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The map label for this gene is gmk [H]

Identifier: 237813380

GI number: 237813380

Start: 3054599

End: 3055282

Strand: Reverse

Name: gmk [H]

Synonym: GBP346_A3153

Alternate gene names: 237813380

Gene position: 3055282-3054599 (Counterclockwise)

Preceding gene: 237813381

Following gene: 237813379

Centisome position: 74.54

GC content: 65.64

Gene sequence:

>684_bases
ATGACCGATTCGAACCGCGACGGCGCAGCCGCGCATTCGCTGCACGCCGGCGTCTATCCCGGCAATCTCTTCATGGTCGT
CGCGCCGTCGGGCGCGGGCAAGTCGACGCTCGTCAACGCGCTGCTGTCGAAGGACCCGGAGATTCGCCTGTCGATTTCGT
ACACGACGCGCAAGCCGCGCCCCGGCGAACAGGACGGCCAGCACTATCACTTCACGACCGTCGAGGATTTCCGCGAGCGC
CATGCGCGCCACGAGTTTCTCGAAAGCGCCGAGGTGCACGGCAATTACTACGGCACGTCGCGCGTGTGGATCGAAGAGCA
GATGAAGATCGGCCACGACGTGCTGCTCGAAATCGATTGGCAGGGCGCGCAGCAGGTGAAGAAGCAGTTCCGCAACGCGG
TCGGCATCTTCATCCTGCCGCCGTCGCTCGCGGCGCTCGAGGAGCGGCTCAAAAAGCGCGGGCAGGACGAGCCGAACGTG
ATCACGCGGCGCCTGCTCGCCGCGGGCAGCGAGATCGCGCACGCGGCGGAAGCGCAGTACGTCGTCATCAACGAGACCTT
CGAGCACGCGCTCGCCGAGCTCGAGTGCATCGTCGCGGCGACGCGCCTGCGCTTCACGTCGCAATATGCGCGGCATGCCG
AACTATTCGTCGAGCTCGGCATTCATCTGCCGCACGCGGAGTGA

Upstream 100 bases:

>100_bases
CTCGAAGGCGGCGGCGAAGGAGCTCGCCGACGCGTCGATGGCGCTCAAGCTGCTGATCGAGCAGATGCGCGAGCAAGTGC
AAAACCTGGAGTAACGCAAC

Downstream 100 bases:

>100_bases
CGGCGGGCAACGAGACACATAAGGTAGAATAAGCAACATATTCAGAAGGAACGACCCAACATGGCTCGCATTACCGTTGA
AGACTGCCTGAAGCAGATTC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRER
HARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNV
ITRRLLAAGSEIAHAAEAQYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE

Sequences:

>Translated_227_residues
MTDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRER
HARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNV
ITRRLLAAGSEIAHAAEAQYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
>Mature_226_residues
TDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRERH
ARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVI
TRRLLAAGSEIAHAAEAQYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.7142857142857, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.7142857142857, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=37.7142857142857, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4505237, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118259, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118255, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118263, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=49.7512437810945, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.3626373626374, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356141, Length=153, Percent_Identity=40.5228758169935, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25459; Mature: 25328

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPR
CCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
PGEQDGQHYHFTTVEDFRERHARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDW
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHHCCCEEEEEECC
QGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHAAEAQY
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCE
VVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPR
CCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
PGEQDGQHYHFTTVEDFRERHARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDW
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHHCCCEEEEEECC
QGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHAAEAQY
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCE
VVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA