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The map label for this gene is gabP [H]

Identifier: 237813965

GI number: 237813965

Start: 3617321

End: 3619084

Strand: Reverse

Name: gabP [H]

Synonym: GBP346_A3749

Alternate gene names: 237813965

Gene position: 3619084-3617321 (Counterclockwise)

Preceding gene: 237813966

Following gene: 237813962

Centisome position: 88.3

GC content: 67.06

Gene sequence:

>1764_bases
GTGGCGGTGTCGAGCAAATCGCGCGGCCGCCGCGCGTTCGTCGATTCACCAAGTGGTTCTATCGGAATTCGTGAATTGGT
TCTTAGTCGCGAACCGTTTGATGCTTACACTGCATCGCTTCGAAGGCGGCCGATCACGATGCCGACGACAGGCGCGCCGC
GATGCGCCGCCGCGATGCGCGGCGCATCGCGAACGCAGCCTCGCAGACCTGCGTGGCGCACCTGTCCGGGCGGCCGCAGG
CATGACGTCCGATCGACGCGCGGCGCGCATTGCGCCGCGCACGGTTCGATAACAACAAAGCCCCCGCGCCGCCTTCATGC
GATGCCCGGTCACACCGGAACCGTTTTTTTGGAGGGAGACATGGAAGGAAGTCAGACAGGCCTCGGAACCGGCCTGAAGC
AGCGTCACGTCACGATGCTGTCGATCGCGGGCGTGATCGGCGCCGGGTTGTTCGTCGGTTCGGGGCATGCGATCGCGGAG
GCCGGGCCGGCCGCGCTGATCGCGTACGCGATCGCGGGGCTGCTCGTCGTGCTCGTGATGCGCATGCTCGGCGAGATGGC
GGTTGCGCAGCCGGACAGCGGTTCGTTCTCGACCTACGCCGATCGCGCGATCGGCCATTGGGCGGGCTTCACGATCGGCT
GGCTCTACTGGTGGTTCTGGGTGCTCGTGATTCCGATCGAGGCGACGGCCGCCGCGACGATCCTCAATGCGTGGTTTCCC
GGCGTCGCGACGTGGATATTCGCGCTCGGCATCACGTCGGTGCTCACCGTCACGAATCTCTTCTCGGTCAAGAACTACGG
CGAATTCGAATTCTGGTTCGCGCTCATCAAGGTGGTGGCGATCGTGGTGTTCCTCGCGATCGGCGGCGCGGCGATCGTCG
GCCTGCTGCCGGGTTCGAACGTGTCGGGCGCGGCGCGCCTCGTGAACGCGGGCGGCTTCATGCCGAACGGCGTCGGCGCG
GTGCTCGCCGCGATGCTGACGACGATGTTCTCGTTCCTCGGCACCGAGATCGTCACGATCGCCGCGGCCGAATCCGAGCA
TCCGGAGCGCCAGATCGTCCGCGCGACGAATTCGGTGATCTGGCGCATCTCGCTGTTCTATCTCGGCTCGATCTTCGTCG
TCGCGGCGCTCGTGCCGTGGAACGACGCGCTGCTGCCCGCGCACGGCTCGTATCAGCGCGCGATGGAGCTGATCGGCGTG
CCGCACGCGAAGGGCATCATCGACGTGATCGTGCTGGTGTCGGTTGCGAGCTGCCTGAATTCGGCGCTCTACACGGCGTC
GCGCATGATCTTCTCGCTGTCGACGCGCGGCGACGCGCCGGCATTCTTGCGCCGCACCGATGCAAGCGGCACCCCGCGCG
CGGCGGTGCTCGCGTCGACGGCGTTCGGCTTTCTGACGGTGATCGCGAACTACGTGATGCCCGAGCAGGTGTTCGGCTTC
CTGCTCGCGACGTCGGGCGCGATCGCGCTGCTCGTCTATCTCGTGATCGCGATCTCGCAACTGCGGATGCGCTCGACTCT
CGACGCGACGGGCGAGCGGCTGCCGCTGCGGATGTGGTGCTTTCCGTGGCTCACGTGGGCGGTGATCGTGTTCATCTGCG
GCGTGCTCGTCGTGATGCTGCTGCGCGAGGATCACCGGATGGAAGTCGGCGCGACCGCGGTGCTTGCGCTCGCCGTCGTC
GTCGCATCGCGGATGAACCGGCGCGCGCGCGGCGGCGACGAGCCGACGCCCGCCGCGTCGCGAGTGTCCGCTAACCTGCG
GTGA

Upstream 100 bases:

>100_bases
CGGGTGACGATGACGCGCGTTTTTCGCTGCCGCGGCGTGCGTTTGGACGAGCAGCGAACATCGGCGTGCGGCCGTTGTCC
CGCCCGGCCGGCGGTGCCGT

Downstream 100 bases:

>100_bases
CGCGGCACCGGCGCGCGGCGCGTGACGGCGCCGCTGGCCGCGCCGAACGTGCCGGCCGTGCCGAACGCACGTTACGCGTC
GAGCAGAATCCGTTTATCCG

Product: gaba permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MAVSSKSRGRRAFVDSPSGSIGIRELVLSREPFDAYTASLRRRPITMPTTGAPRCAAAMRGASRTQPRRPAWRTCPGGRR
HDVRSTRGAHCAAHGSITTKPPRRLHAMPGHTGTVFLEGDMEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAE
AGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGA
VLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVIWRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGV
PHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVV
VASRMNRRARGGDEPTPAASRVSANLR

Sequences:

>Translated_587_residues
MAVSSKSRGRRAFVDSPSGSIGIRELVLSREPFDAYTASLRRRPITMPTTGAPRCAAAMRGASRTQPRRPAWRTCPGGRR
HDVRSTRGAHCAAHGSITTKPPRRLHAMPGHTGTVFLEGDMEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAE
AGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGA
VLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVIWRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGV
PHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVV
VASRMNRRARGGDEPTPAASRVSANLR
>Mature_586_residues
AVSSKSRGRRAFVDSPSGSIGIRELVLSREPFDAYTASLRRRPITMPTTGAPRCAAAMRGASRTQPRRPAWRTCPGGRRH
DVRSTRGAHCAAHGSITTKPPRRLHAMPGHTGTVFLEGDMEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEA
GPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPG
VATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGAV
LAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVIWRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVP
HAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGFL
LATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVVV
ASRMNRRARGGDEPTPAASRVSANLR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=446, Percent_Identity=25.5605381165919, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI258645169, Length=378, Percent_Identity=21.6931216931217, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=66.743648960739, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1786789, Length=452, Percent_Identity=36.5044247787611, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI1786302, Length=425, Percent_Identity=37.8823529411765, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI48994972, Length=457, Percent_Identity=35.2297592997812, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87081708, Length=408, Percent_Identity=37.0098039215686, Blast_Score=255, Evalue=7e-69,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=35.3808353808354, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=33.9805825242718, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1790653, Length=444, Percent_Identity=31.981981981982, Blast_Score=245, Evalue=7e-66,
Organism=Escherichia coli, GI1786602, Length=386, Percent_Identity=36.2694300518135, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87081869, Length=262, Percent_Identity=27.0992366412214, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=369, Percent_Identity=22.7642276422764, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=498, Percent_Identity=31.7269076305221, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=557, Percent_Identity=27.8276481149013, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=32.8502415458937, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322892, Length=439, Percent_Identity=33.7129840546697, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324553, Length=404, Percent_Identity=31.9306930693069, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=428, Percent_Identity=31.3084112149533, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=533, Percent_Identity=27.5797373358349, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=419, Percent_Identity=31.5035799522673, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=417, Percent_Identity=30.6954436450839, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=404, Percent_Identity=29.2079207920792, Blast_Score=173, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=442, Percent_Identity=28.5067873303167, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=29.5121951219512, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=448, Percent_Identity=27.9017857142857, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=430, Percent_Identity=29.3023255813954, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=393, Percent_Identity=29.0076335877863, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=32.2335025380711, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=25.3588516746411, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=470, Percent_Identity=22.9787234042553, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667468, Length=345, Percent_Identity=24.9275362318841, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666159, Length=423, Percent_Identity=21.2765957446809, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24668806, Length=409, Percent_Identity=22.2493887530562, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356285, Length=409, Percent_Identity=22.2493887530562, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668802, Length=409, Percent_Identity=22.2493887530562, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221512776, Length=426, Percent_Identity=20.8920187793427, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 62620; Mature: 62489

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSSKSRGRRAFVDSPSGSIGIRELVLSREPFDAYTASLRRRPITMPTTGAPRCAAAMR
CCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHC
GASRTQPRRPAWRTCPGGRRHDVRSTRGAHCAAHGSITTKPPRRLHAMPGHTGTVFLEGD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHCCCCCCCEEEEEECC
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCC
VSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
HHHHHHHHHHHEECCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
AVSSKSRGRRAFVDSPSGSIGIRELVLSREPFDAYTASLRRRPITMPTTGAPRCAAAMR
CCCCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHC
GASRTQPRRPAWRTCPGGRRHDVRSTRGAHCAAHGSITTKPPRRLHAMPGHTGTVFLEGD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHCCCCCCCEEEEEECC
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCC
VSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
HHHHHHHHHHHEECCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]