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The map label for this gene is prlC [H]

Identifier: 237813038

GI number: 237813038

Start: 2728123

End: 2730222

Strand: Direct

Name: prlC [H]

Synonym: GBP346_A2798

Alternate gene names: 237813038

Gene position: 2728123-2730222 (Clockwise)

Preceding gene: 237813036

Following gene: 237813040

Centisome position: 66.56

GC content: 68.24

Gene sequence:

>2100_bases
ATGTCCGTCAGCGCAAACGCCAACCCGCTTCTCGATTTCTCAGGCCTGCCCCGCTTCGGCGAAATTCGCCCCGAACACGT
GACGCCCGCGCTCGATACGCTGCTCGCGAACGCAAACGACGCAGTCGAGCAAGCCGCGCGGCCCGACACGCCCGCGACCT
GGGCCGATGTCGTCGAGACCATCGAGCAGGCGACCGAGCCGCTCGGCCGCGCGTGGGGCGTCGTCGGCCATCTGAACGCG
GTCGCCGACACGCCCGAGCTGCGCGCCGTCTACGGCGAGAACCTGCCGCGCGTGACCGAGTTCTGGTCGAGCGTCGGCCA
GAATCTCGCGCTCTACGAAAAGTACAAGGCGATCGCCGCGAGCCCCGAATACGCCGCGCTGTCCGCCGAGCGCAAGAAGA
TCCTCGACAACGCGCTGCGCGACTTCCGCCTGTCGGGCGCCGAGCTGCCAGAGGACCACAAGCCGCGCTTCGCTCAGTTG
CAGGAGCAGCAGGCGGCGCTGTCGAAGTCGTTCTCCGATCACGTGCTCGACGCGACGAACGGCTACGCGTACTACGCGCG
CAGCGAGGACGAACTGGCCGGCCTGCCCGACGACGCGATCGCGGCCGCGCGCGAGGCCGCGCGAAAGGAAGACAAGGCCG
GCTGGAAGTTCACGCTGCACTTCCCGTCGTATTTCCCGGTGCTGCAATACGCGCGGAACCGCGCGATGCGCGAGGCGATG
TATCGCGCGTACGTGACGCGCGCGTCCGAGCTCGGCCCGCAGTACGGCGACGGCAAGGCCGACTGGGACAACACGACGAT
CATCGCGGATCAGCTCGCGCTGCGCCGCGAAGAGGCGACGATGCTCGGCTATCACGACTTCGCCGAAGTGTCGCTCGCGC
CGAAGATGGCGGAATCGCCGCAGCAGGTGATCGCGTTCCTCGAGGATCTCGCGAAGCGCGCGCGCCCGTTCGCGGAAAAA
GACTGGGACGAGCTGCGCGCGTTCGCGTCGAGCGAGCTCGGCCTCGCCGCGCTCGAGCCGTGGGACGTCGCGTATGCGGC
CGAGAAGCTGCGCGAGCGGCGCTACGCGTTCTCCGAGAACGAGGTGAAGCAGTATTTCCCCGAGCCGGCGGTGCTCAAGG
GGCTTTTCACGGTCGCCGAGACGCTGTTCGGCGTGCGGATCACGCGCGACGACGCGCCCGTCTGGCATGAGGACGTGCGC
TTCTTCCGCGTCGAGAACCGCGACGGCTCGCTCGTCGCGCAGTTCTATCTCGACCTGTACGCACGCGAAGGCAAGCGCGG
CGGCGCGTGGATGGACGACGCGCGCTCGCGCGCGAAGCGCGGCGACGGCCGCGTGCAGACGCCCGTCGCGTACCTGACCT
GCAACTTCTCCGCGCCGATCGGCGGCAAGCCCGCGTGCTTCACGCACGACGAAGTGATCACGCTGTTCCACGAGTTCGGC
CACGGGCTGCATCACATGCTCACGCGCGTCGACGAGATCGGCGTGTCCGGCATCAACGGCGTCGAATGGGACGCGGTCGA
GCTGCCGTCGCAGTTCATGGAGAACTTCTGCTGGGAGTGGGACGTGCTGAAGTCGATGTCGTCGCACGTCGACACGGGCG
ACGCGCTGCCGCGCGCGCTCTTCGACAAGATGCTCGCCGCGAAGAACTTCCAGAGCGGCCTCGGCACGCTGCGCCAGATC
GTGTTCTCGATGTTCGACATGCTGCTGCACGTCGATTTCGATCCGGCCGGCAAGACGAGCGTCAACGAGTTCGCGCGCGA
GATCAACGAGCGCTTCCATGTGATTGCGCAGGCGCCGTTCTCGCGCTGGCCGAACACGTTCAGCCACATCTTCGCGGGCG
GCTACGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTGCTGTCCGCCGACGCATACGCGGCGTTCGAGGAAGCGGCC
GGCTCGGCGGGCAGCGTGCTCGATGCGGCGACGGGCGCGCGCTATCGGCGCGAGATCCTCGAGGTCGGCGGCAGCCGCCC
GGCGATGGACTCGTTCAAGGCGTTCCGCGGCCGCGAGCCGAACATCGACGCGCTGCTGCGCCACAGCGGGATGGCCGACG
ACGCACAGGCGCGCGCGTAA

Upstream 100 bases:

>100_bases
AGCGCACGATGCGCCCCAATAATGTCGACATGACGAGACGGCCGCCGCCGTGCGCCGCCGTCTTCCGCCCAACCCGAAAC
CGAAACCGCCAGGGAGCACT

Downstream 100 bases:

>100_bases
TGCGCGCGGCGGCAAGCCTCGAGCGCGCCGCCTCGCCCGCCGGCTCCGCGCAACGACGAACGGCAACCCGCATCGGCGGG
TTGCCGTTTTTTCATCGCGC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNA
VADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDHKPRFAQL
QEQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEK
DWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRALFDKMLAAKNFQSGLGTLRQI
VFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAA
GSAGSVLDAATGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA

Sequences:

>Translated_699_residues
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNA
VADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDHKPRFAQL
QEQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEK
DWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRALFDKMLAAKNFQSGLGTLRQI
VFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAA
GSAGSVLDAATGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
>Mature_698_residues
SVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNAV
ADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDHKPRFAQLQ
EQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAMY
RAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEKD
WDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRF
FRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRALFDKMLAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAG
SAGSVLDAATGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=621, Percent_Identity=32.0450885668277, Blast_Score=309, Evalue=8e-84,
Organism=Homo sapiens, GI14149738, Length=620, Percent_Identity=31.7741935483871, Blast_Score=292, Evalue=7e-79,
Organism=Homo sapiens, GI156105687, Length=647, Percent_Identity=24.7295208655332, Blast_Score=169, Evalue=8e-42,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=49.4169096209913, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=695, Percent_Identity=30.9352517985612, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71999758, Length=486, Percent_Identity=26.1316872427983, Blast_Score=131, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=591, Percent_Identity=20.9813874788494, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=689, Percent_Identity=27.7213352685051, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6322715, Length=606, Percent_Identity=24.9174917491749, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356111, Length=704, Percent_Identity=26.4204545454545, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129717, Length=556, Percent_Identity=24.8201438848921, Blast_Score=159, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77900; Mature: 77769

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHH
IEQATEPLGRAWGVVGHLNAVADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SPEYAALSAERKKILDNALRDFRLSGAELPEDHKPRFAQLQEQQAALSKSFSDHVLDATN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCH
QQVIAFLEDLAKRARPFAEKDWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HHCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHH
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRAL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
FDKMLAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAGSAGSVLDAATGARYRREIL
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
HCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
SVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHH
IEQATEPLGRAWGVVGHLNAVADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SPEYAALSAERKKILDNALRDFRLSGAELPEDHKPRFAQLQEQQAALSKSFSDHVLDATN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCH
QQVIAFLEDLAKRARPFAEKDWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HHCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHH
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRAL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
FDKMLAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAGSAGSVLDAATGARYRREIL
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
HCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]