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The map label for this gene is cyoB_1 [H]

Identifier: 237813133

GI number: 237813133

Start: 2822572

End: 2824578

Strand: Direct

Name: cyoB_1 [H]

Synonym: GBP346_A2895

Alternate gene names: 237813133

Gene position: 2822572-2824578 (Clockwise)

Preceding gene: 237813132

Following gene: 237813134

Centisome position: 68.87

GC content: 64.08

Gene sequence:

>2007_bases
ATGTTCGGTAAATTGACGCTTTCCGCCATCCCGTTCGATCAGCCGATCGTCATGGGCGCCGCCGCGCTCATGGCGCTCGT
CGCGCTGTCGGTCGTGGGCGCGCTCACCTACACGAAGCGCTGGAAATGGCTGTGGTGCGAGTGGCTCACGTCGGTCGATC
ACAAGAAAATCGGCGTGATGTACATCGTCGTCGCGGTGCTGATGCTGCTGCGCGGCTTCGCTGACGCGGTGATGATGCGC
CTGCAGCTCGCGCTCGCGTACAACGGGCCCGGCTATCTGCCGCCGCACCACTACGACCAGATCTTCACCGCGCACGGCGT
CATCATGATCTTCTTCATGGCGATGGCGCTGCTCGTCGGGCTCTTCAACCTGATCGTGCCGCTGCAGATCGGCGCGCGCG
ACGTCGCCTTCCCGTTCCTGAACTCGCTGAGTTTCTGGATGACGGCCGTCGCCGCGCTGCTGATGAACGTGTCGCTCGTC
GTCGGCGAATTCGCGCAGACGGGCTGGCTCGCGTATCCGCCGCTCTCGGAGCTGCAGTTCAGTCCGGGCGTCGGCGTCGA
CTATTACCTGTGGGCGCTGCAGATATCCGGCGTCGGCACGCTGATCACCGCGATCAACTTCTTCGTGACGATCATCCGGA
TGCGCGCGCCCGGCATGACGCTGATGAAGATGCCGGTATTCACGTGGACGGCGCTTTGCTCGAACGTGCTGATCATGGCG
ACATTCCCGATCCTGACGGTCGCGCTCGCCCTCCTCGCGCTCGATCGCTACCTCGGCATGCACTTCTTCACGAACGACGC
CGGCGGCAACGCGATGGTCTACCTGAATTTGATCTGGGCGTGGGGCCACCCCGAGGTGTACATCCTCGTGCTGCCCGCGT
TCGGCATCTATTCGGAAGTGATCGCGACGTTCTCGAAGAAGCCGCTGTTCGGCTACAAGACGATGGTCTACGCGTCGTGC
GTGATCATGGTGCTCGCGTTCCTCGTGTGGCTGCACCACTTCTTCACGATGGGCTCGGGCGCGAACGTGAACGCGTTCTT
CGGAATTATGACGATGGTGATCGCGATCCCGACCGGCGTGAAGATCTTCAACTGGCTGTTCACGATGTACCGCGGCCGCA
TCGAATTCACCGCGCCCGTGCTGTGGACGATCGGCTTCATGGTGACGTTCACGCTCGGCGGGATGACGGGCGTGATGATG
GCGATTCCGGGCGCGGACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCGCATTTCCACAACGCGATCATCGGCGGCGT
CGTGTTCGGCTATCTCGCCGGCTTCCATTACTGGTTTCCGAAGGCGTTCGGCTTCAAGCTCGACGAGAAGCTCGGCAAGC
GCGCGTTCTGGTGCTGGTTCATCGGCTTTTACGTGTCGTTCGTGCCGCTGTACGTGCTCGGTTTCATGGGCATGACGCGC
CGCCTGAACCATTACGACAACCCCGCCTGGCATCCGTGGCTCATCGTCGCCGCGTGCGGCGTCGCGTTGATCGCGCTCGG
CGTGCTGCACCAGGTCGCGCAGGTGTGGGTGGCGGTGCGCAATCGCAACGCGCCCGGCTACCGCGACACGACGGGCGACC
CGTGGGACGGCCGCACGCTCGAATGGGCGACGGCCTCGCCGCCGCCCGTCTACAACTTCGCGGTGATCCCGACCGTGCAC
GCGCTCGACGAGCTCGCGTACCGCAAGGAGCACGGCATCGGCGTCGGCAAGAACGCCGTCTATCAGGACATCCACATGCC
GTCGAACACCAGCGCGGGCTTGTTCGTCGGCATGTTCAGCCTCGTGCTCGGCTTCGCGCTCGTGTGGCACATCTGGTGGC
TCGCGATCGCAGCGTTCGTCGGCATCGTCGCGACGGTGGTGCTGTACAGCGCGGGCGAGAACGACGGCTATTACATTGCG
GCCGACACCGTCCGCGAGATCGAGGAAAGGCGCGCCGGCGCGCGCGCGCCGGCGCGGCCGGCCGAAGTCGAACTGGAGGC
AAACTGA

