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The map label for this gene is groEL [H]

Identifier: 237813791

GI number: 237813791

Start: 3448832

End: 3450451

Strand: Direct

Name: groEL [H]

Synonym: GBP346_A3569

Alternate gene names: 237813791

Gene position: 3448832-3450451 (Clockwise)

Preceding gene: 237813790

Following gene: 237813792

Centisome position: 84.15

GC content: 66.17

Gene sequence:

>1620_bases
ATGCGTGCAAAGGACGTCAAGTTCCATGAAGGCGCCCGCGCCCATATCGTCAAGGGTGTCAATGTCCTCGCCGACGCGGT
GAAGGTGACGCTCGGCCCGAAAGGCCGCAACGTGCTGATCGAGCGCAGCTTCGGCGCGCCGACCATCACGAAGGACGGCG
TATCCGTCGCAAAGGAAATCGAACTGCAGGACCGCTTCGAGAACATGGGCGCGCAGATCGTCAAGCAGGTCGCGTCCAAG
ACCGCCGACGTCGCCGGCGACGGCACCACCACCGCGACCGTGCTCGCGCAGGCGATCGTGCAGGAAGGCATGAAGCACGT
CGCGGCGGGCGTGAACCCGATGGATCTGAAGCGAGGCATCGATAAGGCGGTGGCCGCCGTGATCGACGAGTTGCGCAAGC
TGTCGAAGCCTATCTCGACAAACAAGGAAATCGCGCAGGTTGCCTCCATTTCCGCGAATGCCGACGAAGCGATCGGCAAG
ATCATTGCCGACGCGATGGAGAAAGTCGGCAAGGAAGGCGTCATCACGGTCGAGGACGGCAAATCGCTGGAGAACGCGCT
CGACGTCGTCGAAGGCCTGCAATTCGACCGCGGCTACGCGAGCCCGTACTTCATCAACGATCCGGACAAGCAGGCCGCCT
ATCTCGACGACGCGCTGATCCTGCTGCACGACAAGAAGATCTCGGCCGTGCGGGACCTGCTGCCCATCCTCGAAGCGGCG
ACGCAGGCAGGCAAGCCGTTGCTGATCGTCGCCGAGGACATCGAAGGCGAGGCGCTCGCGACGCTCGTCGTCAACGCGAT
GCGCGGAGCGCTGAAAGTAGCCGCCGTCAAGGCGCCCGGCTTCGGCGACCGACGCCGCGCGATGCTCGAGGACATCGCGA
TTCTCACCGGAGCGACGGTCGTCTCGGAGGAGACCGGCAAGCAGCTCGCGAAGGCGACGCTCGAGGAGCTCGGCAGCGCG
AAGCGTATCGAGGTGCGCAAGGACGACACCATCATCGTCGGCGGCGCGGGCGACGCGAAACGCATCGAAGCGCGCGTGAA
AGCGATCCGCTTGCAGATCGACGAAGCGACGAGCGACTACGATCGCGAAAAGCTTCAGGAACGCGTCGCGAAACTCGCGG
GCGGCGTCGCGGTGATCAAGGTGGGCGCCGCGACCGAAGTCGAGATGAAGGAGAAGAAGGACCGCGTCGACGACGCGCTG
CACGCCACGCGCGCGGCCGTCGACGAAGGAATCGTGCCCGGCGGCGGCGTCGCGCTGCTGCGCGCGCGAACGGCGGTGTC
GAGCCTCAAGGGCGCGAACGCGGATCAGGACGCCGGCGTGCGCATCGCGCTGCGCGCGCTGGAAGCGCCGCTACGCGTGA
TCGCGACGAACGCGGGCGACGAGCCGTCGGTCGTGATCGCGAAAGTGCTGCAAGGCCAGGGCAACTTCGGCTATAACGCC
GCCACGGGCGAATACGGCGACCTCGTCGACATGGGCGTCGTCGATCCGACCAAGGTGACGCGCACGGCGTTGCAGAACGC
GGCGTCGGTCGCCGGGCTGATTCTCACGACGGACGCGACAGTGGCCGACGCGCCGAAGGAAGACAAGCCCGCGCCCAAGA
CCGCTCCGGAACTCGGCTAG

Upstream 100 bases:

>100_bases
CGCCGCAGCCCGTGACCGGCCGCGAACGCCGCGCGGCGCAGCGCCGTGCCCGCTCGCGGCCGGATCGAGTCAACGATTCT
TCCCTCAGGAGCAACACGCC

Downstream 100 bases:

>100_bases
CGATCCGGCGCGCCTTCGTGCCGCCCGCTGCGGCCGACTTGCGCCGGCCGCAGCGGCTGCCGTTCGGCGCCGTGCGCGTC
GCGCGTACGGCACGGCGTGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MRAKDVKFHEGARAHIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELQDRFENMGAQIVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGVNPMDLKRGIDKAVAAVIDELRKLSKPISTNKEIAQVASISANADEAIGK
IIADAMEKVGKEGVITVEDGKSLENALDVVEGLQFDRGYASPYFINDPDKQAAYLDDALILLHDKKISAVRDLLPILEAA
TQAGKPLLIVAEDIEGEALATLVVNAMRGALKVAAVKAPGFGDRRRAMLEDIAILTGATVVSEETGKQLAKATLEELGSA
KRIEVRKDDTIIVGGAGDAKRIEARVKAIRLQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVDEGIVPGGGVALLRARTAVSSLKGANADQDAGVRIALRALEAPLRVIATNAGDEPSVVIAKVLQGQGNFGYNA
ATGEYGDLVDMGVVDPTKVTRTALQNAASVAGLILTTDATVADAPKEDKPAPKTAPELG

Sequences:

>Translated_539_residues
MRAKDVKFHEGARAHIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELQDRFENMGAQIVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGVNPMDLKRGIDKAVAAVIDELRKLSKPISTNKEIAQVASISANADEAIGK
IIADAMEKVGKEGVITVEDGKSLENALDVVEGLQFDRGYASPYFINDPDKQAAYLDDALILLHDKKISAVRDLLPILEAA
TQAGKPLLIVAEDIEGEALATLVVNAMRGALKVAAVKAPGFGDRRRAMLEDIAILTGATVVSEETGKQLAKATLEELGSA
KRIEVRKDDTIIVGGAGDAKRIEARVKAIRLQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVDEGIVPGGGVALLRARTAVSSLKGANADQDAGVRIALRALEAPLRVIATNAGDEPSVVIAKVLQGQGNFGYNA
ATGEYGDLVDMGVVDPTKVTRTALQNAASVAGLILTTDATVADAPKEDKPAPKTAPELG
>Mature_539_residues
MRAKDVKFHEGARAHIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELQDRFENMGAQIVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGVNPMDLKRGIDKAVAAVIDELRKLSKPISTNKEIAQVASISANADEAIGK
IIADAMEKVGKEGVITVEDGKSLENALDVVEGLQFDRGYASPYFINDPDKQAAYLDDALILLHDKKISAVRDLLPILEAA
TQAGKPLLIVAEDIEGEALATLVVNAMRGALKVAAVKAPGFGDRRRAMLEDIAILTGATVVSEETGKQLAKATLEELGSA
KRIEVRKDDTIIVGGAGDAKRIEARVKAIRLQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVDEGIVPGGGVALLRARTAVSSLKGANADQDAGVRIALRALEAPLRVIATNAGDEPSVVIAKVLQGQGNFGYNA
ATGEYGDLVDMGVVDPTKVTRTALQNAASVAGLILTTDATVADAPKEDKPAPKTAPELG

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.219696969697, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.219696969697, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI5453607, Length=544, Percent_Identity=22.6102941176471, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=70.4545454545455, Blast_Score=751, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.1739130434783, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=53.0805687203791, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17564182, Length=561, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532603, Length=543, Percent_Identity=22.4677716390424, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566944, Length=235, Percent_Identity=26.3829787234043, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.8167938931298, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=573, Percent_Identity=22.6876090750436, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.5104364326376, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.5104364326376, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.6129032258064, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.6129032258064, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.6129032258064, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=45.0943396226415, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=39.9253731343284, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=39.9253731343284, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56487; Mature: 56487

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKDVKFHEGARAHIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELQDRFENMGAQIVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGVNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVIDELRKLSKPISTNKEIAQVASISANADEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
KSLENALDVVEGLQFDRGYASPYFINDPDKQAAYLDDALILLHDKKISAVRDLLPILEAA
CHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
TQAGKPLLIVAEDIEGEALATLVVNAMRGALKVAAVKAPGFGDRRRAMLEDIAILTGATV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCHH
VSEETGKQLAKATLEELGSAKRIEVRKDDTIIVGGAGDAKRIEARVKAIRLQIDEATSDY
HHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHEEECCCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVDEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RARTAVSSLKGANADQDAGVRIALRALEAPLRVIATNAGDEPSVVIAKVLQGQGNFGYNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHCCCCCCCCC
ATGEYGDLVDMGVVDPTKVTRTALQNAASVAGLILTTDATVADAPKEDKPAPKTAPELG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAKDVKFHEGARAHIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELQDRFENMGAQIVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGVNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVIDELRKLSKPISTNKEIAQVASISANADEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
KSLENALDVVEGLQFDRGYASPYFINDPDKQAAYLDDALILLHDKKISAVRDLLPILEAA
CHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
TQAGKPLLIVAEDIEGEALATLVVNAMRGALKVAAVKAPGFGDRRRAMLEDIAILTGATV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCHH
VSEETGKQLAKATLEELGSAKRIEVRKDDTIIVGGAGDAKRIEARVKAIRLQIDEATSDY
HHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHEEECCCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVDEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RARTAVSSLKGANADQDAGVRIALRALEAPLRVIATNAGDEPSVVIAKVLQGQGNFGYNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHCCCCCCCCC
ATGEYGDLVDMGVVDPTKVTRTALQNAASVAGLILTTDATVADAPKEDKPAPKTAPELG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA