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The map label for this gene is lysA [H]

Identifier: 237814107

GI number: 237814107

Start: 3745106

End: 3746377

Strand: Direct

Name: lysA [H]

Synonym: GBP346_A3893

Alternate gene names: 237814107

Gene position: 3745106-3746377 (Clockwise)

Preceding gene: 237814106

Following gene: 237814114

Centisome position: 91.38

GC content: 68.63

Gene sequence:

>1272_bases
ATGACTCAAGCTGCATTCGACTACGTCGACGGCACGCTCCACGCCGAGCGCGTGAGCACCGTCGAGCTCGCCGAGCGTTT
CGGCACCCCGCTCTTCGTCTATTCGCGCGCCGCGCTCACCGCAGCCTACGAGGCCTACGCGAAAGCCTGCGCCGGCCGCC
GCGCGTCGATTCACGTCGCCGTGAAGGCGAACAGCAACCTCGGCGTGCTGAACGTGTTCGCGCGTCTCGGCGCGGGCTTC
GACATCGTGTCGGGCGGCGAGCTCGCGCGCGTGCTCGCGGCGGGCGGCCGCGCGCGGGACGTCGTGTTCTCGGGCGTCGG
CAAGAGCGCCGACGAAATGCGCGTCGCACTCGAAGCAGGCGTGAAGTGCTTCAACGTCGAATCGATCCCGGAGCTCGACC
GGCTGAACGCCGTCGCGGCATCGCTCGGCAAGCGCGCGCCCGTGTCGCTGCGGGTGAATCCGGACGTCGACCCGAAGACG
CATCCGTACATCTCGACGGGGCTGAAGGCAAACAAGTTCGGTATCGCGTTCGACGACGCGCGCGCGACGTACCGCGCGGC
CGCCGCGCAGCCGAACCTCGAAGTCGTCGGCATCGACTGCCACATCGGCTCGCAGATCACCGAGCTGAGCCCGTACCTCG
ACGCGATCGACAAGCTGCTCGATCTCGTCGAGCGGATCGAGGCGGACGGCGTGCAGATCCATCACGTCGACGTCGGCGGC
GGGCTCGGCATCACGTATGACGACGAAACGCCGCCCGACATCGGCGCCTACGTGCGCGCGGTGCTCGCGCGCATCGATGC
GCGCGGCCACGGCCAGCGCGAAATCTGGTTCGAGCCGGGCCGCTCGCTGACGGGCAACGCCGGCATTCTGCTCACGCGCG
TCGAATTCCTGAAGCAGGGCGAAGAGAAGAACTTCGCGATCGTCGACGCGGCGATGAACGACCTCGCGCGCCCCGCGATG
TACCAGGCGTTTCACGCGATCGTGCCGGTTGCGCCGCGCACGGACGTCGCGGCCGCGGTGTACGACATCGTCGGTCCCGT
CTGCGAGAGCGGCGACTGGCTTGGGCGCGAGCGCTCGCTCGCGATCGCGCCCGGCGATCTGCTCGCGATCCGCTCGGCGG
GCGCGTATGGCTTCACGATGAGCTCGAACTACAATACGCGGCCGCGCGCGGCGGAAGTGATCGTCGATGGCGCGAACGCG
CATCTGGTACGGCCGCGCGAGACGGTCGAAAGCCTGTTCGAGCACGAAACGATCCTGCCCGAAGGCCGGTAA

Upstream 100 bases:

>100_bases
GCCGACGCGCCGCTCACGCTGTCGCCCGACCTGTCGACGCAACGCATGCCGAAGGCCGCGCCCGCGTCCGGCGCTTCCTC
CGCCCAATGACCGATCCTGC

Downstream 100 bases:

>100_bases
GCGCCGGCACGCGGCGCTCGCACGACGCATCGGCAGCCGCCGGCAATTCGATCATTCGACAAACCGGCGGGCCCGATCAA
AAAAGGCGATGTCCAACAAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAAQPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANA
HLVRPRETVESLFEHETILPEGR

Sequences:

>Translated_423_residues
MTQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAAQPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANA
HLVRPRETVESLFEHETILPEGR
>Mature_422_residues
TQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGFD
IVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTH
PYISTGLKANKFGIAFDDARATYRAAAAQPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGGG
LGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAMY
QAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAH
LVRPRETVESLFEHETILPEGR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=23.4285714285714, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789203, Length=429, Percent_Identity=32.8671328671329, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=343, Percent_Identity=24.7813411078717, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586474, Length=389, Percent_Identity=28.0205655526992, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24586472, Length=341, Percent_Identity=26.3929618768328, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45237; Mature: 45105

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCCHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCC
RATYRAAAAQPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
HHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSL
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAHLVRPRETVESLFEHETILP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCC
EGR
CCC
>Mature Secondary Structure 
TQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCC
RATYRAAAAQPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
HHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSL
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAHLVRPRETVESLFEHETILP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCC
EGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]