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The map label for this gene is thiD_1 [H]

Identifier: 237812831

GI number: 237812831

Start: 2523681

End: 2524490

Strand: Direct

Name: thiD_1 [H]

Synonym: GBP346_A2585

Alternate gene names: 237812831

Gene position: 2523681-2524490 (Clockwise)

Preceding gene: 237812830

Following gene: 237812832

Centisome position: 61.57

GC content: 71.73

Gene sequence:

>810_bases
ATGACCCGACCGATTCCCAACGCGCTCACGATCGCCGGCTCCGATTCGGGCGGCGGCGCCGGCATCCAGGCCGACCTGAA
GACGTTCTCCGCGCTCGGCGCGTACGGCGCGAGCGTGATCACCGCGCTCACCGCGCAGAACACGCGCGGCGTGACGGGCG
TGCATGCGCCCGACGCAGGCTTCGTGAGCGCGCAGCTCGATGCGGTATTCGACGACATCCGCATCGACGCGGTGAAGATC
GGCATGCTCGCGAACGCGGCGATCGTGCGTGCGGTCGCGGCGGCGCTCACGCGTCACACGCCGCGCCACATCGTGCTCGA
CACGGTGATGATCTCGAAGAGCGCGCATGCGTTGCTCGCGCCCGACGCGGTCGACGCGCTGCGCAACGAATTGCTGCCGC
TCGCCGATCTCGTCACGCCGAATCTGCCCGAGGCGGCCGCGCTGCTCGGCGTCGCGGCCGCGACGACCGAGGACGACATG
GTGCGCCAGGGCGAGACGCTCGTCGCGCGCGGCGCGAAGGCGGTGCTGATGAAAGGCGGCCACCTCGGCGCCGAGCGCGA
AAGCCCGGACTGGCTGATTCATGCGGGCGGCGCGCAACGCTTCGCGGGCGCGCGGCTGCCGGTCGCGAACACGCACGGCA
CCGGGTGCACGCTGTCGTCGGCGATCGCCGCGCTGCTGCCGCAGCGGGCGACGCTCGCGGAGGCGATCGCCGATGCGAAG
ATCTACCTGACGGGCGCGATCGGCGCGAGCGGGCAGCTCGACGTCGGGCACGGCGTCGGGCCCGTGCATCACTTCTATCG
ATGGTGGTGA

Upstream 100 bases:

>100_bases
GCGCCGCCCATGCCGCGCCGCGTGCAGCCCATCGACCCGGCGACGCCGCGCGCCCTGCGCGTTTGCCCGTGAGCGCCGCA
ACCTGTCCCGCCTCGCCGCC

Downstream 100 bases:

>100_bases
GCCGGCGGTAGACGCCGGCTGCGAATCGACCGGCGCGGGCCGCCGCGCATGAAACGGATGGACGCCGCGAATCGACCGGA
ATCGACGCACCGGTCCGACG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAGFVSAQLDAVFDDIRIDAVKI
GMLANAAIVRAVAAALTRHTPRHIVLDTVMISKSAHALLAPDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDM
VRQGETLVARGAKAVLMKGGHLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAK
IYLTGAIGASGQLDVGHGVGPVHHFYRWW

Sequences:

>Translated_269_residues
MTRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAGFVSAQLDAVFDDIRIDAVKI
GMLANAAIVRAVAAALTRHTPRHIVLDTVMISKSAHALLAPDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDM
VRQGETLVARGAKAVLMKGGHLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAK
IYLTGAIGASGQLDVGHGVGPVHHFYRWW
>Mature_268_residues
TRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAGFVSAQLDAVFDDIRIDAVKIG
MLANAAIVRAVAAALTRHTPRHIVLDTVMISKSAHALLAPDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDMV
RQGETLVARGAKAVLMKGGHLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAKI
YLTGAIGASGQLDVGHGVGPVHHFYRWW

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=60.0760456273764, Blast_Score=314, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=32.9710144927536, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324997, Length=274, Percent_Identity=33.2116788321168, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324517, Length=274, Percent_Identity=32.4817518248175, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27515; Mature: 27384

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAG
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
FVSAQLDAVFDDIRIDAVKIGMLANAAIVRAVAAALTRHTPRHIVLDTVMISKSAHALLA
CHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCEEEC
PDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDMVRQGETLVARGAKAVLMKGG
CHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHHCCCEEEEEECC
HLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAK
CCCCCCCCCCEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCE
IYLTGAIGASGQLDVGHGVGPVHHFYRWW
EEEEEECCCCCCEECCCCCCHHHHHHHCC
>Mature Secondary Structure 
TRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAG
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCC
FVSAQLDAVFDDIRIDAVKIGMLANAAIVRAVAAALTRHTPRHIVLDTVMISKSAHALLA
CHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCEEEC
PDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDMVRQGETLVARGAKAVLMKGG
CHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHHCCCEEEEEECC
HLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAK
CCCCCCCCCCEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCE
IYLTGAIGASGQLDVGHGVGPVHHFYRWW
EEEEEECCCCCCEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]