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The map label for this gene is xdhA [H]

Identifier: 237813564

GI number: 237813564

Start: 3224945

End: 3226462

Strand: Reverse

Name: xdhA [H]

Synonym: GBP346_A3340

Alternate gene names: 237813564

Gene position: 3226462-3224945 (Counterclockwise)

Preceding gene: 237813567

Following gene: 237813563

Centisome position: 78.72

GC content: 71.81

Gene sequence:

>1518_bases
ATGAGTGAGCCGATCCGTTTCTATCATCGCCGGGCGATCCGCGAAGTCAGCGGCGCGAACGTCACCCGCACGGTGCTTCA
GTATCTGCGCGAGGACGCGCATTGCACCGGCACGAAGGAGGGCTGCGCGGAAGGCGACTGCGGCGCGTGCACGGTCGTCG
TCGGCGAACTGAACGACGCGGGCGGCGTCGAGTTCAAGGCGGTCAACGCGTGCATCCAGTTCCTGCCGACGCTCGATGGC
CGCGCGCTGTTCACCGTCGAGGACCTGCGCCAGCCGGACGGCGCGCTGCATCCGGCGCAGGAGGCGCTCGTCGAATGCCA
CGGCTCGCAATGCGGCTTCTGCACGCCGGGCTTCGCGATGTCGATGTGGGCGCTGTACGAGCGGCACGGGCACGAAGCGC
AGCGCGCCGATCGCACGACGCCGTCGCGCGCGCAGATCGCCGACGCGCTCACCGGCAATCTGTGCCGCTGCACCGGCTAC
CGTCCGATCGTCGACGCGGCGGTGCGCATGTTCGACGCGCGGCCGCCGAAGGCGCCCGTCGACGTCGCCGCGCTCGCGCG
CGCGCTGCAGGCGCTGCGCCGGGACGACACGTTCCATTACGAGCACGCGGGCCAGGCGTTCGACGCGCCGCGCACGCTCG
ACGCGCTCGCGCGGCTAAAGGCCGAGAAGCCCGCCGCGCGCGTGCTCGCGGGCAGCACCGACGTCGGCCTGTGGGTGACG
AAGCAACTGCGCGATCTGGGCGACGTGCTGTACGTCGGCCAGGTGCCCGAGCTGCGCCGGATCGTCGAGCACGACGACTG
GATCGAGATCGGCGCGGGCGCGTCGGTCGAGGCTGCGTATGCGGCGCTCGCCGCGCATTATCCGGAGCTCGTCGAGATGT
GGAAGCGCTTCGCCTCGCTGCCGATCCGCAACGCGGGGACGATCGGCGGCAACGTCGCGAACGGCTCGCCGATCGGCGAT
TCGATGCCGGGCCTGATCGCGCTCGGCGCGCGGGTGGTGCTGCGCGGCGGCCGCGCGGCGCGCGAGCTGCCGCTCGAGGA
TCTGTACGTCGGCTATCAGAAGAAGGACATGGCCGAGCACGAGCTCGTCATCGCGCTGAAGGTGCCCAGGCGCACCGGCG
CGCGCGCGAACCTGCGGTTTCGCACGTACAAGCTGTCGAAGCGCTTCGATTCCGACATCTCGGCCGTCTGCGCGGCGTTC
GCGTTCGAGGCCGACGGCGAGGTGCTCCGCGCGCCGCGCATCGCGTTCGGCGGGATGGCCGCGACGCCGAAGCGCGCAGC
GCATGCGGAAGCCGCGCTTGCCGGTGCCGTCTGGGACGAGGCCGCCGCGCTCGCCGCGATGCGCGCGCTCGACCACGATT
ACGCGCCGCTCACCGACATGCGCGCGACGAGCGCGTACCGGCTCGAGACCGCGAAGAACCTGCTGTACCGCTTCTGGCTG
GAGACCCGCCCGCACGATCCGCTGCCCGCGTCGGCCGTGAACGTGCGCGAAGTGGCCGCCGAGCCGGCCGCCTCCTGA

Upstream 100 bases:

>100_bases
AAACATACGACGACGGCCACGGCGGCCGGCCGCGCGCCGGTTCGGCGCCGCGCGGGCCTCCGCCGTCCGAGCATGTCCCC
ATTTTAGAGAACGACGCAAC

Downstream 100 bases:

>100_bases
CCGATCGACGCCAAGCGGAGCCATCGCAATGAATCAGCAAGCCGAACCTTTCCTGAGCGTCGCCGCCGATGCCGAGCGCG
ACGCGTTCCGGCAGGTCCAC

Product: xanthine dehydrogenase, small subunit

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSEPIRFYHRRAIREVSGANVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELNDAGGVEFKAVNACIQFLPTLDG
RALFTVEDLRQPDGALHPAQEALVECHGSQCGFCTPGFAMSMWALYERHGHEAQRADRTTPSRAQIADALTGNLCRCTGY
RPIVDAAVRMFDARPPKAPVDVAALARALQALRRDDTFHYEHAGQAFDAPRTLDALARLKAEKPAARVLAGSTDVGLWVT
KQLRDLGDVLYVGQVPELRRIVEHDDWIEIGAGASVEAAYAALAAHYPELVEMWKRFASLPIRNAGTIGGNVANGSPIGD
SMPGLIALGARVVLRGGRAARELPLEDLYVGYQKKDMAEHELVIALKVPRRTGARANLRFRTYKLSKRFDSDISAVCAAF
AFEADGEVLRAPRIAFGGMAATPKRAAHAEAALAGAVWDEAAALAAMRALDHDYAPLTDMRATSAYRLETAKNLLYRFWL
ETRPHDPLPASAVNVREVAAEPAAS

Sequences:

>Translated_505_residues
MSEPIRFYHRRAIREVSGANVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELNDAGGVEFKAVNACIQFLPTLDG
RALFTVEDLRQPDGALHPAQEALVECHGSQCGFCTPGFAMSMWALYERHGHEAQRADRTTPSRAQIADALTGNLCRCTGY
RPIVDAAVRMFDARPPKAPVDVAALARALQALRRDDTFHYEHAGQAFDAPRTLDALARLKAEKPAARVLAGSTDVGLWVT
KQLRDLGDVLYVGQVPELRRIVEHDDWIEIGAGASVEAAYAALAAHYPELVEMWKRFASLPIRNAGTIGGNVANGSPIGD
SMPGLIALGARVVLRGGRAARELPLEDLYVGYQKKDMAEHELVIALKVPRRTGARANLRFRTYKLSKRFDSDISAVCAAF
AFEADGEVLRAPRIAFGGMAATPKRAAHAEAALAGAVWDEAAALAAMRALDHDYAPLTDMRATSAYRLETAKNLLYRFWL
ETRPHDPLPASAVNVREVAAEPAAS
>Mature_504_residues
SEPIRFYHRRAIREVSGANVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELNDAGGVEFKAVNACIQFLPTLDGR
ALFTVEDLRQPDGALHPAQEALVECHGSQCGFCTPGFAMSMWALYERHGHEAQRADRTTPSRAQIADALTGNLCRCTGYR
PIVDAAVRMFDARPPKAPVDVAALARALQALRRDDTFHYEHAGQAFDAPRTLDALARLKAEKPAARVLAGSTDVGLWVTK
QLRDLGDVLYVGQVPELRRIVEHDDWIEIGAGASVEAAYAALAAHYPELVEMWKRFASLPIRNAGTIGGNVANGSPIGDS
MPGLIALGARVVLRGGRAARELPLEDLYVGYQKKDMAEHELVIALKVPRRTGARANLRFRTYKLSKRFDSDISAVCAAFA
FEADGEVLRAPRIAFGGMAATPKRAAHAEAALAGAVWDEAAALAAMRALDHDYAPLTDMRATSAYRLETAKNLLYRFWLE
TRPHDPLPASAVNVREVAAEPAAS

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=539, Percent_Identity=27.8293135435993, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI71773480, Length=99, Percent_Identity=47.4747474747475, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789231, Length=273, Percent_Identity=26.3736263736264, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786480, Length=151, Percent_Identity=36.4238410596026, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789232, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540638, Length=144, Percent_Identity=43.75, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17539860, Length=343, Percent_Identity=26.8221574344023, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32566215, Length=460, Percent_Identity=24.7826086956522, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17737937, Length=488, Percent_Identity=32.172131147541, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24647197, Length=495, Percent_Identity=27.4747474747475, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24647201, Length=518, Percent_Identity=26.6409266409266, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24647199, Length=499, Percent_Identity=28.0561122244489, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24647195, Length=491, Percent_Identity=27.0875763747454, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24647193, Length=498, Percent_Identity=26.1044176706827, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 54752; Mature: 54621

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPIRFYHRRAIREVSGANVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELNDA
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCC
GGVEFKAVNACIQFLPTLDGRALFTVEDLRQPDGALHPAQEALVECHGSQCGFCTPGFAM
CCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHH
SMWALYERHGHEAQRADRTTPSRAQIADALTGNLCRCTGYRPIVDAAVRMFDARPPKAPV
HHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCC
DVAALARALQALRRDDTFHYEHAGQAFDAPRTLDALARLKAEKPAARVLAGSTDVGLWVT
CHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHH
KQLRDLGDVLYVGQVPELRRIVEHDDWIEIGAGASVEAAYAALAAHYPELVEMWKRFASL
HHHHHHHCEEEECCCHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCC
PIRNAGTIGGNVANGSPIGDSMPGLIALGARVVLRGGRAARELPLEDLYVGYQKKDMAEH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCHHCCCCC
ELVIALKVPRRTGARANLRFRTYKLSKRFDSDISAVCAAFAFEADGEVLRAPRIAFGGMA
EEEEEEECCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCC
ATPKRAAHAEAALAGAVWDEAAALAAMRALDHDYAPLTDMRATSAYRLETAKNLLYRFWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHHHHHHHHH
ETRPHDPLPASAVNVREVAAEPAAS
HCCCCCCCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
SEPIRFYHRRAIREVSGANVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELNDA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCC
GGVEFKAVNACIQFLPTLDGRALFTVEDLRQPDGALHPAQEALVECHGSQCGFCTPGFAM
CCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHH
SMWALYERHGHEAQRADRTTPSRAQIADALTGNLCRCTGYRPIVDAAVRMFDARPPKAPV
HHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCC
DVAALARALQALRRDDTFHYEHAGQAFDAPRTLDALARLKAEKPAARVLAGSTDVGLWVT
CHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHH
KQLRDLGDVLYVGQVPELRRIVEHDDWIEIGAGASVEAAYAALAAHYPELVEMWKRFASL
HHHHHHHCEEEECCCHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCC
PIRNAGTIGGNVANGSPIGDSMPGLIALGARVVLRGGRAARELPLEDLYVGYQKKDMAEH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCHHCCCCC
ELVIALKVPRRTGARANLRFRTYKLSKRFDSDISAVCAAFAFEADGEVLRAPRIAFGGMA
EEEEEEECCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCC
ATPKRAAHAEAALAGAVWDEAAALAAMRALDHDYAPLTDMRATSAYRLETAKNLLYRFWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHHHHHHHHH
ETRPHDPLPASAVNVREVAAEPAAS
HCCCCCCCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]