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The map label for this gene is ahcY

Identifier: 237814229

GI number: 237814229

Start: 3855013

End: 3856434

Strand: Reverse

Name: ahcY

Synonym: GBP346_A4024

Alternate gene names: 237814229

Gene position: 3856434-3855013 (Counterclockwise)

Preceding gene: 237814231

Following gene: 237814228

Centisome position: 94.09

GC content: 64.14

Gene sequence:

>1422_bases
ATGAACGCCGCTGTCATCGATTCCCATTCCGCACAAGATTACGTCGTCGCCGATATCGCGCTGGCCGGCTGGGGCCGCAA
GGAACTGAACATCGCCGAGACCGAGATGCCCGGGCTCGTGCAGATCCGCGACGAATACAAGGCGCAGCAGCCGCTGAAGG
GCGCGCGCATCGCCGGCTCGCTGCACATGACGATCCAGACGGGCGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCGGAC
GTTCGCTGGGCGTCGTGCAACATCTTCTCGACGCAGGACCACGCGGCCGCCGCGATCGTCGAGGCCGGCACGCCCGTCTT
CGCGTTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATCTTCGAATGGCCGAACGGCGAGTTCGCGA
ACATGATCCTTGATGACGGCGGCGACGCAACGCTGCTGCTGATCCTCGGCTCGAAGGCCGAGAAGGACCGCTCGGTGATC
GCCCGGCCGACCAACGAGGAAGAAGTCGCGCTCTTCAAGTCGATCGAGCGCCACCTCGAAATCGACGGCAGCTGGTACTC
GAAGCGCCTCGCGCACATCAAGGGCGTGACCGAAGAGACGACGACGGGCGTGCACCGCCTGTACCAGATGGAAAAGGACG
GCCGCCTGCCGTTCCCGGCGTTCAACGTCAACGATTCCGTGACGAAATCGAAGTTCGACAACCTGTACGGCTGCCGCGAG
TCGCTCGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGATCGCGGTGGTCGCGGGCTACGGCGACGT
GGGCAAGGGCTGCGCGCAATCGCTGCGCGGCCTGGGCGCGACCGTGTGGGTGACCGAAATCGATCCGATCTGCGCGCTGC
AGGCGGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCGGCCGACAAGGCCGACATCTTCGTGACGGCGACCGGC
AACTACCACGTGATCAACCACGATCACATGAAGGCGATGCGCCATAACGCGATCGTCTGCAACATCGGTCACTTCGATTC
GGAAATCGACGTCGCGTCGACCCGCCAGTACCAGTGGGAAAACATCAAGCCGCAGGTCGACCACATCATCTTCCCGGACG
GCAAGCGCGTGATCCTGCTGGCCGAAGGCCGCCTCGTGAACCTCGGCTGCGCGACCGGCCACCCGTCGTTCGTGATGTCG
AACTCGTTCACGAATCAGACCCTCGCGCAGATCGAGCTGTTCACGCGCGGCGGCGAGTACGCCAACAAGGTGTACGTGCT
GCCGAAGCATCTCGACGAAAAGGTCGCGCGCCTGCACCTCGCGCGCATCGGCGCGCAGCTCTCCGAGCTGTCGGACGATC
AGGCGGCGTACATCGGCGTGTCGAAGGCGGGCCCGTTCAAGCCGGATCACTATCGTTACTGA

Upstream 100 bases:

>100_bases
CATCGTCGCATAGCGGCGATCGTTTTCGCCGAGACCGGCCGCTTACTTGAACGGCGCTCACGTCACAATTTTCTAGAACT
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
TATCTTGATCCGTACCCGGCGCGCGGGCGCCGGGCGGCCCGCCGCCTGACGCCCGCCCGCGCGGCGCGCAGTCGGCACGG
CACCGCCGCCCGGCGCGCCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNAAVIDSHSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
ARPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVSKAGPFKPDHYRY

Sequences:

>Translated_473_residues
MNAAVIDSHSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
ARPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVSKAGPFKPDHYRY
>Mature_473_residues
MNAAVIDSHSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
ARPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVSKAGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.7402597402597, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.0909090909091, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=49.7872340425532, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=49.7872340425532, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=49.7872340425532, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=49.7872340425532, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=50, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17506425, Length=471, Percent_Identity=59.2356687898089, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=57.9710144927536, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=59.8712446351931, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.1061571125265, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.4669509594883, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.3589743589744, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_BURM7 (A3MQW7)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001082653.1
- ProteinModelPortal:   A3MQW7
- SMR:   A3MQW7
- GeneID:   4894372
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_3134
- TIGR:   BMA10247_3134
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   BMAL320389:BMA10247_3134-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52202; Mature: 52202

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 64-64 BINDING 139-139 BINDING 199-199 BINDING 229-229 BINDING 233-233 BINDING 234-234 BINDING 286-286 BINDING 321-321 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAVIDSHSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGS
CCCEEECCCCCCCEEEEEEEEECCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIARPTNEEEVALFKSIERHLE
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHEE
IDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWE
EEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTRGGEY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVSKAGPFKPDHYRY
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAAVIDSHSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGS
CCCEEECCCCCCCEEEEEEEEECCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIARPTNEEEVALFKSIERHLE
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHEE
IDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWE
EEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTRGGEY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVSKAGPFKPDHYRY
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA