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The map label for this gene is cysM [H]

Identifier: 237813287

GI number: 237813287

Start: 2968429

End: 2969340

Strand: Reverse

Name: cysM [H]

Synonym: GBP346_A3054

Alternate gene names: 237813287

Gene position: 2969340-2968429 (Counterclockwise)

Preceding gene: 237813288

Following gene: 237813285

Centisome position: 72.45

GC content: 64.47

Gene sequence:

>912_bases
GTGACGTTCATGGCTTACAAAACTATCGAAGACACGATCGGCAATACGCCGCTCGTGCAACTCGTCCGCTTGCCGGACGA
CGAGATTCGCGCCCGCAACAACGTGATTCTCGCGAAGCTGGAAGGCAACAATCCGGCGGGCTCGGTGAAGGACCGTCCCG
CGCTGTCGATGATCCGCAAGGCGGAAGAGCGCGGCACGATCAAGCCGGGCGACACGCTGATCGAGGCGACGAGCGGCAAT
ACCGGCATCGCGCTCGCGATGGCGGCGGCGATCCGCGGCTACAAGATGGTGCTGATCATGCCGGAGGATCTGTCCATCGA
GCGTCGCCAGAGCATGGCCGCGTATGGCGCGGAAATCGTGCTGACGCCGGTGAAGGGCGGCATGGAATTCGCGCGCGATC
TCGCCGACCAGATGCAGCGCGAAGGCAAGGGCGTGATCCTCGATCAGTTCGCGAATCCGGACAATCCGCTCGCGCATTAC
GAGGGCACGGGCCCTGAAATCTGGCGCGAGACCGAGGGCCGCGTCACGCACTTCGTGTCCGCGATGGGCACGACGGGCAC
GATCATGGGCACGTCGCAGTATCTGAAGGAAAGGAATCCGACCGTCGAGATCGTCGGCGCGCAGCCCGAGGAGGGTTCGC
GGATTCCCGGCATCCGCAAGTGGCCGGAAGCGTATTTGCCGAAGATTTTCGATCGCAGCCGCATCGACCGCGTCGAGAAC
GTGAGCCAGGCCGCGTCCGAAGCGATGGCGCGCAAGCTCGCGGCTGTCGAAGGCATTTTCTGCGGCATCTCGTCGGGCGG
CGCATGCGAAGTCGCGTTGCGCGTCGCGCGGCAGGTGGAGAATGCGACGATCGTGTTCGTCGTCTGCGACCGCGGCGACC
GCTATCTGTCGACGGGCGTGTTCCCCGCGTAA

Upstream 100 bases:

>100_bases
TTCGGAACGCCGGGGCGCTCGGCGGCGGGCTTGACGGGGGGCGTGCGCGCGCGATTCTCCGCTGGTTTACAATCGATCCA
TTCATCGGCATCGGATAAAC

Downstream 100 bases:

>100_bases
CGCGCGGCGGCGTCTCGCGCGCATGTGAAACCGCGCCTGATAAGCTGTTCGCGCAGCAGGGCAGGTTCGACTGCTCGCTT
GCGGCGAGCCCGCAATCCTG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTFMAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMIRKAEERGTIKPGDTLIEATSGN
TGIALAMAAAIRGYKMVLIMPEDLSIERRQSMAAYGAEIVLTPVKGGMEFARDLADQMQREGKGVILDQFANPDNPLAHY
EGTGPEIWRETEGRVTHFVSAMGTTGTIMGTSQYLKERNPTVEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRIDRVEN
VSQAASEAMARKLAAVEGIFCGISSGGACEVALRVARQVENATIVFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_303_residues
MTFMAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMIRKAEERGTIKPGDTLIEATSGN
TGIALAMAAAIRGYKMVLIMPEDLSIERRQSMAAYGAEIVLTPVKGGMEFARDLADQMQREGKGVILDQFANPDNPLAHY
EGTGPEIWRETEGRVTHFVSAMGTTGTIMGTSQYLKERNPTVEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRIDRVEN
VSQAASEAMARKLAAVEGIFCGISSGGACEVALRVARQVENATIVFVVCDRGDRYLSTGVFPA
>Mature_302_residues
TFMAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMIRKAEERGTIKPGDTLIEATSGNT
GIALAMAAAIRGYKMVLIMPEDLSIERRQSMAAYGAEIVLTPVKGGMEFARDLADQMQREGKGVILDQFANPDNPLAHYE
GTGPEIWRETEGRVTHFVSAMGTTGTIMGTSQYLKERNPTVEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRIDRVENV
SQAASEAMARKLAAVEGIFCGISSGGACEVALRVARQVENATIVFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=302, Percent_Identity=37.7483443708609, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI295821200, Length=302, Percent_Identity=37.7483443708609, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4557415, Length=302, Percent_Identity=37.7483443708609, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=62.3728813559322, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=42.5867507886435, Blast_Score=197, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=43.6065573770492, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=42.7152317880795, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.4343434343434, Blast_Score=213, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=41.6666666666667, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=40.7284768211921, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=36.7924528301887, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=37.6175548589342, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=36.7924528301887, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=38.6075949367089, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=32.4324324324324, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=39.2282958199357, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=39.2282958199357, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32973; Mature: 32842

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFMAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMIRK
CCEEEEEHHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
AEERGTIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSIERRQSMAAYGAEIV
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEE
LTPVKGGMEFARDLADQMQREGKGVILDQFANPDNPLAHYEGTGPEIWRETEGRVTHFVS
EEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
AMGTTGTIMGTSQYLKERNPTVEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRIDRVEN
HCCCCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VSQAASEAMARKLAAVEGIFCGISSGGACEVALRVARQVENATIVFVVCDRGDRYLSTGV
HHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCC
FPA
CCC
>Mature Secondary Structure 
TFMAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMIRK
CEEEEEHHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
AEERGTIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSIERRQSMAAYGAEIV
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEE
LTPVKGGMEFARDLADQMQREGKGVILDQFANPDNPLAHYEGTGPEIWRETEGRVTHFVS
EEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
AMGTTGTIMGTSQYLKERNPTVEIVGAQPEEGSRIPGIRKWPEAYLPKIFDRSRIDRVEN
HCCCCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VSQAASEAMARKLAAVEGIFCGISSGGACEVALRVARQVENATIVFVVCDRGDRYLSTGV
HHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCC
FPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]