLGLGAFHRAHQALYTEALLERGDARWG
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
TLGIHLRERRMADRLAAQDTLYSVTESDGEAAHSRVIGGLLGALHAPSALSSVLDAIADP
EEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GVAIISLTVTEKGYCIAPASGQLDEHDPDLRRDMLAPDAPRTTLGVLAAGLRRRAAAAPL
CEEEEEEEEECCCEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCE
TILCCDNMTANGDTLRRLLMQYAGLTDAALARRIGDTIAFPNTMVDRIVPAATPASLAAA
EEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHCCCHHHHHHHCCCCCCHHHHHH
EARLGLRDEAAIVCEPFTQWVVEDRFSGPRPAWEDAGALLTADVHPYEAMKLRLLNGSHS
HHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCHHHHEEEEECCCHH
AIAYLGQLRGLATVADAMADPALAGFVHGLMTEDLLATVAVPAGFDIGAYCRDLLARFRN
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PTLAHETRQIATDGTRKVPMRWLPALRESLAAGVERPRLERALAAWLHFLDTARSDAGEP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCE
LVLGDPGAEALAARLQSSAAPLDKARAALGHASVFGSVPWPEAFVTRLAGHLDTLRRAGT
EEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
GALLAVPGHR
CCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]