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The map label for this gene is alsR [H]

Identifier: 237813069

GI number: 237813069

Start: 2766693

End: 2767595

Strand: Direct

Name: alsR [H]

Synonym: GBP346_A2830

Alternate gene names: 237813069

Gene position: 2766693-2767595 (Clockwise)

Preceding gene: 237813064

Following gene: 237813076

Centisome position: 67.5

GC content: 67.0

Gene sequence:

>903_bases
ATGGACCTCAAGCAATTGCGCTACTTCGTCGCCGTCGCGGAAGAGCTGCATTTCGGCCGTGCGGCGAAACGGCTGTTCAT
CTCGCAGCCGGCCTTGAGCTTCGATATCCGCAAGTTCGAGGACGAGCTCGGCGTGCAACTGCTCGCGCGCACGAGCAAGT
CGGTCGCGCTGACGAATGCGGGCGAAGTGCTGCTCGGCGAGGCGCGCCGCCTGCTGCTGCAGGCGCAGGAAGCGCAGCGT
CTGACGATTCGATCGGCATCGGGGCTCGCGGGGCGGCTGAAGATCGGCTTCGTCAATTCGATGCTGTACCGCGGGCTGCC
TTCGGCGGTACGGCGTTTCGAGGCGGACTATCCGAATGTCGAAGTCGTGCTGAAGGAGATGAACACGCACGAGCAGGCGC
AAGCGATCCTGCGCGCGCAGATCGACGTCGGCTACGCGCACTGGGGCACGTTCCCGCCGGAGATCGCGGTCGACACGATC
CTCTCCGAGCCGTTCCTCTGCTGCCTGCCCGCGACGCATCGGCTCGCGCGGCGCAGGCGCGTCGATCTCGCGGCGCTCGC
GCACGAGCCGTTCATCCTGTTCCCGCGCGATGCGGCGCCCCACTATCACGATCTCATCATCGCGCAGTGCGTGAGCGCGG
GCTTCAGTCCGCAGATCCGTCACGAGGCGCGCCTCTGGCAGACGGTGCTGACGATGGTCGAGTTCGAGATGGGAGTGGCG
CTCGTGCCGAGCGTGCTGCGCGAGGTGCGCAGCGAGCGGCTGCGCTACCTGCCGCTCGCCGGCGACGCGCTTGAATCCCG
CACGTTGCGGTTGCGGCGCTCGAATGAACGGGAGCCGGTTGCGGAGTGCTTCGGCGAATATCTGGACGACGAGATCCGGC
GGCTTCGCGGTGCGGCAGAGTGA

Upstream 100 bases:

>100_bases
TCCTGGTCCGACGAGCGTAGAACCGCGATCGATAATCGTCCAATACAGGATTTATCCAGTACGATAAACGCTATTTATCG
ATTGCCAGAATGGAGGCGCG

Downstream 100 bases:

>100_bases
CGGCGCGCGGGCGGGTGCTCAAAAAAGTTCTGGATAAAAGTGCGCGATTGCCGGTAGAATCACGCCCCTGGTCGCGCAAT
GTGTGACCGGCACCCGTCGG

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDLKQLRYFVAVAEELHFGRAAKRLFISQPALSFDIRKFEDELGVQLLARTSKSVALTNAGEVLLGEARRLLLQAQEAQR
LTIRSASGLAGRLKIGFVNSMLYRGLPSAVRRFEADYPNVEVVLKEMNTHEQAQAILRAQIDVGYAHWGTFPPEIAVDTI
LSEPFLCCLPATHRLARRRRVDLAALAHEPFILFPRDAAPHYHDLIIAQCVSAGFSPQIRHEARLWQTVLTMVEFEMGVA
LVPSVLREVRSERLRYLPLAGDALESRTLRLRRSNEREPVAECFGEYLDDEIRRLRGAAE

Sequences:

>Translated_300_residues
MDLKQLRYFVAVAEELHFGRAAKRLFISQPALSFDIRKFEDELGVQLLARTSKSVALTNAGEVLLGEARRLLLQAQEAQR
LTIRSASGLAGRLKIGFVNSMLYRGLPSAVRRFEADYPNVEVVLKEMNTHEQAQAILRAQIDVGYAHWGTFPPEIAVDTI
LSEPFLCCLPATHRLARRRRVDLAALAHEPFILFPRDAAPHYHDLIIAQCVSAGFSPQIRHEARLWQTVLTMVEFEMGVA
LVPSVLREVRSERLRYLPLAGDALESRTLRLRRSNEREPVAECFGEYLDDEIRRLRGAAE
>Mature_300_residues
MDLKQLRYFVAVAEELHFGRAAKRLFISQPALSFDIRKFEDELGVQLLARTSKSVALTNAGEVLLGEARRLLLQAQEAQR
LTIRSASGLAGRLKIGFVNSMLYRGLPSAVRRFEADYPNVEVVLKEMNTHEQAQAILRAQIDVGYAHWGTFPPEIAVDTI
LSEPFLCCLPATHRLARRRRVDLAALAHEPFILFPRDAAPHYHDLIIAQCVSAGFSPQIRHEARLWQTVLTMVEFEMGVA
LVPSVLREVRSERLRYLPLAGDALESRTLRLRRSNEREPVAECFGEYLDDEIRRLRGAAE

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=295, Percent_Identity=36.271186440678, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI2367136, Length=244, Percent_Identity=40.9836065573771, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=33.2179930795848, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790399, Length=265, Percent_Identity=31.6981132075472, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI157672245, Length=283, Percent_Identity=30.7420494699647, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=29.7959183673469, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=29.2181069958848, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790208, Length=286, Percent_Identity=28.6713286713287, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787601, Length=175, Percent_Identity=31.4285714285714, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788297, Length=153, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787530, Length=258, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788481, Length=199, Percent_Identity=29.6482412060301, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789173, Length=174, Percent_Identity=31.6091954022989, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994962, Length=80, Percent_Identity=43.75, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=197, Percent_Identity=25.8883248730964, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082132, Length=144, Percent_Identity=28.4722222222222, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.9672131147541, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=35.7723577235772, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790262, Length=301, Percent_Identity=24.5847176079734, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33969; Mature: 33969

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQLRYFVAVAEELHFGRAAKRLFISQPALSFDIRKFEDELGVQLLARTSKSVALTNA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GEVLLGEARRLLLQAQEAQRLTIRSASGLAGRLKIGFVNSMLYRGLPSAVRRFEADYPNV
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEHHHHHHHHHHCCHHHHHHHCCCCCCH
EVVLKEMNTHEQAQAILRAQIDVGYAHWGTFPPEIAVDTILSEPFLCCLPATHRLARRRR
HHHHHHHCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHH
VDLAALAHEPFILFPRDAAPHYHDLIIAQCVSAGFSPQIRHEARLWQTVLTMVEFEMGVA
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVPSVLREVRSERLRYLPLAGDALESRTLRLRRSNEREPVAECFGEYLDDEIRRLRGAAE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLKQLRYFVAVAEELHFGRAAKRLFISQPALSFDIRKFEDELGVQLLARTSKSVALTNA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GEVLLGEARRLLLQAQEAQRLTIRSASGLAGRLKIGFVNSMLYRGLPSAVRRFEADYPNV
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEHHHHHHHHHHCCHHHHHHHCCCCCCH
EVVLKEMNTHEQAQAILRAQIDVGYAHWGTFPPEIAVDTILSEPFLCCLPATHRLARRRR
HHHHHHHCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHH
VDLAALAHEPFILFPRDAAPHYHDLIIAQCVSAGFSPQIRHEARLWQTVLTMVEFEMGVA
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVPSVLREVRSERLRYLPLAGDALESRTLRLRRSNEREPVAECFGEYLDDEIRRLRGAAE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]