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The map label for this gene is bcr [H]

Identifier: 237813423

GI number: 237813423

Start: 3094212

End: 3095447

Strand: Reverse

Name: bcr [H]

Synonym: GBP346_A3198

Alternate gene names: 237813423

Gene position: 3095447-3094212 (Counterclockwise)

Preceding gene: 237813429

Following gene: 237813414

Centisome position: 75.52

GC content: 71.36

Gene sequence:

>1236_bases
ATGCCTCACGTCGCACGACGCCGGCCCGACGGCCGGCTGATCCTGTTGCTCGGCGCGCTCGCCGCGTGCGGGCCGATCGC
CACCGACATGTATCTGCCGAGCCTGCCCGCGATCGCCGGCGGCTTCGGCGTGACCGCGGCCGCCGCGCAGCGCACGCTCA
CGAGTTTCATGGCCGGCTTCTCGATCGGCATGCTGCTCTACGGCCCGCTATCCGATACCTACGGCCGCCGTCCCGTGCTG
CTCGGCGGCATCGCGCTCTTCACGCTCGCGAGCGTGGGCTGTTTCGTCGCCGGCTCGATCGACATGCTGATCGCCGTGCG
CTTCCTGCAGGCGTTCGGCGCGGGCGCCGCTTCGGTACTCGCGCGCGCGATCGCGCGCGACGCGCACGAGCCGGCCGACG
CGGCGAAGGTGCTGTCGATGGTCGCGATCGTCACCGCGATCGGGCCGCTCCTCGCGCCGCTCATCGGCGGGCAGGTGCTG
CGCTTCTCCGGCTGGCGCGGCGTGTTCGTCGTGCTCGCGCTGTTCGGCGCGGTCTGCGCGACGGCCGCGTACCTGCGCGT
GCCCGAGACTTGGCCGCGCGAGAAGCGCGCGAGCTCGGCCGTGCTCAACTCGTTCGCCGCGTATGGGCGCATCCTCGTCG
ATCCCGTCGCGTGGGGCCATATGCTGTGCGGCGGAATGGCGTTCGCGTCGATGTTCGCGTACATCACCGCGACGCCGTTC
GTCTACATCGACTACTTCCATGTGTCGCCGCAGCACTACGGGCTGCTGTTCGGGCTGAACGTCATCGGCATCATGCTCGG
CAACTTCCTGAACGCGCGCCTCGTCGGCCGGGTCGGCTCGCTGAAGATCATCGCGGGCGCATCGTTGCTGAGTGGCGCGG
CGTCGTTCGCGGTCGCGTTCTTCGCGCTGACGGGGCTGGGCGGATTGTGGTCGATCGTCGCGAGCCTCTTTTTCGTGGTC
GGCGTGGTCGGCATCCTGTCCGCGAACTGCACGACCGACCTGATGCTGCGCTATCCGCACAACGCGGGCGCCGCGGCCGC
CGTGTTCGGCGCGATGCAGCTCGCGCTCGGCGCGCTCGCGAGCGCCGCGATCGGCGCGCTCGCGAACGGCACGCCGTTCG
CGATGGGCGTGACGATCGGCGCGACCGGCCTGCTGTGCCTCGGCGGGCGCATGCTCGTGCTGCGCTGGCACGGCCGGCCG
GTGAAGGGCGCGCTGGGCCGCGTCGACGCCGCCTGA

Upstream 100 bases:

>100_bases
CGTACAATCGACACCTCGCGGCGGGCCGACCGGCCGCCGTCTCCTTGCATGGCCGTCTCGTCCGCCACCCGCGCGAGGCC
GCCGCTTCCGTGGAATTCCA

Downstream 100 bases:

>100_bases
GCGCCACGGGCGGCGCGGCGCCCACGCATGGCCCGCGCCGTGCCCGCGCGCCGCGTCGAGCGTGCGCTCCGCATGCGTTC
CGGCTCGGCGTGCGCGGGAC

Product: drug resistance transporter, Bcr/CflA family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVL
LGGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVLARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVL
RFSGWRGVFVVLALFGAVCATAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPF
VYIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAFFALTGLGGLWSIVASLFFVV
GVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRP
VKGALGRVDAA

Sequences:

>Translated_411_residues
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVL
LGGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVLARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVL
RFSGWRGVFVVLALFGAVCATAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPF
VYIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAFFALTGLGGLWSIVASLFFVV
GVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRP
VKGALGRVDAA
>Mature_410_residues
PHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVLL
GGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVLARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVLR
FSGWRGVFVVLALFGAVCATAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPFV
YIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAFFALTGLGGLWSIVASLFFVVG
VVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRPV
KGALGRVDAA

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=398, Percent_Identity=33.4170854271357, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI48994889, Length=394, Percent_Identity=29.4416243654822, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790146, Length=202, Percent_Identity=34.1584158415842, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787065, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082312, Length=342, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790794, Length=223, Percent_Identity=23.7668161434978, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790195, Length=138, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=168, Percent_Identity=26.1904761904762, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322071, Length=165, Percent_Identity=28.4848484848485, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42262; Mature: 42130

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS ; PS00456 NA_SOLUT_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGF
CCCCCCCCCCCCEEEHHHHHHHCCHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
SIGMLLYGPLSDTYGRRPVLLGGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVL
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHH
ARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLALFGAVCA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
TAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPF
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCE
VYIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
FALTGLGGLWSIVASLFFVVGVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALA
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
SAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRPVKGALGRVDAA
HHHHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
PHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGF
CCCCCCCCCCCEEEHHHHHHHCCHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
SIGMLLYGPLSDTYGRRPVLLGGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVL
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHH
ARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLALFGAVCA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
TAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPF
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCE
VYIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
FALTGLGGLWSIVASLFFVVGVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALA
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
SAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRPVKGALGRVDAA
HHHHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]