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The map label for this gene is wbiH [H]

Identifier: 237813495

GI number: 237813495

Start: 3158205

End: 3159215

Strand: Reverse

Name: wbiH [H]

Synonym: GBP346_A3271

Alternate gene names: 237813495

Gene position: 3159215-3158205 (Counterclockwise)

Preceding gene: 237813496

Following gene: 237813494

Centisome position: 77.08

GC content: 59.94

Gene sequence:

>1011_bases
ATGTTCCAACTGAATTTGACCATCTTGTCCGCGATGGCGTTCGCATCGATCGCTGCGATCGTCACCGCGCTTATTCTCAA
ATGGCTTCTCGCGAGCGGATGGGCATGGCGGCTGGCGACTGATGTGCCGAACGCTCGCTCGATGCACACACGGCCGACGC
CGCGTATGGGCGGCTGGGGGATCGTGCCGGTTGGCGCGGTGGCCATTGGGATTGCCGCGCCACATCTATGGGGAATTGTC
GCGGCGATGCTGTTTCTGGCGATCGTCTCTCATATCGACGACCGTCGGGGGCTACCCGCGCGGGTTCGATTCGCTGCCCA
CCTCATCGCGTCCGCGGCGATTGCCGCGTTGTATTCGGGGGGCTTGGCATGGTTCTGGATCCCCATCGTCGCCGTCGGGC
TCGCGTGGCTGATCAACCTGTATAACTTCATGGACGGCGCAGATGGCCTTGCCGGGGGAATGACCGTCTTCGGTTTCGGC
AGCTATGCGTTTGCAGCACTCGCAGGACCTCATCCATCTGTCGGATTGGGTTGGGCGTGTGCGGCGATCGCGGGTGCGGC
GGCGGGATTCCTGCTCCTCAACTTCCATCCGGCCAAGCTTTTCCTGGGCGATGCGGGTTCGATTTCGCTCGGTTTGCTCG
CCGGGGCGTTCGGCTATTGGGGATGGCGTCATGCGGTCTGGCCGCTGTGGTTTCCGCTCGTTGTCTTTGCACCGTTTATT
GCCGATGCATCTGTAACATTGTTGCGACGTTTGTTACGAAGGGAAAAGTTCTGGGAAGCACATCGAGAGCATTATTATCA
GCGCATGGTGCGCTTGGGCGTCGGGCACGCGCGGACAGCGCTCTACTGGTACGCGACCATGCTGGTCGGCGCCGTCGTGT
CGCTTTCGGTATTGGCATGTTCTACCGCGGTCCAGTGGATGACTATCGCCGCTTGGGGTTCGATCCTGTTTCTCTTGGGC
GTAGCCATCGATGTGTGCTGGAGTCGCTTCCAAATACTTACATCAAAATAA

Upstream 100 bases:

>100_bases
TGCTCGACTGGCGTCCGCCGCGCTCGAGCGAAGAGGGGCTCGCCGAAACGGCGTGCTGGTTCAAGTCGCTGGGCCGACGC
TAGTCGCCGGAAGAGGCACG

Downstream 100 bases:

>100_bases
CGCAACATGACGCGAGCATTTTGCCCGAAGGCTTCGTGGCTTTCCCTGGGCGCCTTTCTGTTCGATCTGATGGCGGTCGT
ATGCGCGTGGTTGATCGCGT

Product: glycosyl transferase family protein

Products: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine; UMP [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MFQLNLTILSAMAFASIAAIVTALILKWLLASGWAWRLATDVPNARSMHTRPTPRMGGWGIVPVGAVAIGIAAPHLWGIV
AAMLFLAIVSHIDDRRGLPARVRFAAHLIASAAIAALYSGGLAWFWIPIVAVGLAWLINLYNFMDGADGLAGGMTVFGFG
SYAFAALAGPHPSVGLGWACAAIAGAAAGFLLLNFHPAKLFLGDAGSISLGLLAGAFGYWGWRHAVWPLWFPLVVFAPFI
ADASVTLLRRLLRREKFWEAHREHYYQRMVRLGVGHARTALYWYATMLVGAVVSLSVLACSTAVQWMTIAAWGSILFLLG
VAIDVCWSRFQILTSK

