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The map label for this gene is ubiH [H]

Identifier: 237813758

GI number: 237813758

Start: 3421927

End: 3423168

Strand: Direct

Name: ubiH [H]

Synonym: GBP346_A3535

Alternate gene names: 237813758

Gene position: 3421927-3423168 (Clockwise)

Preceding gene: 237813757

Following gene: 237813759

Centisome position: 83.49

GC content: 74.24

Gene sequence:

>1242_bases
GTGATCCGCGCGCCCCTTCTTTCCACCGAGACTCACGATTCACGAACGATGACGACCGCCGCCTCCACGCCCGCTTTCGA
CTTCGACATCGCGATCGTCGGCGCCGGGCCGGTCGGGCTCGCGCTCGCCGGCTGGCTCGCGCGCCGCAGCGCGACCCGCG
CGCTGTCGGTCGCGCTCGTCGACGCGCGGGACCCCGACGCGAGCGAGAACGACCCGCGCGCGATCGCGGTATCGCAAGGC
AGCCGGATGCTGCTCGACACGCTCGGCTGGCCGGGCGACGCCACGCCGATCGAGCACATCCACGTCTCGCAACGCGGCCA
CTTCGGCCGCACGCTGATCGAGCGCGACGAGCACGACCTTGCCGCGCTCGGCTATGTCGCGCGCTACGGCTCGATCGTGC
GGGCGCTCGCGCGCGCGGTGCGCGGCACGCCCGCGCGCTGGCTCACGTCGACGTCCGCCCATTCGCCGGCGCAGGACGCC
GACGGCGTGACCATCGCGCTCGACACGCCGCAGGGCGCGCGCACGCTGCGCGCGCGCGTGCTCGTCAACGCGGAGGGCGG
CCTCTTCGACGAGCGCAAGCGCAAGCTGACCGACAGCGCGACGAACCGCGACTACGGGCAGACGGCGCTCGTCGGCACCG
TCACGGTGTCCGCGCCGCGCCCGCGCGTCGCGTGGGAGCGCTTCACCGCCGAAGGCCCGCTCGCGCTGCTGCCGCTCGGC
GGCCCGCAGCAGGCGGACTACGCGCTCGTCTGGTGCTGCGCGCCGGACGTCGCGCAACGCCGCGGCGCGCTGCCCGACGA
TGCGTTCCTGCAGGAGCTCGGCGCGACGTTCGGCACGCGGATGGGGCGCTTCACGCGGATCGTCGGGCGCGCGGCGTTCC
CGCTCGGGCTCGCCGCGGCACACACGCTCGTCGAAGGCCGGATCGCGATCGTCGGCAACGCCGCGCAAACCTTGCATCCG
GTCGCGGGCCAGGGGCTGAACCTCGGGCTGCGCGACGCGCATACGCTTGCCGAGACGCTGTCCGAGCACGGCGCGACGCC
GCTCGCGCTCGCGACGTTCAACGCGCGCCGCGCGCTCGATCGGCGCATGACGATCGGCGCGACCGATACGCTCGCGCGCC
TGTTCACCGTCGATTCGCGGCCGCTCGCGATGCTGCGCGGCGCGGCGCTCACCGCGCTCGAATTCGTGCCGCCGCTGAAG
ACGGCGATCGCGCGACAGATGATGTTCGGGCAGCGGCGCTAG

Upstream 100 bases:

>100_bases
CGCCGACGGGATGCGAGCTGATCACGCGCGGCGTGCCGGTGGCGGCCGACGAGATCGAGGCATTGATGCGCGACGCGCGG
CCGGCGCCGCGCCCGCAGCC

Downstream 100 bases:

>100_bases
GCGCGCCGCAGGCGCACGCCGATGCGCGGCGGCTACCGCGCCTCGCGGGTACGCACGATGCGTCACCCCACCTTCACGCA
AGATTCATCGACGATTTGAC

Product: hypothetical protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MIRAPLLSTETHDSRTMTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQG
SRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDA
DGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLG
GPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHP
VAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLK
TAIARQMMFGQRR

Sequences:

>Translated_413_residues
MIRAPLLSTETHDSRTMTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQG
SRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDA
DGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLG
GPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHP
VAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLK
TAIARQMMFGQRR
>Mature_413_residues
MIRAPLLSTETHDSRTMTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQG
SRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDA
DGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLG
GPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHP
VAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLK
TAIARQMMFGQRR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=397, Percent_Identity=26.448362720403, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI32967307, Length=348, Percent_Identity=26.7241379310345, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789274, Length=405, Percent_Identity=34.320987654321, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789273, Length=395, Percent_Identity=29.873417721519, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786883, Length=383, Percent_Identity=28.1984334203655, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321694, Length=470, Percent_Identity=23.4042553191489, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19920760, Length=452, Percent_Identity=26.7699115044248, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 44016; Mature: 44016

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRAPLLSTETHDSRTMTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALV
CCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEE
DARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDL
ECCCCCCCCCCCCEEEECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHH
AALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLRARV
HHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
LVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLG
EEECCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEECC
GPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAA
CCCCCCEEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
HTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALD
HHHHCCCEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
RRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
HHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRAPLLSTETHDSRTMTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALV
CCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEE
DARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDL
ECCCCCCCCCCCCEEEECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHH
AALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLRARV
HHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
LVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLG
EEECCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCEEEEECC
GPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAA
CCCCCCEEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
HTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALD
HHHHCCCEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
RRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
HHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]