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The map label for this gene is paaN [H]

Identifier: 237813937

GI number: 237813937

Start: 3592365

End: 3594071

Strand: Direct

Name: paaN [H]

Synonym: GBP346_A3720

Alternate gene names: 237813937

Gene position: 3592365-3594071 (Clockwise)

Preceding gene: 237813935

Following gene: 237813938

Centisome position: 87.65

GC content: 66.26

Gene sequence:

>1707_bases
ATGACCCATCCTCTATTCACGAAGCATGAAGACACGTTGAAGCACGCGCTCTCCACGATCGAAACGCGCGGCTACTGGAG
CCCGTTCGCCGAGATGCCGAGCCCCAAAGTGTACGGGGAAAGCGCCAATACAGACGGCGAAGCAGCATTCAAAACCCAGT
TGGACAAGCCCTTTGAACTCGACCAACCCGCCTCGGGCGGAACGGTCGGCGCCGAGCGTTCGCCATACGGGTTTGCGCTC
GGCGTCCGCTACCCGAAGTCGACGCCCGACGAGCTTATCGCCGCCGCCGCGCAGGCGGAATGCGCGTGGCGCAAGGCCGG
GCCGACCGCGTGGGCTGGCGTGTGTCTCGAAATTCTCGCCCGGCTGAATCGCGCGAGCTTCGAGATCGCATACAGCGTGA
TGCACACCACGGGACAAGCGTTCATGATGGCGTTCCAGGCGGGCGGCCCGCACGCGCAGGATCGCGCGCTCGAAGCCGTC
GCCTATGCATGGCAAGAACTGCAGCGCATTCCCGCCGAAGCGCACTGGGAGAAGCCGCAGGGCAAGAACCCGCCGCTCGC
GATGCACAAGCGCTACACGATCGTGCCGCGCGGGACGGGGCTCGTGCTCGGGTGCTGCACGTTCCCGACCTGGAACGGCT
ATCCCGGTCTGTTCGCCGATCTGGCGACCGGCAACACAGTCATCGTCAAGCCGCATCCCGGCGCGATCCTGCCGCTCGCG
ATCACCGTGCGCATCGCGCGCGACGTGCTGCGCGAAGCGGGCTTCGATCCGAACATCGTCACGCTGCTCGCGACCGAAGG
AAACGACGGCGCACTCGTCCAGGATCTGGCGCGCCGGCCGGAAATCAAGCTGATCGACTTCACCGGCAGCTCGCAAAACG
GCACCTGGCTCGAGCGCAATGCGTACCAGGCGCAGGTCTATACGGAGAAGGCGGGCGTCAACCAGATCGTGATCGACTCC
GTCGACGACCTGAAAGCCGCCGTCAAGAACATCGCGTTCTCGCTTGCGCTCTACTCCGGCCAGATGTGCACAGCGCCGCA
AAACATCTATGTGCCGCGTGACGGCATCCGCACCGCCGAAGGGCACGTCGGCTTCGACGACGTCGCGCGGGCGATCGCCG
ACGCCGTGCAAAAGCTGACGGGCGACCCGGCACGCTCGGTCGAACTCATCGGGGCGCTGCAGAACGCAGGCGTCGCGGCA
CGTATCGACGAAGCGCGCAAGCTCGGCCGCATTCTCGCCGACAGCCAGGCGCTCGAGCACCCGGCATTCAAGGACGCGCG
CGTGCGCACGCCGCTCGTGCTGCAACTCGACGTCACGGACCGTGCGAAGTACACGCAGGAATGGTTCGGTCCGATCTCGT
TCGTCATCGCGACCGATTCGACTGCGCAATCGCTCGATCTCGCCGGCTCGATCGCGGCCGAGCATGGTGCGCTCACGCTG
TCCGTCTATAGCACGGACGACGCCGTCGTCGAAGCGGCGCACGAAGCGGCGGTGCGCGGCGGCGTCGCGCTGTCGATCAA
TCTGACGGGCGGCGTGTTCGTCAATCAGTCGGCGGCGTTCTCCGACTTTCACGGCACGGGCGCCAATCCGGCCGCGAATG
CGTCGCTCGCCGACGCCGCGTTCGTCGCGAACCGCTTCCGCGTCGTTCAGAGCCGCCACCATGTTGCGCCGAAGGCGGCT
CCCGCGGAAGCCGGCCAAACGGCATAA

