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The map label for this gene is fabF [H]

Identifier: 237813204

GI number: 237813204

Start: 2892240

End: 2893478

Strand: Reverse

Name: fabF [H]

Synonym: GBP346_A2969

Alternate gene names: 237813204

Gene position: 2893478-2892240 (Counterclockwise)

Preceding gene: 237813205

Following gene: 237813203

Centisome position: 70.6

GC content: 65.94

Gene sequence:

>1239_bases
GTGAGCCGCCGTCGTGTTGTTGTTACAGGCCTTGGGCTGATTTCGCCTGTTGGCAATAATGTTGCCGACGGCTGGGCCAA
TCTCGTGGCCGGCAAGTCCGGCATCGTCAATATCACGAAGTTCGACGCGACGAACTTCTCGACCCGCTTCGCGGGCGAGG
TGAAGGGCTTCAACGTCGAGGAGTACATCCCGGCGAAGGAAGCGCGCCACATGGATACGTTCATCCATTACGGCATCGCG
GCCGGCATGCAGGCGATGCAGGACAGCGGCTTCCAGGTCACCGACGAAAACGCGGAGCGCGTCGGCGTCGTGGTCGGCTC
GGGCATCGGCGGGCTGCCGATGATCGAAGTCACGCAGACCGAGCTGCTCAACCGCGGCCCGCGCCGGATCTCGCCGTTCT
TCGTGCCGGCGTCGATCATCAACATGATCTCCGGCCACCTGTCGATCAAGTTCGGCATCAAGGGCCCGAATCTCGCGATC
GTCACCGCGTGCACGACCGGCCTGCACTGCATCGGCGAGGCCGCGCGTCTGATCGAATACGGCGACGCCGACGTGATGAT
CGCGGGCGGCGCGGAAGCGACCGTGTCGCCGCTCGGCATCGGCGGCTTCGCGGCGGCGCGCGCGCTGTCGCAGCGCAACG
ACGATCCGGCGACGGCGAGCCGTCCGTGGGACAAGGATCGCGACGGCTTTGTGCTCGGCGAGGGCGCGGGCGTGATGGTG
CTCGAGGAGTACGAGCACGCGAAGGCGCGCGGCGCGAAGATCTACGCGGAAGTCGCGGGCTACGGGATGAGCGGCGACGC
GTACCACATGACGGCGCCGCTCGAGAACGGCGACGGCGCACGTCGCTGCATGCTGGCCGCGCTGCGCAACGCGGGCGTGA
ACGCCGATCAGGTGAATTACCTGAACGCGCACGGCACGTCGACGCCGCTCGGCGATCTGGCCGAGACCGTCGCGATCAAG
CGCGCGTTCGGCGATCACTCGAAGGACATCGTCGTCAACTCGACCAAGTCGATGACGGGGCACTTGCTCGGCGGCGCCGG
CGGGCTCGAATCGGTGTTCACGGTCCTTGCCGTCCACAACCAGGTGTCGCCGCCGACGATCAACATCTTCAACCAGGACC
CCGAGTGCGATCTCGACTATTGCGCGAACGAAGCGCGCGAGATGAAGATCGACGTCGCGTTGAAGAACTCCTTCGGCTTC
GGCGGGACTAACGGCACGCTGGTCTTCAAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GCGTTCTCGCCGGCCGAGCTAACAGCCACAGGGTTCGCAGGGGTGGTTCCTGTGGCCGCTGTGGCTTTTGTTTTAGTCAT
TCAATGGAAAAGAGGTTACC

Downstream 100 bases:

>100_bases
CGCGGGGTCGCTTGACGGAGCCGTTCCATGCCGCATCGGCAGGCACGCAGCACGTCGTGCTGCGCGCGTCGGCGTGCCTG
CGCGTCGCGTGCGCGCTGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIVNITKFDATNFSTRFAGEVKGFNVEEYIPAKEARHMDTFIHYGIA
AGMQAMQDSGFQVTDENAERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGIKGPNLAI
VTACTTGLHCIGEAARLIEYGDADVMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMV
LEEYEHAKARGAKIYAEVAGYGMSGDAYHMTAPLENGDGARRCMLAALRNAGVNADQVNYLNAHGTSTPLGDLAETVAIK
RAFGDHSKDIVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEAREMKIDVALKNSFGF
GGTNGTLVFKRA

Sequences:

>Translated_412_residues
MSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIVNITKFDATNFSTRFAGEVKGFNVEEYIPAKEARHMDTFIHYGIA
AGMQAMQDSGFQVTDENAERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGIKGPNLAI
VTACTTGLHCIGEAARLIEYGDADVMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMV
LEEYEHAKARGAKIYAEVAGYGMSGDAYHMTAPLENGDGARRCMLAALRNAGVNADQVNYLNAHGTSTPLGDLAETVAIK
RAFGDHSKDIVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEAREMKIDVALKNSFGF
GGTNGTLVFKRA
>Mature_411_residues
SRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIVNITKFDATNFSTRFAGEVKGFNVEEYIPAKEARHMDTFIHYGIAA
GMQAMQDSGFQVTDENAERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGIKGPNLAIV
TACTTGLHCIGEAARLIEYGDADVMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVL
EEYEHAKARGAKIYAEVAGYGMSGDAYHMTAPLENGDGARRCMLAALRNAGVNADQVNYLNAHGTSTPLGDLAETVAIKR
AFGDHSKDIVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEAREMKIDVALKNSFGFG
GTNGTLVFKRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=47.8468899521531, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=54.0540540540541, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=24.0184757505774, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=62.378640776699, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=39.9515738498789, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=36.8038740920097, Blast_Score=251, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=41.5686274509804, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=417, Percent_Identity=23.9808153477218, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=23.5436893203883, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=35.5704697986577, Blast_Score=273, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=44.9760765550239, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221330659, Length=382, Percent_Identity=25.130890052356, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920632, Length=382, Percent_Identity=25.130890052356, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=427, Percent_Identity=22.7166276346604, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43437; Mature: 43306

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIVNITKFDATNFSTRFAGEVKGFNVE
CCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCCCCHH
EYIPAKEARHMDTFIHYGIAAGMQAMQDSGFQVTDENAERVGVVVGSGIGGLPMIEVTQT
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCCEEEEHHH
ELLNRGPRRISPFFVPASIINMISGHLSIKFGIKGPNLAIVTACTTGLHCIGEAARLIEY
HHHCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHEE
GDADVMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAEVAGYGMSGDAYHMTAPLENGDGARRCMLAALRNAGVNADQVNY
EECCHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEE
LNAHGTSTPLGDLAETVAIKRAFGDHSKDIVVNSTKSMTGHLLGGAGGLESVFTVLAVHN
EECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHC
QVSPPTINIFNQDPECDLDYCANEAREMKIDVALKNSFGFGGTNGTLVFKRA
CCCCCEEEEECCCCCCCHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIVNITKFDATNFSTRFAGEVKGFNVE
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCCCCHH
EYIPAKEARHMDTFIHYGIAAGMQAMQDSGFQVTDENAERVGVVVGSGIGGLPMIEVTQT
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCCCCEEEEHHH
ELLNRGPRRISPFFVPASIINMISGHLSIKFGIKGPNLAIVTACTTGLHCIGEAARLIEY
HHHCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHEE
GDADVMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAEVAGYGMSGDAYHMTAPLENGDGARRCMLAALRNAGVNADQVNY
EECCHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEE
LNAHGTSTPLGDLAETVAIKRAFGDHSKDIVVNSTKSMTGHLLGGAGGLESVFTVLAVHN
EECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHC
QVSPPTINIFNQDPECDLDYCANEAREMKIDVALKNSFGFGGTNGTLVFKRA
CCCCCEEEEECCCCCCCHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]