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The map label for this gene is oprM [H]

Identifier: 237814412

GI number: 237814412

Start: 4032342

End: 4033958

Strand: Reverse

Name: oprM [H]

Synonym: GBP346_A4210

Alternate gene names: 237814412

Gene position: 4033958-4032342 (Counterclockwise)

Preceding gene: 237814413

Following gene: 237814402

Centisome position: 98.42

GC content: 73.72

Gene sequence:

>1617_bases
ATGCCGCAAGTCCCACATCCGCGCGCGCGCCGCGCGTTGAGCGCCGCCGTCGCCGCGGCCACCGCCGTGCTGCTCGCCGG
CTGCGCGGTCGGGCCCGACTATCACCGTCCCGACGCGGCGATTCCCGCCGCGTACAAGGAAGCGCCGCCCGGCTGGAAGC
TCGCGCAGCCGGCCGACCGCGCGGACCGCGGCCCGTGGTGGTCGATCTACGACGATGCGCAACTGAATGCGCTGATCGAC
AAGCTCAACGCGTCGAACCAGACCGTCGCGCAATACGCGGCCGCGTACCGGCAGGCGCGCGCGCTCGTCGCCGAGGCGCG
CGCGTCGTACTTTCCGACGCTCGGGCTGACCGCGAGCGAATCGCGCGCGTCGAGCGCGCTGTCGTCGGGCACCGCGTCGC
GCGGCACGACGCGCACGGTCGGCAACACGTACAGCGTCGGCCTCGATGCGTCGTGGGAGCCGGACCTGTGGGGCAAGGTG
AGTCGCACGGTCGGCGCGCAGAAGGCAGGAGAAGCGGCCGCGGCCGCCGATCTCGCGAACGCGCGGCTGTCCGCGCAGGC
GACGCTCGCGCAGACCTACTTCCAGCTGCGCGCCGCGGACGCGACGCAAAAGCTGCTCGACGATACCGTCGAGTCGTACC
GGAAATCGCTGCAGCTCACGCAGAACCAGTACGCGCAGGGCGTCGCCGCGCGCGCGGACGTGATCCAGGCGCAGACCCAG
CTCCAATCGGCGCAGGCCGCCGCGATCGACAACGGCATCGCGCGCGCGCAGTACGAGCACGCGATCGCGACGCTCGTCGG
CGAGCCGGCGCCGACGTTCTCGCTGCCGCCGATGCCGCTCACGGCCGAGCCGCCCGCGATGCCGATCGACGTGCCGTCGG
CGATCCTCGAGCGGCGGCCCGACGTCGCCGCCGCCGAGCGGCGCGCGGCCGCCGCGAACGAGCAGATCGGCGTCGCGATC
GCCGCGTTCTTCCCGACGCTCACGCTGTCCGCATCGGGCGGCTTTCAGAGCTCGGTGTGGTCGCAGCTGTTCACGCTGCC
CGCACGCTTCTGGTCGGTCGGCCCGCAGCTCGCCGCGACGCTGTTCGACGCGGGCCTGCGCGCCGCGCAGACGGAAGCGG
CGCGCGCGACCTACGATCAGGACGTCGCCGCGTACCGGGCGGCCGTGCTCTCCGCGTTCCAGGACGTCGAGGACAACCTC
GCGTCGCAGCGCATCCTCGAGCAGGAAATCGTCGTGCAGCGGCAGGCGGTCGAATCCGCGCAGCACTCGCTCGACATCAC
GCTCAACCAGTACAAGGCGGGCACCGTCGGCTATCTGAACGTGCTGACCGCGCAGACAACCGCGTTCAGCGCACGGCAGA
AGCTCGCGACCCTCTCCGGGCAGCGGATGGTGTCGTCGGTCGGACTCGTGAAAGCGCTCGGCGGCGGATGGGACGGGTCG
CAGATCGCGCGCGAGACAGGCGGCATGCAAGCGCCCGCCGCGCCGGCCGGGGCGGCGGCGCCGGCGGCCATGCCGGCCGC
GGCCGTTGCGCCGGCGGCACGCCCGGCGGCCGTGGTCGCGGCGGCCGGGCCCGATACGCAGGCTCGCCGGCCGCGCGCCA
CGCCCGCCGCGCAATAG

Upstream 100 bases:

>100_bases
CCCGCACCCGTCAGTTACCATTTCGGCCACGCCTCGGCGTTTCGGCCGCCTCGCCCGCTCGTCCGGCTCACCGGCGGCCG
CCTCGACAGGAATCCAGAAC

Downstream 100 bases:

>100_bases
CGCAACCGGGCCGCACGCCGGTCCTCGGATCGGCGGCTCACGCCTGGCGACATCGATGTGCGCCCGGCGGCCAACCCTTT
GTCGAGCCCGCCGTCAAACG

Product: outer membrane efflux lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPQVPHPRARRALSAAVAAATAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKLAQPADRADRGPWWSIYDDAQLNALID
KLNASNQTVAQYAAAYRQARALVAEARASYFPTLGLTASESRASSALSSGTASRGTTRTVGNTYSVGLDASWEPDLWGKV
SRTVGAQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVESYRKSLQLTQNQYAQGVAARADVIQAQTQ
LQSAQAAAIDNGIARAQYEHAIATLVGEPAPTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAI
AAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNL
ASQRILEQEIVVQRQAVESAQHSLDITLNQYKAGTVGYLNVLTAQTTAFSARQKLATLSGQRMVSSVGLVKALGGGWDGS
QIARETGGMQAPAAPAGAAAPAAMPAAAVAPAARPAAVVAAAGPDTQARRPRATPAAQ

Sequences:

>Translated_538_residues
MPQVPHPRARRALSAAVAAATAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKLAQPADRADRGPWWSIYDDAQLNALID
KLNASNQTVAQYAAAYRQARALVAEARASYFPTLGLTASESRASSALSSGTASRGTTRTVGNTYSVGLDASWEPDLWGKV
SRTVGAQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVESYRKSLQLTQNQYAQGVAARADVIQAQTQ
LQSAQAAAIDNGIARAQYEHAIATLVGEPAPTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAI
AAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNL
ASQRILEQEIVVQRQAVESAQHSLDITLNQYKAGTVGYLNVLTAQTTAFSARQKLATLSGQRMVSSVGLVKALGGGWDGS
QIARETGGMQAPAAPAGAAAPAAMPAAAVAPAARPAAVVAAAGPDTQARRPRATPAAQ
>Mature_537_residues
PQVPHPRARRALSAAVAAATAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKLAQPADRADRGPWWSIYDDAQLNALIDK
LNASNQTVAQYAAAYRQARALVAEARASYFPTLGLTASESRASSALSSGTASRGTTRTVGNTYSVGLDASWEPDLWGKVS
RTVGAQKAGEAAAAADLANARLSAQATLAQTYFQLRAADATQKLLDDTVESYRKSLQLTQNQYAQGVAARADVIQAQTQL
QSAQAAAIDNGIARAQYEHAIATLVGEPAPTFSLPPMPLTAEPPAMPIDVPSAILERRPDVAAAERRAAAANEQIGVAIA
AFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAATLFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLA
SQRILEQEIVVQRQAVESAQHSLDITLNQYKAGTVGYLNVLTAQTTAFSARQKLATLSGQRMVSSVGLVKALGGGWDGSQ
IARETGGMQAPAAPAGAAAPAAMPAAAVAPAARPAAVVAAAGPDTQARRPRATPAAQ

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=469, Percent_Identity=29.4243070362473, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI2367348, Length=483, Percent_Identity=26.2939958592132, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55988; Mature: 55857

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVPHPRARRALSAAVAAATAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKLAQPADR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
ADRGPWWSIYDDAQLNALIDKLNASNQTVAQYAAAYRQARALVAEARASYFPTLGLTASE
CCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SRASSALSSGTASRGTTRTVGNTYSVGLDASWEPDLWGKVSRTVGAQKAGEAAAAADLAN
HHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHH
ARLSAQATLAQTYFQLRAADATQKLLDDTVESYRKSLQLTQNQYAQGVAARADVIQAQTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSAQAAAIDNGIARAQYEHAIATLVGEPAPTFSLPPMPLTAEPPAMPIDVPSAILERRP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
DVAAAERRAAAANEQIGVAIAAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAAT
CHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
LFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQRILEQEIVVQRQAVESA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHSLDITLNQYKAGTVGYLNVLTAQTTAFSARQKLATLSGQRMVSSVGLVKALGGGWDGS
HHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
QIARETGGMQAPAAPAGAAAPAAMPAAAVAPAARPAAVVAAAGPDTQARRPRATPAAQ
HHHHHHCCCCCCCCCCCCCCCHHCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQVPHPRARRALSAAVAAATAVLLAGCAVGPDYHRPDAAIPAAYKEAPPGWKLAQPADR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
ADRGPWWSIYDDAQLNALIDKLNASNQTVAQYAAAYRQARALVAEARASYFPTLGLTASE
CCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SRASSALSSGTASRGTTRTVGNTYSVGLDASWEPDLWGKVSRTVGAQKAGEAAAAADLAN
HHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHH
ARLSAQATLAQTYFQLRAADATQKLLDDTVESYRKSLQLTQNQYAQGVAARADVIQAQTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSAQAAAIDNGIARAQYEHAIATLVGEPAPTFSLPPMPLTAEPPAMPIDVPSAILERRP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
DVAAAERRAAAANEQIGVAIAAFFPTLTLSASGGFQSSVWSQLFTLPARFWSVGPQLAAT
CHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
LFDAGLRAAQTEAARATYDQDVAAYRAAVLSAFQDVEDNLASQRILEQEIVVQRQAVESA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHSLDITLNQYKAGTVGYLNVLTAQTTAFSARQKLATLSGQRMVSSVGLVKALGGGWDGS
HHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
QIARETGGMQAPAAPAGAAAPAAMPAAAVAPAARPAAVVAAAGPDTQARRPRATPAAQ
HHHHHHCCCCCCCCCCCCCCCHHCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]