Upstream 100 bases:

>100_bases
GACGGTCGATCCTCGGCTCTTCAATAACATCATCGCGAAGTACAACAACGGCCACGTCCTCGATCTGAAGGACGCCGCCT
GTCGGACGAAGGGGTAATGC

Downstream 100 bases:

>100_bases
TGTCGCACAACACGATGATGCTCGACCACGCGGCCTCGCACGATCATCCGCCGTCGCATTCGGTGTTCGGCTTCTGGCTG
TACCTGATGACCGACTGCGT

Product: cytochrome o ubiquinol oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVMYIVVAVLMLLRGFADAVMMR
LQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVGLFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLV
VGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMA
TFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEVIATFSKKPLFGYKTMVYASC
VIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGVKIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTR
RLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTLEWATASPPPVYNFAVIPTVH
ALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFSLVLGFALVWHIWWLAIAAFVGIVATVVLYSAGENDGYYIA
ADTVREIEERRAGARAPARPAEVELEAN

Sequences:

>Translated_668_residues
MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVMYIVVAVLMLLRGFADAVMMR
LQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVGLFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLV
VGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMA
TFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEVIATFSKKPLFGYKTMVYASC
VIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGVKIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTR
RLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTLEWATASPPPVYNFAVIPTVH
ALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFSLVLGFALVWHIWWLAIAAFVGIVATVVLYSAGENDGYYIA
ADTVREIEERRAGARAPARPAEVELEAN
>Mature_668_residues
MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVMYIVVAVLMLLRGFADAVMMR
LQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVGLFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLV
VGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMA
TFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEVIATFSKKPLFGYKTMVYASC
VIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGVKIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTR
RLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTLEWATASPPPVYNFAVIPTVH
ALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFSLVLGFALVWHIWWLAIAAFVGIVATVVLYSAGENDGYYIA
ADTVREIEERRAGARAPARPAEVELEAN

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=39.4891944990177, Blast_Score=345, Evalue=7e-95,
Organism=Escherichia coli, GI1786634, Length=652, Percent_Identity=66.2576687116564, Blast_Score=905, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=37.9888268156425, Blast_Score=356, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.7692307692308, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=34.9593495934959, Blast_Score=141, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74186; Mature: 74186

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVM
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIVVAVLMLLRGFADAVMMRLQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLVVGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMA
CCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
TFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCEEEEEECCHHHHHHH
IATFSKKPLFGYKTMVYASCVIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEHHCCCCEEHHHH
NAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATASPPPVYNFAVIPTVHALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFS
EECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHH
LVLGFALVWHIWWLAIAAFVGIVATVVLYSAGENDGYYIAADTVREIEERRAGARAPARP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCC
AEVELEAN
CCEEEECC
>Mature Secondary Structure
MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVM
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIVVAVLMLLRGFADAVMMRLQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLVVGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMA
CCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
TFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCEEEEEECCHHHHHHH
IATFSKKPLFGYKTMVYASCVIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEHHCCCCEEHHHH
NAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATASPPPVYNFAVIPTVHALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFS
EECCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHH
LVLGFALVWHIWWLAIAAFVGIVATVVLYSAGENDGYYIAADTVREIEERRAGARAPARP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCC
AEVELEAN
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]