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The map label for this gene is aceA [H]

Identifier: 237812840

GI number: 237812840

Start: 2531092

End: 2532660

Strand: Direct

Name: aceA [H]

Synonym: GBP346_A2594

Alternate gene names: 237812840

Gene position: 2531092-2532660 (Clockwise)

Preceding gene: 237812839

Following gene: 237812842

Centisome position: 61.76

GC content: 61.63

Gene sequence:

>1569_bases
ATGCTGCGTGGCACAACCCAGCCCATTGCAGCATGGAAAACCACATTCCGCAATAAGAAATATAGACGTCAATCTATTGA
TTTTAATGGAATAAATTTTTTACAGCTTCGTGAAAAAGCCCCCTGTCTCGACGCCGTCGATTTGCCTAGACTCTTATACA
AGACTTCACGAACGAAACCGCCGAACCCCAATCGCGCCGTCCGTTTCGCCCAGTCAAAGATTTCTTCTCTTCAGGCAACG
ACCACTCAAGGAGTACGCATCATGTCGCGTCAACAACAGGCTCAGGAACTGCAAAAGCAATGGGAAACCGATCCGCGCTG
GAAGGGCATCAAGCGCGCGTTCACCGCTGAGGACGTCGTGCGCCTGCGCGGCTCGATCCAGCAAGAGCACACGCTCGCGA
AGCGCGGCGCGGAAAAGCTCTGGACGCTCATCAACAACGAGCCGTTCGTCAACGCACTCGGCGCGCTGACGGGCAACCAG
GCGATGCAGCAGGTCAAGGCCGGCCTCAAGGCGATCTATCTGTCGGGCTGGCAAGTCGCGGGCGACGCGAACGTCGCGGG
CGAAATGTATCCGGACCAGTCGCTGTACCCGGCGAACTCGGTGCCGCTCGTCGTCAAGCGCATCAACAACACGCTCACGC
GCGCCGATCAGATCCAGTGGTCGGAAGGCAAGAACCCCGGCGACGAAGGCTATGTCGACTTCTTCGCGCCGATCGTCGCC
GACGCGGAAGCCGGCTTCGGCGGCGTGCTGAACGCGTTCGAACTGATGAAGGCGATGATCGAGGCGGGCGCGTCGGGCGT
TCACTTCGAAGATCAGCTCGCATCGGTCAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTCGTGCCGACCCGCGAGGCGG
TCGCGAAGCTGACGGCCGCGCGTCTCGCCGCCGACGTGATGGGCACGCCGACCGTGCTGGTCGCGCGCACCGACGCCGAA
GCGGCAGACCTGATCACGTCCGACATCGACGACAACGACAAGCCGTACCTGACGGGCGAGCGCACGGTCGAAGGCTTCTT
CCGCACGAAGCCGGGCCTCGAGCAGGCGATCTCGCGCGGCCTCGCCTATGCGCCGTACGCCGACCTGATCTGGTGCGAAA
CCGGCAAGCCGGATCTCGAATACGCGAAGAAGTTCGCGGAAGCGATCCACAAGCAGTTCCCGGGCAAGCTGCTGTCGTAC
AACTGCTCGCCGTCGTTCAACTGGAAGAAGAACCTCGACGACGCGACGATCGCGAAGTTCCAGAAGGAACTCGGCGCGAT
GGGCTACAAGTTCCAGTTCATCACGCTCGCCGGCTTCCATGCGCTGAACTACTCGATGTTCAACCTCGCGCACGGCTACG
CCCGCACGCAGATGAGCGCGTTCGTCGAACTGCAGCAAGCCGAGTTCGCGGCGGCCGACAAGGGCTTCACCGCGGTCAAG
CACCAGCGTGAAGTCGGCACCGGCTACTTCGACGCGGTGACTCAGACGGTCGAGCGCGAAGCGTCGACGACCGCGCTGCA
CGGCTCGACCGAAGACGAACAGTTCTTCGACGGCCAGAAAGTCGCCTGA

Upstream 100 bases:

>100_bases
GCGTACCCGCCCCGCCCCCGAAAACCGGCGCATTCGCGCCGGTTTTTGTTTGCGCCCGAGATTTCACGATACGAAAAAAA
CTTTTGCGTCGTAAAAAATC

Downstream 100 bases:

>100_bases
GCTCCGGCAGGCGCAGGCACGCCGCGCGCGGCCATGAGCCGCCGCGGCGCGCGACCCGGCAAGACCAAGACCATATCGGG
GAGCACTCGCCTGCGGCGCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MLRGTTQPIAAWKTTFRNKKYRRQSIDFNGINFLQLREKAPCLDAVDLPRLLYKTSRTKPPNPNRAVRFAQSKISSLQAT
TTQGVRIMSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQ
AMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVA
DAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAE
AADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSY
NCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVK
HQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Sequences:

>Translated_522_residues
MLRGTTQPIAAWKTTFRNKKYRRQSIDFNGINFLQLREKAPCLDAVDLPRLLYKTSRTKPPNPNRAVRFAQSKISSLQAT
TTQGVRIMSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQ
AMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVA
DAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAE
AADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSY
NCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVK
HQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA
>Mature_522_residues
MLRGTTQPIAAWKTTFRNKKYRRQSIDFNGINFLQLREKAPCLDAVDLPRLLYKTSRTKPPNPNRAVRFAQSKISSLQAT
TTQGVRIMSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQ
AMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVA
DAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAE
AADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSY
NCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVK
HQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=69.9769053117783, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=257, Percent_Identity=27.2373540856031, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17561814, Length=418, Percent_Identity=63.8755980861244, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71982926, Length=418, Percent_Identity=63.8755980861244, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=294, Percent_Identity=36.734693877551, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=256, Percent_Identity=33.203125, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 57749; Mature: 57749

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRGTTQPIAAWKTTFRNKKYRRQSIDFNGINFLQLREKAPCLDAVDLPRLLYKTSRTKP
CCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PNPNRAVRFAQSKISSLQATTTQGVRIMSRQQQAQELQKQWETDPRWKGIKRAFTAEDVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKAGLKAIYLSGWQVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEE
GDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHH
DAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
RLAADVMGTPTVLVARTDAEAADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRG
HHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCC
LAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFNWKKNLDDATIAKF
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHH
QKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVK
HHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA
HHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCC
>Mature Secondary Structure
MLRGTTQPIAAWKTTFRNKKYRRQSIDFNGINFLQLREKAPCLDAVDLPRLLYKTSRTKP
CCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PNPNRAVRFAQSKISSLQATTTQGVRIMSRQQQAQELQKQWETDPRWKGIKRAFTAEDVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKAGLKAIYLSGWQVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEE
GDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHH
DAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
RLAADVMGTPTVLVARTDAEAADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRG
HHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCC
LAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFNWKKNLDDATIAKF
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHH
QKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVK
HHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA
HHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]