Sequences:

>Translated_336_residues
MFQLNLTILSAMAFASIAAIVTALILKWLLASGWAWRLATDVPNARSMHTRPTPRMGGWGIVPVGAVAIGIAAPHLWGIV
AAMLFLAIVSHIDDRRGLPARVRFAAHLIASAAIAALYSGGLAWFWIPIVAVGLAWLINLYNFMDGADGLAGGMTVFGFG
SYAFAALAGPHPSVGLGWACAAIAGAAAGFLLLNFHPAKLFLGDAGSISLGLLAGAFGYWGWRHAVWPLWFPLVVFAPFI
ADASVTLLRRLLRREKFWEAHREHYYQRMVRLGVGHARTALYWYATMLVGAVVSLSVLACSTAVQWMTIAAWGSILFLLG
VAIDVCWSRFQILTSK
>Mature_336_residues
MFQLNLTILSAMAFASIAAIVTALILKWLLASGWAWRLATDVPNARSMHTRPTPRMGGWGIVPVGAVAIGIAAPHLWGIV
AAMLFLAIVSHIDDRRGLPARVRFAAHLIASAAIAALYSGGLAWFWIPIVAVGLAWLINLYNFMDGADGLAGGMTVFGFG
SYAFAALAGPHPSVGLGWACAAIAGAAAGFLLLNFHPAKLFLGDAGSISLGLLAGAFGYWGWRHAVWPLWFPLVVFAPFI
ADASVTLLRRLLRREKFWEAHREHYYQRMVRLGVGHARTALYWYATMLVGAVVSLSVLACSTAVQWMTIAAWGSILFLLG
VAIDVCWSRFQILTSK

Specific function: Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to t

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.13 [C]

Molecular weight: Translated: 36246; Mature: 36246

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQLNLTILSAMAFASIAAIVTALILKWLLASGWAWRLATDVPNARSMHTRPTPRMGGWG
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCC
IVPVGAVAIGIAAPHLWGIVAAMLFLAIVSHIDDRRGLPARVRFAAHLIASAAIAALYSG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
GLAWFWIPIVAVGLAWLINLYNFMDGADGLAGGMTVFGFGSYAFAALAGPHPSVGLGWAC
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECHHHHHHHHCCCCCCCCHHHHH
AAIAGAAAGFLLLNFHPAKLFLGDAGSISLGLLAGAFGYWGWRHAVWPLWFPLVVFAPFI
HHHHHHHHHHHHEEECHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADASVTLLRRLLRREKFWEAHREHYYQRMVRLGVGHARTALYWYATMLVGAVVSLSVLAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
STAVQWMTIAAWGSILFLLGVAIDVCWSRFQILTSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFQLNLTILSAMAFASIAAIVTALILKWLLASGWAWRLATDVPNARSMHTRPTPRMGGWG
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCC
IVPVGAVAIGIAAPHLWGIVAAMLFLAIVSHIDDRRGLPARVRFAAHLIASAAIAALYSG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
GLAWFWIPIVAVGLAWLINLYNFMDGADGLAGGMTVFGFGSYAFAALAGPHPSVGLGWAC
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECHHHHHHHHCCCCCCCCHHHHH
AAIAGAAAGFLLLNFHPAKLFLGDAGSISLGLLAGAFGYWGWRHAVWPLWFPLVVFAPFI
HHHHHHHHHHHHEEECHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADASVTLLRRLLRREKFWEAHREHYYQRMVRLGVGHARTALYWYATMLVGAVVSLSVLAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
STAVQWMTIAAWGSILFLLGVAIDVCWSRFQILTSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Undecaprenyl phosphate; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine [C]

Specific reaction: Undecaprenyl phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine --> Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP [C]

General reaction: Substituted phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12101296; 9384377 [H]