Upstream 100 bases:

>100_bases
TGCCGCACACGCACGGATGATTTGATGCTAACATTTTCCGACCAACCGGTCGGTTAATTAATGACCATCGCTTCCCTCAA
CGCTCACCAAGCCTGCCGCC

Downstream 100 bases:

>100_bases
CCCGTTCGGCCGAGCTGTCGATCGCGCGACCGTTCACTACCATGAATGAACCCGCCCGCTCGCGGGTTCACCTTTGCCGG
AATTCGACATGACCGAAGCA

Product: phenylacetic acid degradation protein PaaN

Products: NA

Alternate protein names: P5C dehydrogenase [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKTQLDKPFELDQPASGGTVGAERSPYGFAL
GVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAV
AYAWQELQRIPAEAHWEKPQGKNPPLAMHKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDS
VDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAA
RIDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVTDRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAA
PAEAGQTA

Sequences:

>Translated_568_residues
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKTQLDKPFELDQPASGGTVGAERSPYGFAL
GVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAV
AYAWQELQRIPAEAHWEKPQGKNPPLAMHKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDS
VDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAA
RIDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVTDRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAA
PAEAGQTA
>Mature_567_residues
THPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKTQLDKPFELDQPASGGTVGAERSPYGFALG
VRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVA
YAWQELQRIPAEAHWEKPQGKNPPLAMHKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLAI
TVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDSV
DDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAAR
IDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVTDRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTLS
VYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAAP
AEAGQTA

Specific function: Oxidizes Proline To Glutamate For Use As A Carbon And Nitrogen Source And Also Function As A Transcriptional Repressor Of The Put Operon. [C]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family. RocA subfamily [H]

Homologues:

Organism=Homo sapiens, GI115387104, Length=287, Percent_Identity=24.7386759581882, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1787250, Length=369, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787684, Length=276, Percent_Identity=26.4492753623188, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551164, Length=285, Percent_Identity=25.9649122807018, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534176, Length=305, Percent_Identity=24.9180327868852, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321828, Length=342, Percent_Identity=26.0233918128655, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=191, Percent_Identity=31.413612565445, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR005932 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.5.1.12 [H]

Molecular weight: Translated: 60646; Mature: 60515

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKTQLDKPFEL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCCCCCCCHHHHHHCCCCCCC
DQPASGGTVGAERSPYGFALGVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILA
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWQELQRIPAEAHWEKPQ
HHCCCHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
GKNPPLAMHKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
CCCCCEEECCEEEEEECCCCEEEEEECCCCCCCCCCHHHECCCCCEEEECCCCCCEEHHH
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERN
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECC
AYQAQVYTEKAGVNQIVIDSVDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAE
CEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHEECCCEECCCCCEEECCCCCCCCC
GHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAARIDEARKLGRILADSQALEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHCC
PAFKDARVRTPLVLQLDVTDRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
CCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEE
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAA
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
FVANRFRVVQSRHHVAPKAAPAEAGQTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKTQLDKPFEL
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCCCCCCCHHHHHHCCCCCCC
DQPASGGTVGAERSPYGFALGVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILA
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWQELQRIPAEAHWEKPQ
HHCCCHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
GKNPPLAMHKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
CCCCCEEECCEEEEEECCCCEEEEEECCCCCCCCCCHHHECCCCCEEEECCCCCCEEHHH
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERN
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECC
AYQAQVYTEKAGVNQIVIDSVDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAE
CEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHEECCCEECCCCCEEECCCCCCCCC
GHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAARIDEARKLGRILADSQALEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHCC
PAFKDARVRTPLVLQLDVTDRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
CCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEE
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAA
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
FVANRFRVVQSRHHVAPKAAPAEAGQTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA