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The map label for this gene is pntB [H]

Identifier: 237813749

GI number: 237813749

Start: 3412490

End: 3413950

Strand: Reverse

Name: pntB [H]

Synonym: GBP346_A3526

Alternate gene names: 237813749

Gene position: 3413950-3412490 (Counterclockwise)

Preceding gene: 237813750

Following gene: 237813748

Centisome position: 83.3

GC content: 65.5

Gene sequence:

>1461_bases
ATGAGCATGAACGTCGTCACGCTGCTGTATCTCGTTGCGTCGGTGTGCTTCATCCAGGCGCTGAAGGGGCTGTCGAACCC
GAAGAGCGCTAGACGAGGCAATCTATTCGGCATGGTCGGCATGGCGATCGCGATCCTCACGACCGTCGCGCTGATCGCGA
AGCAGGCCGCGTGGCTCGGCGCGAACCTGCCGCTCGGCCTCGCGCTCGTGTTCGGCGCGCTCGTGATCGGCGGCGCGGTG
GGGGCGGTGATCGCCGCGCGCGTCGAGATGACGAAGATGCCGGAGCTCGTCGCGGCGATGCACTCGCTGATCGGCCTCGC
GGCCGTGTGCATCGCGATCGCGGTGGTCGCGGAGCCGGAGGCGTTCGGGCTCGTGCCGCAGGATGCGAGCGCGCCGAACT
TCATTCCGTACGGCAACCGGATCGAGCTGTTCATCGGCACGTTCGTCGGCGCGATCACGTTCTCGGGCTCGGTGATCGCG
TTCGGCAAGCTGTCGGGCAAGTACAGGTTCCGGCTGTTCCAGGGCGCGCCCGTCGTCTATCCAGGCCAGCATCTGATCAA
CCTGATGCTCGCGCTCGCGATGCTCGGCTTCGGCATCCTGTTCTTCATCACGCAATCGTGGCTGCCGTTCGGGATCATGA
CGGCGATCGCGTTCGCGCTCGGCGTGCTGATCATCATTCCGATCGGCGGCGCGGACATGCCGGTCGTCGTGTCGATGCTG
AACTCGTACTCGGGATGGGCGGCGGCGGGCATCGGCTTTTCGCTGAACAACGCGATGCTGATCATCGCCGGCTCGCTCGT
CGGCTCGTCGGGCGCGATCCTGTCGTACATCATGTGCCACGCGATGAACCGCTCGTTCTTCAACGTGATCCTCGGCGGCT
TCGGCGGCGACGCGGCCGCGGCCGCGGCGACGGCGGGCGGCGCGAAGGAGCAGCGGCCGGTGAAGTCGGGCTCGGCGGAG
GATGCGTCGTTCATGCTCGGCAATGCGGAGACGGTCGTGATCGTGCCGGGCTACGGGCTGGCGGTGGCGCGCGCGCAGCA
CGCGCTCAAGGAGCTGACCGACAAGCTCGTCGAGAAGGGGATCGACGTGAAGTACGCGATCCACCCGGTCGCGGGGCGGA
TGCCGGGACACATGAACGTGCTGCTCGCGGAAGCCGAGGTGCCGTACGAGATCGTTCACGAGATGGAGGACATCAACGGC
GAGTTCGGGCAGGTGGACGTGGTGCTCGTGCTCGGGGCGAACGACGTGGTGAATCCGGCGGCGAAGAACGATCCGAAATC
GCCGATCGCGGGGATGCCGATCATCGAGGCGTACAAGGCGCGCACGGTGATCGTCAACAAGCGGTCGATGGCGGCGGGTT
ATGCGGGCCTCGACAACGAACTTTTCTACATGGACAAGACGATGATGGTCTTCGGCGATGCGAAGAAGGTCATCGAGGAT
ATGGTGAAGTCGGTCGAGTGA

Upstream 100 bases:

>100_bases
TCAACGTGTTCGGCGGCTTCCTCGTCACGCGGCGCATGCTCGAGATGTTCAAGAAGAAGGAGCCCAGGCAGAAAGCCGAC
CACGCGAAGGAGGGCGCGCG

Downstream 100 bases:

>100_bases
CGCGGCGGCACGCCCGGCCGGCGGCCGGGCGTTCGATGCATCGCGGGGCGGGTATCGCGGCGAGCGGGACGCGCGTGGCG
GGTCGTGCGTGGTGGGGGGC

Product: NAD(P) transhydrogenase, beta subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLGANLPLGLALVFGALVIGGAV
GAVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPEAFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIA
FGKLSGKYRFRLFQGAPVVYPGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSML
NSYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAAAAATAGGAKEQRPVKSGSAE
DASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKGIDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDING
EFGQVDVVLVLGANDVVNPAAKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIED
MVKSVE

Sequences:

>Translated_486_residues
MSMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLGANLPLGLALVFGALVIGGAV
GAVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPEAFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIA
FGKLSGKYRFRLFQGAPVVYPGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSML
NSYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAAAAATAGGAKEQRPVKSGSAE
DASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKGIDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDING
EFGQVDVVLVLGANDVVNPAAKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIED
MVKSVE
>Mature_485_residues
SMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLGANLPLGLALVFGALVIGGAVG
AVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPEAFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIAF
GKLSGKYRFRLFQGAPVVYPGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSMLN
SYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAAAAATAGGAKEQRPVKSGSAED
ASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKGIDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDINGE
FGQVDVVLVLGANDVVNPAAKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIEDM
VKSVE

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=495, Percent_Identity=45.8585858585859, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI122939153, Length=495, Percent_Identity=45.8585858585859, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1787886, Length=490, Percent_Identity=49.5918367346939, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17550456, Length=487, Percent_Identity=42.9158110882957, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 50817; Mature: 50686

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ANLPLGLALVFGALVIGGAVGAVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIAFGKLSGKYRFRLFQGAPVVY
HHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCEEE
PGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSML
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
NSYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAA
HCCCCCCHHCCCEECCCEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCHHH
AAATAGGAKEQRPVKSGSAEDASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKG
HHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
IDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDINGEFGQVDVVLVLGANDVVNPA
CCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
AKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIED
CCCCCCCCCCCCCHHHHHCCEEEEEECHHHHCCCCCCCCCEEEECCEEEEECCHHHHHHH
MVKSVE
HHHHCC
>Mature Secondary Structure 
SMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLG
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ANLPLGLALVFGALVIGGAVGAVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIAFGKLSGKYRFRLFQGAPVVY
HHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCEEEEEEEECCCEEE
PGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSML
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
NSYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAA
HCCCCCCHHCCCEECCCEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCHHH
AAATAGGAKEQRPVKSGSAEDASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKG
HHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
IDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDINGEFGQVDVVLVLGANDVVNPA
CCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
AKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIED
CCCCCCCCCCCCCHHHHHCCEEEEEECHHHHCCCCCCCCCEEEECCEEEEECCHHHHHHH
MVKSVE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]