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The map label for this gene is maeB [H]

Identifier: 237813842

GI number: 237813842

Start: 3494002

End: 3496311

Strand: Reverse

Name: maeB [H]

Synonym: GBP346_A3620

Alternate gene names: 237813842

Gene position: 3496311-3494002 (Counterclockwise)

Preceding gene: 237813846

Following gene: 237813841

Centisome position: 85.31

GC content: 65.37

Gene sequence:

>2310_bases
ATGTCGACCTCGTCCTCCTCCTCTTCCTCGAAAGAAAAACTCCGCGAAGCCGCTCTCGATTACCACGAATTCCCGACACC
GGGCAAAGTCGCGATCGCGCCGACCAAACAGATGATCAATCAGCGCGATCTCGCGCTCGCCTATTCGCCGGGCGTCGCGT
TCGCGTGCGAGGAGATCGTCGAGAACCCGTTGAACGCCGCGCGCTTCACCGCGCGCAGCAACCTCGTCGGCGTCGTCACG
AACGGCACCGCGGTGCTCGGCCTCGGCAACATCGGCCCGCTCGCGTCGAAGCCGGTGATGGAAGGCAAGGCGGTCCTCTT
CAAGAAGTTCGCCGGGATCGACGTGTTCGACATCGAGCTCAACGAATCCGATCCGCACAAGCTCGTCGACGTGATCGCCG
CGCTCGAACCGACGTTCGGTGGGATCAACCTCGAGGACATCAAGGCGCCGGACTGCTTCATCGTCGAGCGCGAATGCCGC
AAGCGAATGAAGATTCCGGTGTTCCACGACGACCAGCACGGCACCGCGATCGTCGTCGCGGCCGCGGTCACCAACGGGCT
GAAGGTGGTCGGCAAGAGCATCAAGGAAGTGAAGCTCGTTGCGTCGGGCGCGGGCGCGGCCGCGCTCGCGTGCCTCGATT
TGCTCGTCGATCTCGGCTTGCCGCTCGAGCACATCACGGTGACCGATCTGGCGGGCGTCGTCTACAAGGGCCGTGCGGAG
CTGATGGACCCGGACAAGGAGCGTTTCGCGCGCGAAACCGATGCGCGCACGCTGTCGGAGGTGATCGACGGCGCGGACAT
CTTCCTCGGCCTGTCGGCGGCCGGCGTGCTGAAGGCCGACATGGTGAAGAAGATGGCCGAGCGCCCGCTGATTCTCGCGC
TCGCGAATCCGACCCCGGAAATCCTGCCGGAAGTGGCGCTGGAGGCGCGGCCGGACGCCGTGCTCGCGACGGGCCGCACC
GATTATCCGAACCAGGTCAACAACGTCCTGTGCTTCCCGTTCATCTTCCGTGGCGCGCTCGATGTCGGCGCGACGACGAT
CACCCGCGAGATGGAGATCGCCGCCGTCAACGCGATCGCCGAGCTCGCGCAGCAGGAGCAAAGCGACATCGTCGCGACCG
CGTATGGCATTCAGGATCTCTCGTTCGGGCCCGAATATCTGATTCCGAAGCCGTTCGATCCGCGCCTCATCGTGAAGATC
GCGCCCGCGGTCGCGCAGGCGGCGATGGACGGCGGTGTGGCGACCCGTCCGATCGAGGACATGGAAGCGTACAAGGTTCA
CCTGCAGCAGTTCGTCTACCACAGCGGCACGACGATGAAGCCGGTGTTCCAGATCGCGCGCGGCGCGCCCGCCGAGAAGA
AGCGGGTGGTGTTCGCGGAGGGCGAGGAAGAGCGCGTGCTGCGCGCGGTGCAGATCGTCGTCGACGAGAAGCTCGCGAAG
CCGATCCTGATCGGGCGGCCCGCCGTGATCGAGCACCGGATCCAGCGCTACGGCCTGCGGCTCACGCCGGGTGTCGATTT
CACGATCGTCAACACCGAGCACGACGAGCGTTACCGCGATTTCTGGCAAACCTACTTCAAGATGATGGCCCGCAAGGGGA
TCAGCGAGCAGCTCGCGCGCGTCGAAATGCGCCGCCGCACGACGCTGATCGGCTCGATGCTCGTCAAGAAGGGCGAGGCG
GACGGGATGATTTGCGGCACGATCAGCACGACGCACCGCCACCTGCACTTCATCGATCAGGTGATCGGCAAGCGCGCCGG
CTGCAGCGTATACGGCGCGATGAACGCGCTGGTGCTGCCCGGCCGGCAGATTTTCCTGGTCGACACGCACGTGAACGTCG
ATCCGACCCCGGCGCAGCTCGCCGAGATCACGATCATGGCGGCGGAAGAGGTGCGCCGCTTCGGCATCGAGCCGAAGGTC
GCGCTGCTGTCGCATTCGAACTTCGGCACGAGCAACGCGCCTTCCGCGCAGAAGATGCGCGATACGCTCGCGATCCTGCA
AGAACGCGCGCCCGATCTGCATGTCGACGGCGAGATGCACGGCGACGTCGCGCTCGACGCGGCGTTGCGCAAGGAGATCC
TGCCCGAATCGACGCTCGAGGGCGAAGCGAACCTGCTCGTGCTGCCGAACATCGATGCCGCGAACATCGCCTACAACCTG
CTCAAAACGGCTGCCGGCAACAACATCGCGATCGGGCCGATTCTGCTCGGCGCCGCGCAGCCCGTGCACGTGCTGACCGA
ATCGGCGACCGTGCGCCGGATCGTCAACATGACGGCGCTGCTGGTTGCCGACGTGAACGCGGTACGTTGA

Upstream 100 bases:

>100_bases
GGTCGCGGCTGTCAAACCCTAATCGGCGATTTTGCGTGTGGGATTGGCGCTACAATGCGTCGAACAGGTATTCTAATCCG
CAGACCCCCCGTAGAGACAC

Downstream 100 bases:

>100_bases
GCGAAGTTATCGGGCGATAAAAAAACGGCGCGCCCGTTGCGGGCGCGCCGTCGGGCATGGCGGAGAAAAGCGCCTTCCCG
AAGCCGACGACGCCACCCTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MSTSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFTARSNLVGVVT
NGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECR
KRMKIPVFHDDQHGTAIVVAAAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAE
LMDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPEILPEVALEARPDAVLATGRT
DYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKI
APAVAQAAMDGGVATRPIEDMEAYKVHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAK
PILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEA
DGMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLPGRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKV
ALLSHSNFGTSNAPSAQKMRDTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNL
LKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR

Sequences:

>Translated_769_residues
MSTSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFTARSNLVGVVT
NGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECR
KRMKIPVFHDDQHGTAIVVAAAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAE
LMDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPEILPEVALEARPDAVLATGRT
DYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKI
APAVAQAAMDGGVATRPIEDMEAYKVHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAK
PILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEA
DGMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLPGRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKV
ALLSHSNFGTSNAPSAQKMRDTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNL
LKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR
>Mature_768_residues
STSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFTARSNLVGVVTN
GTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRK
RMKIPVFHDDQHGTAIVVAAAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAEL
MDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPEILPEVALEARPDAVLATGRTD
YPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIA
PAVAQAAMDGGVATRPIEDMEAYKVHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAKP
ILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEAD
GMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLPGRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKVA
LLSHSNFGTSNAPSAQKMRDTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNLL
KTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=345, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=28.6931818181818, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=28.6931818181818, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=28.6931818181818, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4505145, Length=419, Percent_Identity=27.4463007159904, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI270265879, Length=368, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788806, Length=754, Percent_Identity=61.8037135278515, Blast_Score=968, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=319, Percent_Identity=32.9153605015674, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788800, Length=326, Percent_Identity=31.5950920245399, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537199, Length=464, Percent_Identity=25.6465517241379, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=29.7071129707113, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356279, Length=484, Percent_Identity=25.4132231404959, Blast_Score=90, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281362674, Length=484, Percent_Identity=25.4132231404959, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281362672, Length=484, Percent_Identity=25.4132231404959, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI78707242, Length=408, Percent_Identity=25.9803921568627, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707238, Length=408, Percent_Identity=25.9803921568627, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=26.3610315186246, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83206; Mature: 83075

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIV
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHCCCCCEEEEECCCHHHHHHHHH
ENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIEL
HCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEE
NESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVA
CCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEE
AAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAE
EHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHEEHHHHHHHHCCCCHH
LMDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPE
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHH
ILPEVALEARPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIA
HHHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIED
HHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCHHH
MEAYKVHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
PILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLAR
CEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHH
VEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLP
HHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEC
GRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAQKMR
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHH
DTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNL
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHH
LKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR
HHHCCCCCEEECCEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHCCCCCEEEEECCCHHHHHHHHH
ENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIEL
HCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEE
NESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVA
CCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEE
AAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAE
EHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHEEHHHHHHHHCCCCHH
LMDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPE
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHH
ILPEVALEARPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIA
HHHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIED
HHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCHHH
MEAYKVHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
PILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLAR
CEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHH
VEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLP
HHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEC
GRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAQKMR
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHH
DTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNL
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHH
LKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR
HHHCCCCCEEECCEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]