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The map label for this gene is argA [H]

Identifier: 237813063

GI number: 237813063

Start: 2759838

End: 2761214

Strand: Direct

Name: argA [H]

Synonym: GBP346_A2824

Alternate gene names: 237813063

Gene position: 2759838-2761214 (Clockwise)

Preceding gene: 237813058

Following gene: 237813064

Centisome position: 67.34

GC content: 69.06

Gene sequence:

>1377_bases
ATGAATTCCCAAACCGACCTTCCCGCCGCCCAGTCGGGCGCCGCGCCCCAGCCGTCCGTCGACGAAGCCGTCCATCACGC
GCAGTTCGTCGACTGGATGCGCTCCGTCGCGCCCTATATCCACAAGTTCCGCAACAGCACCTTCGTGGTCGGCTTCGGCG
GCGAGGTCGTGCAGCACGGGCTGCTGAGCGCGCTCGTCTCCGACATCGCGCTGCTGCAGGCGATGGGCATCCAGATCGTG
CTCGTGCACGGCTCGCGGCCGCAGGTCGAGGAGCAACTGCACCTGCACGGCGTCGAATCGGCGTTCTCGCACGGCCTGCG
GATCACCGACGCGCGCGCGCTCGAATCGGCGAAGGAAGCGGCGGGCGAAGTGCGGCTCGACATCGAGGCGGCGATCAGCC
AGGGCTTGCCGAACACGCCGATGGCGCACGCGCACATCAGCGTCGTGTCGGGCAACTTCGTGACGGCGCGCCCGGTCGGG
ATTCTCGACGGCGTCGATTTCGCGCACACGGGCGTCGTGCGCAAGATCGATGCCGAGTCGATCCGCCACTCGCTCGCGAG
CCGCAAGCTCGTGCTGCTGTCGCCGCTCGGCTTCTCGCCGACGGGCGAGGCGTTCAACCTGTCGATGGAGGATGTCGCGT
CGGCGGCCGCGATCGCGCTGCGCGCGGACAAGATCATCTTCCTGACCGAATCGCCCGGCATCGTCGACGAAGCGGGCGAG
CTCGTGCGCGAGATGTCGCTCGACGCGGCGGCCGAACTGCTCGACTCGGGCGATCTGCAAGGCGACGACGGGTTCTTCCT
GAAGCACGCGATCCGCGCGTGCCGCGGCGGCGTCGCGCGCGCGCACCTGATACCGCAGTCGCTCGACGGCAGCGTGCTGC
TCGAGCTGTTCCTGCACGACGGCGTGGGCACGATGATCTCGTACGAGAACCTCGAGAGCCTGCGCGAGGCGACGCCGGAC
GACGTGGGCGGCATCCTGACCCTCATCGAGCCGCTCGAGACGGACGGCACGCTCGTGCGGCGCGGCCGCCACCAGATCGA
GCGCGACATCGATCACTTCTCGGTCATCGAGCACGACGGCGTGCTGTTCGGCTGCGCGGCGCTCTATCCGTACCCGACCG
AGAAGATCGGCGAGATGGCGTGCCTCACGGTCGCGCCCGAGGCGCAGGGCTCGGGCGACGGCGAGCGGCTCCTCAAGCGG
GTCGAGCAGCGCGCCCGCGCGCGCGGCCTCACGCGGATCTTCGTGCTGACGACGCGCACCGAGCACTGGTTCCTCAAGCG
CGGCTTCGTGAAGGCGACGGTCGACGACCTGCCCGAGGACCGCCGCAAGCTCTATAACTGGCAGCGCAAGTCGCTCGTGC
TGATGAAGCAGCTCTGA

Upstream 100 bases:

>100_bases
GCAGCGGCGCCGGCGGGCTGCGGCTCGCCCGGCGTGCCCGCACGTTTTTGCGCGGGACTTTTAGGTACATTCGACATGGG
GGCGCATTATAATCCCGCCC

Downstream 100 bases:

>100_bases
GCGGCGCCGCGCGCCCTTCCCCCCCGGATTACGATTACAGGAGAGGTACACGATGGCCCGTATGATCCACTGCGCGAAGC
TCGGCAAGGAAGCCGAGGGA

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHGLLSALVSDIALLQAMGIQIV
LVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEAAGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVG
ILDGVDFAHTGVVRKIDAESIRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGE
LVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHDGVGTMISYENLESLREATPD
DVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDGVLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKR
VEQRARARGLTRIFVLTTRTEHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL

Sequences:

>Translated_458_residues
MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHGLLSALVSDIALLQAMGIQIV
LVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEAAGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVG
ILDGVDFAHTGVVRKIDAESIRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGE
LVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHDGVGTMISYENLESLREATPD
DVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDGVLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKR
VEQRARARGLTRIFVLTTRTEHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL
>Mature_458_residues
MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHGLLSALVSDIALLQAMGIQIV
LVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEAAGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVG
ILDGVDFAHTGVVRKIDAESIRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGE
LVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHDGVGTMISYENLESLREATPD
DVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDGVLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKR
VEQRARARGLTRIFVLTTRTEHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Escherichia coli, GI1789181, Length=436, Percent_Identity=46.5596330275229, Blast_Score=423, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320913, Length=285, Percent_Identity=25.9649122807018, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167 [H]

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1 [H]

EC number: =2.3.1.1 [H]

Molecular weight: Translated: 49792; Mature: 49792

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
LLSALVSDIALLQAMGIQIVLVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEA
HHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
AGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVGILDGVDFAHTGVVRKIDAES
CCCEEEEHHHHHHCCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCHHHCCHHHCCCHHH
IRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGE
HHHHHHHCCEEEEECCCCCCCCCEEECCHHHHHHHHHHEEECCEEEEEECCCCCHHHHHH
LVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHD
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHC
GVGTMISYENLESLREATPDDVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDG
CCCHHEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCC
VLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKRVEQRARARGLTRIFVLTTRT
EEEEHHHHCCCCHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
EHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
LLSALVSDIALLQAMGIQIVLVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEA
HHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
AGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVGILDGVDFAHTGVVRKIDAES
CCCEEEEHHHHHHCCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCHHHCCHHHCCCHHH
IRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGE
HHHHHHHCCEEEEECCCCCCCCCEEECCHHHHHHHHHHEEECCEEEEEECCCCCHHHHHH
LVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHD
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHC
GVGTMISYENLESLREATPDDVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDG
CCCHHEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCC
VLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKRVEQRARARGLTRIFVLTTRT
EEEEHHHHCCCCHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
EHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]