Click here to switch to the map view.

The map label for this gene is pepP [H]

Identifier: 237813757

GI number: 237813757

Start: 3420521

End: 3421930

Strand: Direct

Name: pepP [H]

Synonym: GBP346_A3534

Alternate gene names: 237813757

Gene position: 3420521-3421930 (Clockwise)

Preceding gene: 237813754

Following gene: 237813758

Centisome position: 83.46

GC content: 72.2

Gene sequence:

>1410_bases
GTGATGAATCAGCCGACCGAACCCGCCATCGCCCTCGACGTCTACCGCCAGCGCCGCGACCGCGTGCTGGCCTCGCTGCG
CGCGCAAGGCGGCGGCGTCGCGATCGTGCCCACCGCACCGGAAGTCCCGCGCAATCGCGACAGCGACTATCCGTACCGGC
ACGACAGCTACTTCTACTACCTGACGGGCTTCGCCGAGCCCGACGCGCTGCTCGTCCTCGACGCGTCGGCGGCCGGCGAC
GCGCCGCGCTCGATCCTGTTCTGCCGCGCGAAGAATCCCGAGCGAGAAATCTGGGAAGGGTTCCATTTCGGGCCCGAAGG
CGCGCGCGATGCGTTCGGCTTCGACGCCGCGTTCCCGTACGACGCGCTCGATGCCGAAATGCCGCGCATCGTCGCCGACG
CGCCCGCGCTCCACTACCGCTTCGGCGTGTCGGCCGCTTTCGACGCGCGCCTGAACGGCTGGCTCGACGCGGTGCGCGCG
CGTGCGCGCGCCGGCGTCGCCGCGCCGGGCGCCGCGTTCGATCTCGGGCCGCTCCTCGATGACATGCGGCTCGTCAAGGA
TGCGCACGAGCAGGCAACGATGCGCCGCGCGGCCGACATCTCCGCGCTCGCACACCGCCGCGCGATGGCCGCGTGCCGCC
CCGGCATCCGCGAATACGAACTCGAGGCCGAGCTGCTCTACACGTTCCGCCGCCACGGCGCGCAATCGCCCGCATACGGC
TCGATCGTCGCGACGGGCGCGAACGCATGCGTGCTCCACTATCCGGCCGGCAACGCCGTCGTCGCCGACGGCGAGCTCGT
GCTGATCGACGCCGCGTGCGAGCTCGACGGCTACGCATCCGACATCACCCGCACGTTTCCGGCGAACGGCCGCTTCTCGG
GCCCGCAACGCGCGCTTTATGACATCGTGCTCGCCGCTCAGGAAGCGGCGATCGCGGCGACGCGCGCCGGCACGCCGTTC
GACGCGCCGCACGACGCGGCGGTGCGCGTGCTCGCGCAGGGCATGCTCGACACGGGGCTCGTGCCGAAGACGCGCTTCGC
GAGCGTCGACGACGTGATCGCCGAGCGTGCGTACACGCGCTTCTACATGCACCGCACCGGCCACTGGCTCGGCATGGACG
TGCACGACTGCGGCGACTACCGCGAGCGCGCCGCGCCGCGCGACGACGACGGCGCGCTGCCCTCGCGCGTGCTGCATCCG
GGCATGGCGCTCACGATCGAGCCGGGGCTGTACGTGCGCCCGGGCGAAGACGTGCCGCAGGCGTTCTGGAACATCGGCAT
CCGCATCGAGGACGACGCGTTCGTCACGCCGACGGGATGCGAGCTGATCACGCGCGGCGTGCCGGTGGCGGCCGACGAGA
TCGAGGCATTGATGCGCGACGCGCGGCCGGCGCCGCGCCCGCAGCCGTGA

Upstream 100 bases:

>100_bases
AATCGCAGCGCGCGCCGCATCGCACTGCCGCACCGCGCCGCGTCCGCATGAGCGGCGCGCCATCCGTCGCGCGCGCCCCG
CGCGACGGCGCTACAATCGC

Downstream 100 bases:

>100_bases
TCCGCGCGCCCCTTCTTTCCACCGAGACTCACGATTCACGAACGATGACGACCGCCGCCTCCACGCCCGCTTTCGACTTC
GACATCGCGATCGTCGGCGC

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MMNQPTEPAIALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEGARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTPF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERAAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP

Sequences:

>Translated_469_residues
MMNQPTEPAIALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEGARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTPF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERAAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
>Mature_469_residues
MMNQPTEPAIALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGD
APRSILFCRAKNPEREIWEGFHFGPEGARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRA
RARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTPF
DAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERAAPRDDDGALPSRVLHP
GMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=463, Percent_Identity=30.6695464362851, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI149589008, Length=493, Percent_Identity=29.4117647058824, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI260593665, Length=319, Percent_Identity=35.1097178683386, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI260593663, Length=331, Percent_Identity=31.4199395770393, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1789275, Length=446, Percent_Identity=42.6008968609865, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788728, Length=268, Percent_Identity=33.955223880597, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=30.1369863013699, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=493, Percent_Identity=29.6146044624746, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=379, Percent_Identity=28.2321899736148, Blast_Score=128, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=422, Percent_Identity=28.436018957346, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321118, Length=444, Percent_Identity=28.8288288288288, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI19920384, Length=482, Percent_Identity=33.6099585062241, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI21357079, Length=500, Percent_Identity=28.6, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51046; Mature: 51046

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNQPTEPAIALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
LTGFAEPDALLVLDASAAGDAPRSILFCRAKNPEREIWEGFHFGPEGARDAFGFDAAFPY
EEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
DALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRARARAGVAAPGAAFDLGPLLD
HHHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALY
CEEEECCCEEEEEECCCCEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHH
DIVLAAQEAAIAATRAGTPFDAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHH
FYMHRTGHWLGMDVHDCGDYRERAAPRDDDGALPSRVLHPGMALTIEPGLYVRPGEDVPQ
HHHHHCCCEEECCHHHCCCHHHHCCCCCCCCCCCHHHHCCCEEEEECCCEEECCCCHHHH
AFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
HHHHCCEEECCCCEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMNQPTEPAIALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
LTGFAEPDALLVLDASAAGDAPRSILFCRAKNPEREIWEGFHFGPEGARDAFGFDAAFPY
EEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
DALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRARARAGVAAPGAAFDLGPLLD
HHHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALY
CEEEECCCEEEEEECCCCEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHH
DIVLAAQEAAIAATRAGTPFDAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHH
FYMHRTGHWLGMDVHDCGDYRERAAPRDDDGALPSRVLHPGMALTIEPGLYVRPGEDVPQ
HHHHHCCCEEECCHHHCCCHHHHCCCCCCCCCCCHHHHCCCEEEEECCCEEECCCCHHHH
AFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP
HHHHCCEEECCCCEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]