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The map label for this gene is atoC [H]

Identifier: 237813189

GI number: 237813189

Start: 2877443

End: 2878840

Strand: Direct

Name: atoC [H]

Synonym: GBP346_A2954

Alternate gene names: 237813189

Gene position: 2877443-2878840 (Clockwise)

Preceding gene: 237813187

Following gene: 237813212

Centisome position: 70.21

GC content: 69.96

Gene sequence:

>1398_bases
ATGCCACACGCCCTGATTGTCGAAGACGATCCCAATAGCTTATCCGGCCTGACCGCGCTCCTCGGCGCGGACGGCTTCTC
GGTCGATACGGCGACCTCGCTCGCCGAAGCGCGCGGCGCCCTCGCCCGCTCGATTCCCGATGTCGTCCTCGTCGACCTGA
ACCTGCCCGACGGCAGCGGCTTCGATCTGCTGCAGAACCTGCCGCAGCAGCAGCCGAACGGTTCGCTGCCGGTGATCGTG
CTGACCGGCAACGCGACCGTCGAAAGCGCGATCGAGGGGCTGCGGCACGGCGTCTGGGATTACCTGCTGAAGCCCGTCAA
CATCCCGCGGCTGCGCAGCCTGCTCGCGCGAATCCCTCGCCCGTACGAGCTGATCGAGGAAGTGCAGGCGCTGCGCGCGA
CGCTGCGCCGCCTCGGCCGCTTCGGCTCGCTCGTCGGGCGCAGCGATGCGATCCAGCACGTCTACGACATGATCGAGCAC
AACGCCCGCACCGAAACCGCGGTGCTGTTGTGGGGCGAGCCCGGCACCGGCAAGGAAGCGGCCGCGCGCACGCTGCATGA
GCTGAGCCGCCGCCGCAAGGGCCCGTTCATCGCGTTCGACTGCCGCGCCGCCGTGCAGTCGCCGCGCAACATCGAGACCA
ACGGCCGCGCGATCGAAAGCATGCTGCTCGGCCGCGAGCGCGGCGCGTACACGGGCGTCGAGCGGCGCGATCCCGGCCTC
TTCGAGCAGGCGAGCGGCGGCACGCTGTTGCTCGGAGAAATCACCGCGCTGCCGCTGTCGCTGCAGGAGGCGCTGCTGCG
CGCGCTCGATTCGCAGAACTTCATGCGCGTCGGCGGCACGACCGAAATCGCGAGCGACTTCCGGCTGATCGCAACGACGC
GCCGCCCCGCGCGCGAAGCGGTCGCGAACGGCACGCTGCGCGAGGATCTGTGGCTGCGGCTCGATGCCGCATCGATCGGC
CTGCCGCCGCTGCGCGAACGCGACGACGACGTCGTCGTCATGGCCGAGGCGTTCGTCGACGATCTGAACCGCGACGCACG
CACGGCGGGCCTGAACATCACCGACAAGCGGCTCGCGCCCGGCTTCATTCGCGAATGCCTCGCGTACGACTGGCCGGGCA
ACGTGCGCGAGCTGCAAGAGCGGGTGCGGATCGCATACGATCAGTCGGGCGATTTCATCGAGACGCTGCGCGCGGGCGAC
GCGTATCCGCAGCCCGGCGCGGCGCTGAACGGCAGCAGCGTGCAGGTGCGCGTCGGCACGCCGCTCGCCGACGTCGAGGA
TCTGCTGATCCGCGCGACGCTCGACGCGGTCGGCGGCACGCGCCACCGCGCGGCGACGCTGCTCGGCATCAGCCCGAAGA
CGCTCTACAACAAGCTGCAGCGCATGAAGATCGGCTGA

Upstream 100 bases:

>100_bases
ACGCCAAGTGCGCGATGGGGCATAAAATTCATTTCTCATCCCGAAATGGGGGCCGTACGCCGGTCCGGCTGATGGACCGG
TCTTTCAACTCGCGCACACC

Downstream 100 bases:

>100_bases
CGCCCGCACGCGGCGAACGAGCCGCCGCGCCGCCCCGTGCGTCGGCTGCGTTTCGCCTTCATCGCGCCTTCGCTGCGCCC
TCTCCCGTCTTCGGCTGCCG

Product: sigma-54 dependent DNA-binding response regulator, Fis family

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSGFDLLQNLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPRPYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEH
NARTETAVLLWGEPGTGKEAAARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGL
FEQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREAVANGTLREDLWLRLDAASIG
LPPLRERDDDVVVMAEAFVDDLNRDARTAGLNITDKRLAPGFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGD
AYPQPGAALNGSSVQVRVGTPLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG

Sequences:

>Translated_465_residues
MPHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSGFDLLQNLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPRPYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEH
NARTETAVLLWGEPGTGKEAAARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGL
FEQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREAVANGTLREDLWLRLDAASIG
LPPLRERDDDVVVMAEAFVDDLNRDARTAGLNITDKRLAPGFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGD
AYPQPGAALNGSSVQVRVGTPLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG
>Mature_464_residues
PHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSGFDLLQNLPQQQPNGSLPVIVL
TGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPRPYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEHN
ARTETAVLLWGEPGTGKEAAARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGLF
EQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREAVANGTLREDLWLRLDAASIGL
PPLRERDDDVVVMAEAFVDDLNRDARTAGLNITDKRLAPGFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGDA
YPQPGAALNGSSVQVRVGTPLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=467, Percent_Identity=34.475374732334, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1790437, Length=462, Percent_Identity=34.8484848484849, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=33.8204592901879, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788905, Length=378, Percent_Identity=33.8624338624339, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082117, Length=352, Percent_Identity=35.2272727272727, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=34.6938775510204, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87081872, Length=244, Percent_Identity=39.7540983606557, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1789233, Length=338, Percent_Identity=32.2485207100592, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786524, Length=340, Percent_Identity=34.4117647058824, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87082152, Length=298, Percent_Identity=33.2214765100671, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787583, Length=273, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789828, Length=277, Percent_Identity=32.4909747292419, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=28.5245901639344, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786838, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=117, Percent_Identity=36.7521367521368, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787229, Length=123, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50646; Mature: 50515

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSG
CCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
FDLLQNLPQQQPNGSLPVIVLTGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEHNARTETAVLLWGEPGTGKEA
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGL
HHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
FEQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREA
CCCCCCCEEEEEHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHHCCEEEEECCCHHHHH
VANGTLREDLWLRLDAASIGLPPLRERDDDVVVMAEAFVDDLNRDARTAGLNITDKRLAP
HHCCCHHHHHEEEEEHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCHHHCCCCCCHHHCCH
GFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGDAYPQPGAALNGSSVQVRVGT
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECC
PLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG
CHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSG
CCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
FDLLQNLPQQQPNGSLPVIVLTGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEHNARTETAVLLWGEPGTGKEA
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGL
HHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
FEQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREA
CCCCCCCEEEEEHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHHCCEEEEECCCHHHHH
VANGTLREDLWLRLDAASIGLPPLRERDDDVVVMAEAFVDDLNRDARTAGLNITDKRLAP
HHCCCHHHHHEEEEEHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCHHHCCCCCCHHHCCH
GFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGDAYPQPGAALNGSSVQVRVGT
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEECC
PLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG
CHHHHHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]