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The map label for this gene is phrB [H]

Identifier: 237813094

GI number: 237813094

Start: 2788733

End: 2790193

Strand: Reverse

Name: phrB [H]

Synonym: GBP346_A2856

Alternate gene names: 237813094

Gene position: 2790193-2788733 (Counterclockwise)

Preceding gene: 237813096

Following gene: 237813093

Centisome position: 68.08

GC content: 74.33

Gene sequence:

>1461_bases
TTGTCTTCATCCATCTCGATTGCGCCCGCCGTCGTCTGGTTTCGCGACGATCTGCGCGTGTCCGATCATCCCGCGCTCAT
GCGCGCCGCCGAGTCGGGGCGCCCCGTGATCGGCGTCTACGTGTTCGACGAGCGCGTCGGCGGGCGGCCGCTGGGCGGCG
CGGCGCGCTGGTGGCTGCACGGCTCGTTGCGCGCGCTCGGCGCGGCGCTCGCCGCGCTGGGCGGCACGCTCGCGCTGCTG
CGCGGTGACGAGCACGATACGATCGTTTCGTTCGCCGCGGCGCTCGGCGCGGGCGCCGTCTACTGGAGCCGCCGCTATGC
GCTTGCCGCGCGCGCGGTCGACAACGCGGTGCAGACGGCGCTCGACGCGCAGGGCATCGCGGTCGAGACGTTCAACGCGA
GCCTGCTGTTCGAGCCGGGCGACCTCGTCAACGCGGACGGCCGCCCGTATCAGGTGTTCAGCGCGTACTGGCGCGCGGCG
ATGCGCCGCGGCGTGCCGGCACCGCCGCTCGGCGCGCCGCGGCGCCTGAACGGCGGCGCGCTGCCGGCGGCGCTCGCGCG
GCAGTGCGTGGCGCTCGACGCGCTCGGGCTCGAGCCGACGGGCCCGGACTGGGCGGGCGGCCTGCGCGACGCATGGCGTT
TCGGCGAGGACGCCGCGCACCGTCGGCTGCGCGCCTTCGTCGACAGCCGGCTCGGCGGCTATGCGGCCGAGCGCGACCGG
CCGGGCATCGCGTCGACGAGCCGGCTGTCGCCGTACGTGCGCTTCGGCAACCTGTCGGCGCGGCAGCTCTGGCATGCGGC
CGCCGACGCGTACGCGCACGGCGCGGCGACCCAGGCGGACCTCGACAAGTTTCTGAGCGAGCTCGGCTGGCGGGAGTTCG
GCTGGACCCAGTTGCACCACTTTCCGGACCTGCCGCGCCGCAACCTGCGCCACACGCTCGACGGCATGCCGTGGCGCGAC
GATCCCGCCGCGCTTGCCGCATGGCGGCGCGGCGCCACGGGCTATCCGTTCGTCGACGCCGGCATGCGCGAGCTCTGGGC
GACGGGCTGGATGCACAACCGCGTGCGGATGGTATGCGCTTCGTTTCTCGTCAAGCACTTGCTGATCGACTGGCGGGCGG
GCGAGGCGTGGTTCTGGGACACGCTCGTCGACGCGGACGCGGCGTCGAACGCCGCGAACTGGCAGTGGGTCGCGGGCTGC
GGCGCGGATGCCGCGCCGTATTTCCGGATCTTCAATCCGGTCGCGCAGGGCCGGAAGTTCGATCCGGACGGCGCCTATGT
GCGGCGCTGGGTGCCCGAGCTGGCCGGCCTGCCGCCCGCGACGATCCACGAGCCGTGGGCGGCGCCCGGCGCGCAGCTCG
CCGCGGCGGGCGTGCGGCTCGGCGAGACTTATCCGCTGCCGATCGTCGCGCACGACGCCGCGCGCCGGCGAGCGCTCGAC
GCATTCGGGGCAATCAGATGA

Upstream 100 bases:

>100_bases
TCGTCCGCCGAGCGTATTCGATCGGCCGGCGCCGCGCCTGCCGCGATACGGCCGGGCAGCGCCGGCCGTGTTTCGTCGGC
TTTTCATCGGAGCCCTTCCA

Downstream 100 bases:

>100_bases
ATCCTGTTCTGGCGCATTTAATCGTTCGTAATGGATATCGCTGAAATATTCAGAAAAGGTCAGATTTTTGATCTTTTTCA
GTTGTTAAACTCTCGCTTTG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERVGGRPLGGAARWWLHGSLRALGAALAALGGTLALL
RGDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTALDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAA
MRRGVPAPPLGAPRRLNGGALPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDR
PGIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHHFPDLPRRNLRHTLDGMPWRD
DPAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCASFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGC
GADAAPYFRIFNPVAQGRKFDPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALD
AFGAIR

Sequences:

>Translated_486_residues
MSSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERVGGRPLGGAARWWLHGSLRALGAALAALGGTLALL
RGDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTALDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAA
MRRGVPAPPLGAPRRLNGGALPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDR
PGIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHHFPDLPRRNLRHTLDGMPWRD
DPAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCASFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGC
GADAAPYFRIFNPVAQGRKFDPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALD
AFGAIR
>Mature_485_residues
SSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERVGGRPLGGAARWWLHGSLRALGAALAALGGTLALLR
GDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTALDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAAM
RRGVPAPPLGAPRRLNGGALPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDRP
GIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHHFPDLPRRNLRHTLDGMPWRDD
PAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCASFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGCG
ADAAPYFRIFNPVAQGRKFDPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALDA
FGAIR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=493, Percent_Identity=30.0202839756592, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI4758072, Length=494, Percent_Identity=28.3400809716599, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI188536103, Length=450, Percent_Identity=29.1111111111111, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1786926, Length=495, Percent_Identity=36.5656565656566, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324962, Length=523, Percent_Identity=26.7686424474187, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17137248, Length=499, Percent_Identity=30.4609218436874, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24585455, Length=499, Percent_Identity=30.4609218436874, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24648152, Length=516, Percent_Identity=25.5813953488372, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52842; Mature: 52711

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERVGGRPLGGAARWWLH
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
GSLRALGAALAALGGTLALLRGDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTA
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAAMRRGVPAPPLGAPRRLNGGA
HCCCCCEEEEECCEEEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDR
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
PGIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHH
CCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHC
FPDLPRRNLRHTLDGMPWRDDPAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCA
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGCGADAAPYFRIFNPVAQGRKF
HHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCC
DPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHH
AFGAIR
HHHCCC
>Mature Secondary Structure 
SSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERVGGRPLGGAARWWLH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
GSLRALGAALAALGGTLALLRGDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTA
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAAMRRGVPAPPLGAPRRLNGGA
HCCCCCEEEEECCEEEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDR
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
PGIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHH
CCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHC
FPDLPRRNLRHTLDGMPWRDDPAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCA
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGCGADAAPYFRIFNPVAQGRKF
HHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCC
DPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHH
AFGAIR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]