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The map label for this gene is glk [H]

Identifier: 237813417

GI number: 237813417

Start: 3087834

End: 3089759

Strand: Direct

Name: glk [H]

Synonym: GBP346_A3192

Alternate gene names: 237813417

Gene position: 3087834-3089759 (Clockwise)

Preceding gene: 237813416

Following gene: 237813418

Centisome position: 75.34

GC content: 68.74

Gene sequence:

>1926_bases
ATGTCTACTGGTGCGCAAACTAAGGCCGCCGCGGCGAGCCAGCACGCGGACGGGCCGCGCCTATTGGCCGACGTCGGCGG
CACGAACGCGCGCTTCGCGCTCGAGACGGGCCCGGGAGAAATCACGCAGATCCGCGTGTACCCGGGCGCCGAGTATCCGA
CGCTCACCGACGCGATCCGCAAGTACCTGAAGGACGCGAAAATCGGCCGCGTGAATCACGCGGCGATCGCGATCGCGAAC
CCCGTCGACGGCGATCAGGTCCGGATGACGAATCACAACTGGAGCTTCTCGATCGAGGCGACGCGCCGCGCGCTCGGCTT
CGATACGCTGCTCGTCGTCAACGATTTCACCGCGCTCGCGATGGCGCTGCCCGGCCTGACCGATGCGCAGCGCGTACAGA
TCGGCGGCGGCACGCGCCGGCAGAACAGCGTGATCGGCCTGATGGGGCCGGGCACGGGGCTCGGCGTGTCGGGGCTCATT
CCCGCCGACGACCGCTGGATCGCGCTCGGCAGCGAAGGCGGCCACGCGACGTTCGCGCCGATGGACGAGCGCGAGGATCT
CGTGCTGCAATACGCGCGCCGCAAGTATCCTCACGTGTCGTTCGAGCGCGTGTGCGCGGGCCCGGGCATGGAGATCATCT
ATCGCGCGCTCGCCGCGCGCGACAAGAAGCGCATCGCCGCGAACGTCGACACGGCCGACATCGTCGAGCGCGCGCACGCG
GGCGATGCGCTCGCGCTCGAGGCGGTCGAGTGCTTCTGCGCGATTCTCGGCACGTTCGCCGGCAACCTCGCGGTCACGCT
CGGCGCGTTGGGCGGCATCTATATCGGCGGCGGCGTCGTGCCGAAGCTCGGCGAGCTGTTCATGCGCTCGCCGTTTCGCG
CGCGCTTCGAGGCGAAGGGCCGCTTCGAGGCGTATCTCGCGAACATCCCGACCTACCTGATCACCGCGGAATACCCGGCG
TTTCTCGGCGTATCGGCGATCCTCGCCGAGCAACTGTCGAACCGCACGGGCGGCGCGTCGTCGGCCGTGTTCGAGCGCAT
CCGCCAGATGCGCGACGCGTTGACGCCCGCCGAGCGGCGCGTCGCCGATCTCGCGCTCAACCATCCGCGCTCGATCATCA
ACGATCCGATCGTCGACATCGCGCGCAAGGCCGACGTGAGCCAGCCCACCGTGATCCGCTTCTGCCGCTCGCTCGGCTGC
CAGGGGCTGTCGGACTTCAAGCTGAAGCTCGCGACGGGCCTCACCGGCACGATCCCGATGAGCCACAGCCAGGTGCATCT
GGGCGACACCGCGACCGATTTCGGCGCGAAGGTGCTCGACAACACGGTATCGGCGATCCTTCAGTTGCGCGAGCATCTGA
ACTTCGAGCACGTCGAGCAGGCGATCGACATCCTGAACAATGCGCGGCGCATCGAGTTCTACGGCCTGGGCAATTCGAAC
ATCGTCGCGCAGGACGCGCACTACAAGTTCTTCCGCTTCGGGATTCCGACGATCGCGTACGGCGACCTGTACATGCAGGC
GGCGTCGGCCGCGCTCCTCGGCAAGGGCGACGTGATCGTCGCGGTGTCGAAGTCGGGGCGCGCGCCGGAGCTGTTGCGCG
TGCTCGACGTCGCGATGCAGGCGGGCGCGAAGGTGATCGCGATCACGTCGAGCAACACGCCGCTCGCCAAGCGCGCGACG
GTCGCGCTCGAGACCGATCACATCGAGATGCGCGAGTCGCAGTTGTCGATGATCTCGCGGATCCTGCATCTCGTGATGAT
CGACATCCTCGCGGTCGGCGTCGCGATCCGCCGCGCCGCGCCGAACGCGGAGCTCGCGGAGGCGATGGCGCGCGCGAAGG
CGCGCGCGGGCGCGAGCGCGGGCGACGAGGCCGCCGACGTGCTCGACTGGCTGAGCCACGGCGCGGCGCCCGCGGCGAAG
GACTGA

Upstream 100 bases:

>100_bases
ATCGCGGGAAGCCGCAAGCGCGCGGTGCTCGAGGCGGCCGCGGCCGCGCCGCAGAAGAACGCGATTTCGCAACTGGCCAA
CGACAAGGGGACGAAGCTCG

Downstream 100 bases:

>100_bases
CGCACGCGGCGCACGCGCACCGGCGCGCGACGCAATGCGACGCGACGCGCAGCCATGATGCCGGAGCCTTCGCGCTCCGG
CATCTTTCTTCGGATCATCG

Product: bifunctional glucokinase/RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSTGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRKYLKDAKIGRVNHAAIAIAN
PVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLI
PADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHA
GDALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPA
FLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAAPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAK
D

Sequences:

>Translated_641_residues
MSTGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRKYLKDAKIGRVNHAAIAIAN
PVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLI
PADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHA
GDALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPA
FLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAAPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAK
D
>Mature_640_residues
STGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIRKYLKDAKIGRVNHAAIAIANP
VDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLIP
ADDRWIALGSEGGHATFAPMDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHAG
DALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKGRFEAYLANIPTYLITAEYPAF
LGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQ
GLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNI
VAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATV
ALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAAPNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKD

Specific function: Not Highly Important In E.Coli As Glucose Is Transported Into The Cell By The Pts System Already As Glucose 6-Phosphate. [C]

COG id: COG0837

COG function: function code G; Glucokinase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788732, Length=316, Percent_Identity=46.2025316455696, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1788159, Length=258, Percent_Identity=37.2093023255814, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082369, Length=251, Percent_Identity=28.2868525896414, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788767, Length=249, Percent_Identity=26.5060240963855, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI87082130, Length=226, Percent_Identity=28.7610619469027, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 68378; Mature: 68247

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIR
CCCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDAKIGRVNHAAIAIANPVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALA
HHHHCCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLIPADDRWIALGSEGGHATFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEECC
MDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHA
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHCC
GDALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHCCCC
RFEAYLANIPTYLITAEYPAFLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERR
CHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAA
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKD
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STGAQTKAAAASQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGAEYPTLTDAIR
CCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDAKIGRVNHAAIAIANPVDGDQVRMTNHNWSFSIEATRRALGFDTLLVVNDFTALA
HHHHCCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGGGTRRQNSVIGLMGPGTGLGVSGLIPADDRWIALGSEGGHATFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEECC
MDEREDLVLQYARRKYPHVSFERVCAGPGMEIIYRALAARDKKRIAANVDTADIVERAHA
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHCC
GDALALEAVECFCAILGTFAGNLAVTLGALGGIYIGGGVVPKLGELFMRSPFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHCCCC
RFEAYLANIPTYLITAEYPAFLGVSAILAEQLSNRTGGASSAVFERIRQMRDALTPAERR
CHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAVGVAIRRAA
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNAELAEAMARAKARAGASAGDEAADVLDWLSHGAAPAAKD
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA