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The map label for this gene is hemA [H]

Identifier: 237813979

GI number: 237813979

Start: 3627686

End: 3628990

Strand: Direct

Name: hemA [H]

Synonym: GBP346_A3763

Alternate gene names: 237813979

Gene position: 3627686-3628990 (Clockwise)

Preceding gene: 237813978

Following gene: 237813980

Centisome position: 88.51

GC content: 68.28

Gene sequence:

>1305_bases
TTGGACATGCAGCTCCTCACGATCGGAATCAACCACCACACTGCGCCTGTCGCCTTGCGCGAACGCGTGGCGTTTCCGCT
CGAACAGATCAAGCCCGCATTGTCGACGTTCAAGAGCGTCTTCCTCGGCCATCCGGCGCCGAACGCACCCGAAGCGGCGA
TCCTGTCGACCTGCAATCGCACTGAACTGTATTGCGCGACCAACGATCGCGCCGCGCGCGACGCCGCGATCCGCTGGATG
TCCGACTACCACCGGATTCCCGCCGACGAGCTCGCGCCGCACGTGTACGCGCTGCCGCAATCCGAGGCGGTGCGCCACGC
GTTTCGCGTCGCGTCCGGGCTCGATTCGATGGTGCTCGGCGAAACGCAGATCCTCGGCCAGATGAAGAACGCGGTACGCA
CCGCGTCCGAGGCGGGTTCGCTCGGCACCTACCTGAACCAGCTGTTCCAGCGCACGTTCGCGGTCGCGAAGGAAGTGCGC
GGCACGACCGAGATCGGCGCGCAGTCGGTGTCGATGGCGGCTGCGGCCGTGCGCCTCGCACAGCGCATCTTCGAGCAGGT
CGCGCAGCAGCGCGTGCTGTTCATCGGCGCGGGCGAGATGATCGAGCTCTGCGCGACCCACTTCGCCGCGCAGGGCCCGC
GCGAGCTCGTCGTCGCGAACCGCACCGCCGAGCGCGGCGCGAAGCTCGCCGAGCGCTTCGGCGGCCGCGCGATGCCGCTC
GCCGATCTGCCCGCGCGCATGCACGAGTTCGACATCATCGTGTCGTGCACGGCATCGACGCTGCCGATCATCGGTCTCGG
CGCCGTCGAGCGCGCGGTGAAGGCGCGCCGCCACCGGCCGATCTTCATGGTCGACCTCGCGGTGCCGCGCGACATCGAGC
CCGAAGTCGGCAAGCTGAAGGATGTGTTCCTCTATACCGTCGACGATCTCGGCGCGATCGTGCGCGAAGGCAATGCGTCG
CGGCAGGCGGCCGTCGCGCAGGCCGAGGCGATCATCGAGACGCGCGTGCAGAATTTCATGCAGTGGCTCGACGCACGCAG
CATCGTGCCCGTGATCCGTCACATGCATACGCAGGCGGACGCGTTGCGCCGCGCGGAAGTCGAGCGCGCGCGCAAGATGC
TCGCGCGCGGCGACGATCCGGACGCCGTGCTCGATGCGCTGTCGCAAGCGCTCACCAACAAGCTGATTCACGGCCCGACG
AGCGCGCTCAACCGCGCGAACGGCGCCGATCGCGATTCGCTGATCGACCTGATGCGCGGCTTCTACCAGCACGCGCCCCG
CTCGTCGGACACGTCGGACCGTTAG

Upstream 100 bases:

>100_bases
GACGGCCGGCGGCCGCCCGCGCCCCGCGAACGGGCCGCGACATGCGCCGACCATGGATTTGTCGTCGAAACGCTATAATA
TGGGACTAAACGATAGCCTC

Downstream 100 bases:

>100_bases
CGGCGCCCGCCGGCCCGCCCCTCCTTCCCCTTTTCGAATCCTTCCCTGGGAGCATCGCTCCGCACCATGAAGACGAGCAT
GCAAAGCAAGCTCGACCAGC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWM
SDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVR
GTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPL
ADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNAS
RQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPT
SALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR

Sequences:

>Translated_434_residues
MDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWM
SDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVR
GTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPL
ADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNAS
RQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPT
SALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR
>Mature_434_residues
MDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWM
SDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVR
GTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPL
ADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNAS
RQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPT
SALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=405, Percent_Identity=45.679012345679, Blast_Score=347, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47546; Mature: 47546

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNR
CCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
TELYCATNDRAARDAAIRWMSDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLG
CEEEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHH
ETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPL
HHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHCCCCCCH
ADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLK
HHHHHHHHHHHEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHH
DVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQAD
HHHEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPTSALNRANGADRDSLIDLMRG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHH
FYQHAPRSSDTSDR
HHHHCCCCCCCCCC
>Mature Secondary Structure
MDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNR
CCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
TELYCATNDRAARDAAIRWMSDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLG
CEEEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHCCHHHHHH
ETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPL
HHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHCCCCCCH
ADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLK
HHHHHHHHHHHEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHH
DVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQAD
HHHEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPTSALNRANGADRDSLIDLMRG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHH
FYQHAPRSSDTSDR
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA