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The map label for this gene is srpA [H]

Identifier: 237814476

GI number: 237814476

Start: 4090740

End: 4091825

Strand: Direct

Name: srpA [H]

Synonym: GBP346_A4274

Alternate gene names: 237814476

Gene position: 4090740-4091825 (Clockwise)

Preceding gene: 237814475

Following gene: 237814477

Centisome position: 99.81

GC content: 70.63

Gene sequence:

>1086_bases
ATGGAACATCCTTCAACACCACCGGGCGACGGGCCGTCGCGCGGCTTCTGGCGATGGGCGCTGATCGGCGGCGCGGTGGC
GGCGGTCGCGGCGACGTTCGGCTACGTCGGCGGCTGGCTCGCGCCGCATCGGCTGACGCCACAGCGGCTCGTCGACGCGT
TGCAGCGCAATGGCGGCCTGCATCCGGGCTACCGGCGCAATCACGCGAAAGGCGTATGCGTGACGGGTTATTTCGAAGGC
AACGGCGCGGCAAGCGCGTATTCGACCGCACCCTTTTTCGCGGCGGTGCGCACGCCGGTGGTTGGGCGCTTCGCGCTGCC
GGGCGGCAATCCGTACGCGCCGGATAGCAGCGTGCCGATCCGCAGCCTCGCGCTGCGCCTGAGCGCGCCGGACGGCGAGC
AGTGGCGCACGGGGATGAACAGCATGCCGGTGTTTCCGGTGGCGACGCCGCGCGCGTTCTACGAACAGACGGTGGCGGGC
CGGCCCGATCCGAGAACGGGCAAGCCCGATCCGGCGAAGCTGAAGGCGTTCTTCGACGCGCATCCGGAGACGGCTGCGTT
TCGCGCATGGGTGAAGACGGCGAAGCCGAGCGCGAGCTACGTCACCGAGACGTATTACAGCCTGAACGCGTTCTATCTCG
TCGATGCGGCGGGAAGGCGGCAGGCGGTGCGCTGGCGCGTCGCGCCGGAGCGGATGGCCGATGCGGGCGAAAGCGCGAAG
GCCGGCGATCCGAACGTGTTGCGGGAGGATCTGGCGCGGCGCATCGGTTCCGGGCCGCAGCGCTGGCATTTGCTGCTCAC
GCTGGCGGAGCCGGGCGACCCCGTCGACGACGCGACGCGCGCATGGCCCGCGACTCGCACGACGATCGACGCGGGCACGC
TGGTGCTCGATCGCGTGGAGGCGCAGGACAGCGGGCCGTGCCGCGACGTCAACTACGACCCGACGATCCTGCCCGACGGC
ATCCGTGCGTCGGGCGACCCGCTGCTCGCCGCGCGCTCGGCCGCGTATGCGGATTCGTATCTGCGGCGCACGAGCGAAGA
AGCCGGAATGCCCGGCGCGGCGCATCCGCTTTCGGAGAAACGATGA

Upstream 100 bases:

>100_bases
TTATTCCATGCGTTCGCAAAAAAATTTCGATGGAATAAACCGGGCGGCGGGCCGTCATACGCGCGTTCGACACAGGACCT
GACGGTCGGGAGCGTACACG

Downstream 100 bases:

>100_bases
TGAAGACGACGTTCAGCCCGCTCGCGCGGCTGCTGCATTGGGTGATGGCGGCGATGATCGTGTCGATGCTGTTCGTCGGC
GCGGGGATGGTGACGACGGT

Product: catalase

Products: O2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MEHPSTPPGDGPSRGFWRWALIGGAVAAVAATFGYVGGWLAPHRLTPQRLVDALQRNGGLHPGYRRNHAKGVCVTGYFEG
NGAASAYSTAPFFAAVRTPVVGRFALPGGNPYAPDSSVPIRSLALRLSAPDGEQWRTGMNSMPVFPVATPRAFYEQTVAG
RPDPRTGKPDPAKLKAFFDAHPETAAFRAWVKTAKPSASYVTETYYSLNAFYLVDAAGRRQAVRWRVAPERMADAGESAK
AGDPNVLREDLARRIGSGPQRWHLLLTLAEPGDPVDDATRAWPATRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTILPDG
IRASGDPLLAARSAAYADSYLRRTSEEAGMPGAAHPLSEKR

Sequences:

>Translated_361_residues
MEHPSTPPGDGPSRGFWRWALIGGAVAAVAATFGYVGGWLAPHRLTPQRLVDALQRNGGLHPGYRRNHAKGVCVTGYFEG
NGAASAYSTAPFFAAVRTPVVGRFALPGGNPYAPDSSVPIRSLALRLSAPDGEQWRTGMNSMPVFPVATPRAFYEQTVAG
RPDPRTGKPDPAKLKAFFDAHPETAAFRAWVKTAKPSASYVTETYYSLNAFYLVDAAGRRQAVRWRVAPERMADAGESAK
AGDPNVLREDLARRIGSGPQRWHLLLTLAEPGDPVDDATRAWPATRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTILPDG
IRASGDPLLAARSAAYADSYLRRTSEEAGMPGAAHPLSEKR
>Mature_361_residues
MEHPSTPPGDGPSRGFWRWALIGGAVAAVAATFGYVGGWLAPHRLTPQRLVDALQRNGGLHPGYRRNHAKGVCVTGYFEG
NGAASAYSTAPFFAAVRTPVVGRFALPGGNPYAPDSSVPIRSLALRLSAPDGEQWRTGMNSMPVFPVATPRAFYEQTVAG
RPDPRTGKPDPAKLKAFFDAHPETAAFRAWVKTAKPSASYVTETYYSLNAFYLVDAAGRRQAVRWRVAPERMADAGESAK
AGDPNVLREDLARRIGSGPQRWHLLLTLAEPGDPVDDATRAWPATRTTIDAGTLVLDRVEAQDSGPCRDVNYDPTILPDG
IRASGDPLLAARSAAYADSYLRRTSEEAGMPGAAHPLSEKR

Specific function: Decomposes Hydrogen Peroxide Into Water And Oxygen; Serves To Protect Cells From The Toxic Effects Of Hydrogen Peroxide. [C]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=295, Percent_Identity=26.4406779661017, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI48994891, Length=322, Percent_Identity=24.223602484472, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71998444, Length=299, Percent_Identity=25.752508361204, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19920968, Length=292, Percent_Identity=27.0547945205479, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17981717, Length=292, Percent_Identity=24.6575342465753, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020835
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase [H]

EC number: 1.11.1.6

Molecular weight: Translated: 38818; Mature: 38818

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHPSTPPGDGPSRGFWRWALIGGAVAAVAATFGYVGGWLAPHRLTPQRLVDALQRNGGL
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
HPGYRRNHAKGVCVTGYFEGNGAASAYSTAPFFAAVRTPVVGRFALPGGNPYAPDSSVPI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
RSLALRLSAPDGEQWRTGMNSMPVFPVATPRAFYEQTVAGRPDPRTGKPDPAKLKAFFDA
HHEEEEECCCCCHHHHCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC
HPETAAFRAWVKTAKPSASYVTETYYSLNAFYLVDAAGRRQAVRWRVAPERMADAGESAK
CCCHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCCCEEEEEECHHHHHCCCCCCC
AGDPNVLREDLARRIGSGPQRWHLLLTLAEPGDPVDDATRAWPATRTTIDAGTLVLDRVE
CCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEECCCCEEEEECC
AQDSGPCRDVNYDPTILPDGIRASGDPLLAARSAAYADSYLRRTSEEAGMPGAAHPLSEK
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
R
C
>Mature Secondary Structure
MEHPSTPPGDGPSRGFWRWALIGGAVAAVAATFGYVGGWLAPHRLTPQRLVDALQRNGGL
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
HPGYRRNHAKGVCVTGYFEGNGAASAYSTAPFFAAVRTPVVGRFALPGGNPYAPDSSVPI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
RSLALRLSAPDGEQWRTGMNSMPVFPVATPRAFYEQTVAGRPDPRTGKPDPAKLKAFFDA
HHEEEEECCCCCHHHHCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC
HPETAAFRAWVKTAKPSASYVTETYYSLNAFYLVDAAGRRQAVRWRVAPERMADAGESAK
CCCHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCCCEEEEEECHHHHHCCCCCCC
AGDPNVLREDLARRIGSGPQRWHLLLTLAEPGDPVDDATRAWPATRTTIDAGTLVLDRVE
CCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEECCCCEEEEECC
AQDSGPCRDVNYDPTILPDGIRASGDPLLAARSAAYADSYLRRTSEEAGMPGAAHPLSEK
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Heme Group. [C]

Metal ions: NA

Kcat value (1/min): 980000 [C]

Specific activity: NA

Km value (mM): 18.2 {H2O2}} 10 {H2O2}} 3.7 {H2O2}} [C]

Substrates: H2O2

Specific reaction: 2 H2O2 = O2 + 2 H2O

General reaction: Redox reaction [C]

Inhibitor: 3-Amino-1-H-1, 2, 4-triazolecoli, Rhodopseudomonascapsulata; Dianisidine; H2O2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7536734 [H]