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The map label for this gene is lysS [H]

Identifier: 237813010

GI number: 237813010

Start: 2698533

End: 2700059

Strand: Direct

Name: lysS [H]

Synonym: GBP346_A2770

Alternate gene names: 237813010

Gene position: 2698533-2700059 (Clockwise)

Preceding gene: 237813009

Following gene: 237813011

Centisome position: 65.84

GC content: 65.88

Gene sequence:

>1527_bases
ATGACCGAACCGACCCAACCGCAGGCCGCTGTCGCAGCGGACGAAAACCAGATCGTCGCGGAGCGCCGCGACAAGCTGCG
CGCGCTGCGCGACCAAGGCATCGCCTATCCGAACGACTTCCAGCCGACGCACCACGCGGCCGGTCTGCAGACCGAATACG
CGGACGCCGACAAGGAAGCGCTCGACGCGAAGGCGCTCGACGTCGCGATCGCCGGCCGGATGATGCTCAAGCGCGTGATG
GGCAAGGCGAGCTTCGCGACGGTGCAGGACGGTTCGGGTCAAATCCAGTTCTTCGTGACGCCCGCCGATGTCGGCGCCGA
AACGTACGACGCGTTCAAGAAGTGGGACCTGGGCGACATCGTCGCCGCGCGCGGCGTGCTGTTTCGCACGAACAAGGGCG
AGCTGTCGGTGAAGTGCACGGAGCTGCGGCTGCTCGCGAAGGCGCTGCGTCCGCTGCCCGACAAGTTCCACGGCCTCGCC
GACCAGGAAACGCGCTATCGCCAGCGCTACGTCGATCTGATCGTCACGCCCGAGACGCGCGCGACGTTCCGCGCGCGCAC
GAAGGCGATCGCGTCGATCCGCAAGTTCATGAGCGACGCCGATTTCATGGAAGTCGAGACGCCGATGCTGCACCCGATCC
CGGGCGGCGCGGCCGCGAAGCCGTTCGTCACGCATCACAATGCGCTCGACATGCAAATGTTCCTGCGCATCGCGCCCGAG
CTTTACCTGAAGCGCCTGATCGTCGGCGGCTTCGAGCGCGTGTTCGAGATCAACCGCAACTTCCGGAACGAAGGCGTGTC
GCCGCGCCACAATCCGGAATTCACGATGATGGAGTTCTACGCCGCGTACACCGATTACCGCTGGCTGATGGACTTCACCG
AGCGGCTGATCCGCCAGGCGGCCGTCGACGCGCTCGGCACCGCGACGATCCGGTACCAGGGCCGCGAGCTCGATCTCGCC
AAGCCGTTCCATCGCCTGACGATCACGCAGGCGATCCAGAAATACGCACCGAACTACACGGACGGTCAGTTGTCGGACGA
CGCGTTCCTGCGCGGCGAACTCAAGCGCCTGGGCGTCGACGTCACGCAGCCGGCGTTCCTGAACGCCGGCATCGGCGCGC
TGCAGCTCGCGCTTTTCGAGGAAACCGCCGAAGCGCAGCTGTGGGAACCGACCTTCATCATCGACTACCCGATCGAGGTG
TCGCCGCTCGCGCGCGAATCGGACACGGTGGCGGGCATCACCGAGCGCTTCGAGCTGTTCGTCACCGGCCGTGAAATCGC
GAACGGCTTCTCGGAACTGAACGACCCCGAAGACCAGGCCGCGCGCTTCAGGAAGCAGGTCGAGCAGAAGGACGCGGGCG
ACGAAGAGGCGATGTTCTTCGACGCCGACTACATCCGCGCGCTCGAATACGGAATGCCGCCGACAGGCGGCTGCGGGATC
GGCATCGACCGGCTCGTGATGCTGCTGACCGACAGCCCGACGATTCGCGACGTGCTGCTGTTCCCGCACCTGCGCCGCGA
AGACTGA

Upstream 100 bases:

>100_bases
CGTGTAAGCGCCCCTTCGCGCGGGCGCGGCGCGAGCCGGCCCGCGCCGGTCGCGCGCGCACCGCGCCCCCGCTGCCGCAT
CACCCTCGAACCCGACCATC

Downstream 100 bases:

>100_bases
TTTCGCGCCACGCGGCCGCCGCGCCGCTCGTTCGCCGCGGCCGTCCGCCCCGCGCCCTCGCGCATTTTCGCCCGCTTTCG
CGGGCGGCGCGGGAAGGCGA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAIAGRMMLKRVM
GKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLA
DQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPE
LYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLA
KPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEV
SPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGI
GIDRLVMLLTDSPTIRDVLLFPHLRRED

Sequences:

>Translated_508_residues
MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAIAGRMMLKRVM
GKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLA
DQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPE
LYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLA
KPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEV
SPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGI
GIDRLVMLLTDSPTIRDVLLFPHLRRED
>Mature_507_residues
TEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAIAGRMMLKRVMG
KASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLAD
QETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPEL
YLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLAK
PFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVS
PLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIG
IDRLVMLLTDSPTIRDVLLFPHLRRED

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=509, Percent_Identity=39.4891944990177, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI194272210, Length=509, Percent_Identity=39.4891944990177, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI40789249, Length=325, Percent_Identity=21.8461538461538, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1789256, Length=506, Percent_Identity=57.7075098814229, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1790571, Length=506, Percent_Identity=57.1146245059289, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87082379, Length=326, Percent_Identity=31.9018404907975, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788173, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535925, Length=488, Percent_Identity=41.1885245901639, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17535927, Length=488, Percent_Identity=41.1885245901639, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI71994340, Length=488, Percent_Identity=41.1885245901639, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI32566633, Length=296, Percent_Identity=23.6486486486486, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=519, Percent_Identity=41.6184971098266, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324256, Length=549, Percent_Identity=30.7832422586521, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24640849, Length=528, Percent_Identity=39.2045454545455, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24640851, Length=523, Percent_Identity=39.5793499043977, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24584738, Length=353, Percent_Identity=25.2124645892351, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57217; Mature: 57086

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEA
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCCCHHH
LDAKALDVAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHCCCHHHHHHHCCCHHHH
VAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETR
HHHCCEEEECCCCCEEEEHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHEEEEECCCHH
ATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHH
LYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVD
HHHHHCCEEEEECCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
VTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELF
CCCCHHHHCCHHHHHHHHHHHHHHCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHEEEE
VTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGI
EECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCC
GIDRLVMLLTDSPTIRDVLLFPHLRRED
CHHHHEEEECCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEA
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCCCHHH
LDAKALDVAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHCCCHHHHHHHCCCHHHH
VAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETR
HHHCCEEEECCCCCEEEEHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHEEEEECCCHH
ATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHH
LYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVD
HHHHHCCEEEEECCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
VTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELF
CCCCHHHHCCHHHHHHHHHHHHHHCEECCCEEEEECCCCCCCCCCCCCHHHHHHHHEEEE
VTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGI
EECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCC
GIDRLVMLLTDSPTIRDVLLFPHLRRED
CHHHHEEEECCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA