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The map label for this gene is hexR [H]

Identifier: 237813811

GI number: 237813811

Start: 3466611

End: 3467609

Strand: Direct

Name: hexR [H]

Synonym: GBP346_A3589

Alternate gene names: 237813811

Gene position: 3466611-3467609 (Clockwise)

Preceding gene: 237813810

Following gene: 237813812

Centisome position: 84.58

GC content: 70.37

Gene sequence:

>999_bases
ATGCTCCCCCGTATCGAGACGATCCGCGCCCAGCTCCGCCCGTCCGAGCGCAAGCTCGCCGATTTCGTGCTCGCCGCGCC
GCGCGAGGTGCTCGATCTGTCGATGACCGAGCTCGCCGCGCGCGCGGGCGCGAGCCAGCCGACGATCGCGCGCTTTTGCC
AGGCGCTCGGTTGCAGCGGCTTTCGCGAGTTCAAGATCCGTCTCGCGCAGAGCGTCGCGCCGGGTGTCGCGTCGGTGTAT
CGCGACGTCGAGCCCGACGAGCGCGCACCGGGCATCATCGGCAAGGTGTTCGACCGCACGATCGGCGCGCTGATCGAGGT
GCGCAACAGCCTGTCGGCGACGAGCGTCGCCGAGGCGATCGAGCTGCTCACGCGCGCGTCGCGCATCGAGTTCTACGGCG
CGGGCGGCTCGGGCATCGCCGCGCAGGACATCCAGCACAAGTTCTTCCGGCTCGGCGTGCCGAGCGTCGCGTACTCGGAC
CCGCACACATTCTCGATGTCGGCCGCGCTCCTCGGCGCGAACGACGTCGTCGTCGCGATCTCGAACACGGGGCGCACGCG
CGACATCGTCGACGCCGCGCGCGCGGCGCTCGCGTGCGACGCGAAGGTGATCTCGATCACGCACAGCCATTCGCCGCTCG
CGCAACTTTCGACGGTGAGCCTCGCATCGAACGTCGCCGAGGAAACCGACGTGTTCTCGCCGATGACGTCGCGCATGTCG
CATCTCGCGATCGGCGACATCCTCGCGGTCGGTGTCGCGCTGCGGCGCGGCCCCGAACTCGTCGACCGGCTCGGCCGCGC
GAAGGAGGCGATCACGCGGCGGCGGATCGGCGCCGATGCGAAGGCGCAGAAGGAAACGGGAAAGGACGCGACAAAGGTCG
CGGCGAGCGGCGTGGCGGGCGGCGCGGCGGAAAGTGCGCAGCAAGCCGCGCGCGCGCAGGCGCCGCAAGTGGGGGAGAAA
ACGCGGATCGCGCGCGACATCGAGGACGTGAAGGATTAG

Upstream 100 bases:

>100_bases
GATCGATATCGGGAAATTCGCTAGAAAATACTTGTAGATTTTCTACAAAACTATCGCGATACTAGCGTCCGTCCTGTCAT
TGCACGCGCCCTTTCGCACC

Downstream 100 bases:

>100_bases
CGGGCGGTTGAAACGCGCCAGCGAGTGCCGCCGCGGGAACCGGCCGCTCTCGCGACACGCGCCGTGAGCCGCTCACCCCG
GCCACGGTGACGGTTGGACG

Product: HTH-type transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSGFREFKIRLAQSVAPGVASVY
RDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSD
PHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACDAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMS
HLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAGGAAESAQQAARAQAPQVGEK
TRIARDIEDVKD

Sequences:

>Translated_332_residues
MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSGFREFKIRLAQSVAPGVASVY
RDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSD
PHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACDAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMS
HLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAGGAAESAQQAARAQAPQVGEK
TRIARDIEDVKD
>Mature_332_residues
MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSGFREFKIRLAQSVAPGVASVY
RDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSD
PHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACDAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMS
HLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAGGAAESAQQAARAQAPQVGEK
TRIARDIEDVKD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=277, Percent_Identity=40.7942238267148, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI87082369, Length=252, Percent_Identity=29.3650793650794, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788767, Length=281, Percent_Identity=27.4021352313167, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87082130, Length=211, Percent_Identity=30.8056872037915, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 35066; Mature: 35066

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSG
CCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
FREFKIRLAQSVAPGVASVYRDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAI
HHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSDPHTFSMSAALLGANDVVVAI
HHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEE
SNTGRTRDIVDAARAALACDAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMS
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCC
GAAESAQQAARAQAPQVGEKTRIARDIEDVKD
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSG
CCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
FREFKIRLAQSVAPGVASVYRDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAI
HHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSDPHTFSMSAALLGANDVVVAI
HHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEE
SNTGRTRDIVDAARAALACDAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMS
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHCCCC
GAAESAQQAARAQAPQVGEKTRIARDIEDVKD
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]